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European Heart Journal 2001 22(22):2104-2115; doi:10.1053/euhj.2001.2622
Copyright © 2001 by the European Society of Cardiology.
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Availability of on-site catheterization and clinical outcomes in patients receiving fibrinolysis for ST-elevation myocardial infarction

J Llevadota,f1, R.P Giuglianoa,f1,f2, E.M Antmana, R.G Wilcoxb, E.P Gurfinkelc, T Henryd, C.H McCabea, A Charlesworthe, S Thompsone, J.C Nicolauf, U Tebbeg, Z Sadowskih and E Braunwald for the InTIME (intraenous nPA for Treatment of Infarcting Myocardium Early) II Invatigatorsa InTIME (intraenous nPA for Treatment of Infarcting Myocardium Early) II Invatigators

a TIMI Study Group, Cardiovascular Division, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, U.S.A.
b Division of Cardiovascular Medicine, Queen's Medical Centre, Nottingham, U.K.
c Fundacion Favaloro, Buenos Aires, Argentina
d Hennepin County Medical Center, Minneapolis, MN, U.S.A.
e Nottingham Clinical Research Group, Nottingham, U.K.
f Instituto de Coracao, Sao Paolo, Brasil
g Klinikum Lippe-Detmold, Detmold, Germany
h Klinika Choroby Wiencowej, Warsaw, Poland

revised January 23, 2001; accepted January 24, 2001

Abstract

Aims To compare management and clinical outcomes in hospitals stratified by the availability of on-site catheterization in InTIME-II, a multicentre trial comparing alteplase with lanoteplase for acute myocardial infarction.

Methods and Results We studied 15–078 patients enrolled in 35 countries and 855 hospitals. Thirty-one percent of hospitals had 24-h, 25% day-only, and 44% no on-site catheterization facilities. Rates of cardiac angiography (57%, 38%, 26%) and revascularization (37%, 21%, 17%) were higher in hospitals with increasing access to on-site facilities )

Conclusions There is a marked variation in procedure use by the availability of on-site catheterization with no major differences in patient outcomes. There is a need for additional randomized trials in the current era to address both the appropriate selection of patients and timing of invasive procedures in ST-elevation acute myocardial infarction.

Key Words: Myocardial infarction, fibrinolysis, availability of on-site catheterization, outcomes

f1 These authors contributed equally to the manuscript.

f2 Correspondence: Robert P. Giugliano MD, SM, TIMI Study Office, 333 Longwood Avenue, Suite 402, Boston, MA 02115, U.S.A.

References

  1. Fibrinolytic Therapy Trialists' (FTT) Collaborative Group, Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1000 patients, Lancet, 1994, 343, 311, 22, Lancet, 1994, 343, 742
  2. N Engl J Med. 1993;329:673–682[Abstract/Free Full Text]
  3. N Engl J Med. 1993;329:1615–1622[Abstract/Free Full Text]
  4. Ito H, Tomooka T, Sakai N. Lack of myocardial perfusion immediately after successful thrombolysis: a predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation. 1992;85:1699–1705[Abstract/Free Full Text]
  5. Llevadot J, Giugliano RP, McCabe CH. Degree of residual stenosis in the culprit coronary artery after thrombolytic administration (Thrombolysis In Myocardial Infarction (TIMI) Trials). Am J Cardiol. 2000;85:1409–1413[CrossRef][ISI][Medline]
  6. Meijer A, Verheught FW, Werter CJ. Aspirin versus coumadin in the prevention of reocclusion and recurrent ischemia after successful thrombolysis: a prospective placebo-controlled angiographic study: results of the APRICOT study. Circulation. 1993;87:1524–1530[Abstract/Free Full Text]
  7. Verheught FW, Meiger A, Lagrand WK, Van Eenige MJ. Reocclusion: the flip side of coronary thrombolysis. J Am Coll Cardiol. 1996;27:766–773[Abstract]
  8. Simoons ML, Arnold AER, Betriu A. Thrombolysis with tissue plasminogen activator in acute myocardial infarction: no additional benefit from immediate percutaneous coronary angioplasty. Lancet. 1988;1:197–203[Medline]
  9. N Engl J Med. 1989;320:618–627[Abstract]
  10. BMJ. 1991;302:555–560[ISI][Medline]
  11. Madsen JK, Grande P, Saunamdki K. Danish Multicenter Randomized Study of Invasive Versus Conservative Treatment in Patients With Inducible Ischemia After Thrombolysis in Acute Myocardial Infarction (DANAMI). Circulation. 1997;96:748–755[Abstract/Free Full Text]
  12. Hochman JS, Sleeper LA, Webb JG. Early revascularization in acute myocardial infarction complicated by cardiogenic shock. N Engl J Med. 1999;341:625–634[Abstract/Free Full Text]
  13. Ryan TJ, Antman EM, Brooks NH. 1999 update. ACC/AHA guidelines for the management of patients with acute myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). J Am Coll Cardiol. 1999;34:890–911[Free Full Text]
  14. Eur Heart J. 1996;17:43–63[Free Full Text]
  15. N Engl J Med. 1983;309:331–336[Abstract]
  16. Feit F, Mueller HS, Braunwald E. Thrombolysis in Myocardial Infarction (TIMI) phase II trial: outcome comparison of a conservative strategy in community versus tertiary hospitals. The TIMI Research Group. J Am Coll Cardiol. 1990;16:1529–1534[Abstract]
  17. Every NR, Larson EB, Litwin PE. The Myocardial Infarction Triage and Intervention Project Investigators. The association between on-site cardiac catheterization facilities and the use of coronary angiography after acute myocardial infarction. N Engl J Med. 1993;329:546–551[Abstract/Free Full Text]
  18. Spertus JA, Weiss NS, Every NR, Weaver WD. The influence of clinical risk factors on the use of angiography and revascularization after acute myocardial infarction. Arch Intern Med. 1995;155:2309–2316[Abstract]
  19. Pilote L, Miller DP, Califf RM, Rao JS, Weaver WD, Topol EJ. Determinants of the use of coronary angiography and revascularization after thrombolysis for acute myocardial infarction. N Engl J Med. 1996;335:1198–1205[Abstract/Free Full Text]
  20. Every NR, Parsons LS, Fihn SD. Long-term outcome in acute myocardial infarction patients admitted to hospitals with and without on-site cardiac catheterization facilities. Circulation. 1997;96:1770–1775[Abstract/Free Full Text]
  21. Marrugat J, Sanz G, Masia R. Six-month outcome in patients with myocardial infarction initially admitted to tertiary and nontertiary hospitals. RESCATE Investigators. Recursos Empleados en el Sindrome Coronario Agudo y Tiempos de Espera. J Am Coll Cardiol. 1997;30:1187–1192[Abstract]
  22. Krumholz HM, Chen J, Murillo JE, Cohen DH, Radford MJ. Admission to hospitals with on-site cardiac catheterization facilities: impact on long-term costs and outcomes. Circulation. 1998;98:2010–2016[Abstract/Free Full Text]
  23. Yusuf S, Flatcher M, Pogue J. Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. Lancet. 1998;352:507–514[CrossRef][ISI][Medline]
  24. Rogers WJ, Canto JG, Barron HV, Boscarino JA, Shoultz DA, Every NR. Treatment and outcome of myocardial infarction in hospitals with and without invasive capability. J Am Coll Cardiol. 2000;35:371–379[Abstract/Free Full Text]
  25. Eur Heart J. 2000;21:2005–2013[Abstract/Free Full Text]
  26. Giugliano RP, Llevadot J, Wilcox RG. Geographic variation in patient and hospital characteristics, management, and clinical outcomes in ST-elevation myocardial infarction treated with fibrinolysis. Eur Heart J. 2001;22:1702–1715[Abstract/Free Full Text]
  27. Morrow DA, Antman EM, Charlesworth A. TIMI risk score for ST-elevation myocardial infarction: a convenient, bedside, clinical score for risk assessment at presentation: an Intravenous nPA for Treatment of Infarcting Myocardium Early II Trial Substudy. Circulation. 2000;102:2031–2037[Abstract/Free Full Text]
  28. Rouleau JL, Moye LA, Pfeffer MA. A comparison of management patterns after acute myocardial infarction in Canada and the United States. N Engl J Med. 1993;328:779–874[Abstract/Free Full Text]
  29. Mark DB, Naylor CD, Hlatky MA. Use of medical resources and quality of life after acute myocardial infarction in Canada and the United States. N Engl J Med. 1994;331:1130–1135[Abstract/Free Full Text]
  30. Pilote L, Califf RM, Sapp S. Regional variation across the United States in the management of acute myocardial infarction. N Engl J Med. 1995;333:565–572[Abstract/Free Full Text]
  31. Guadagnoli E, Hauptman PJ, Ayanian JZ. Variation in the use of cardiac procedures after acute myocardial infarction. N Engl J Med. 1995;333:573–578[Abstract/Free Full Text]
  32. Selby JV, Fireman BH, Lundstrom RJ. Variation among hospitals in coronary-angiography practices and outcomes after myocardial infarction in a large health maintenance organization. N Engl J Med. 1996;335:1888–1896[Abstract/Free Full Text]
  33. Tu JV, Pashos CL, Naylor CD. Use of cardiac procedures and outcomes in elderly patients with myocardial infarction in the United States and Canada. N Engl J Med. 1997;336:1500–1505[Abstract/Free Full Text]
  34. Batchelor WB, Peterson ED, Mark DB. A comparison of US and Canadian cardiac catheterization practices in detecting severe coronary artery disease after myocardial infarction: efficiency, yield and long-term implications. J Am Coll Cardiol. 1999;34:12–19[Abstract/Free Full Text]
  35. Alderman EL, Bourassa MG, Cohen LS. Ten-year follow-up of survival and myocardial infarction in the randomized Coronary Artery Surgery Study. Circulation. 1990;82:1629–1646[Abstract/Free Full Text]
  36. Yusuf, S, Zucker, D, Peduzzi, P, Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomized trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration, Lancet, 1994, 334, 563, 70, Lancet, 1994, 344, 1446
  37. Ayanian JZ, Landrum MB, Normand S-LT. Rating the appropriateness of coronary angiography-do practicing physicians agree with an expert panel and with each other? N Engl J Med. 1998;338:1896–1904[Abstract/Free Full Text]
  38. Lee KL, Woodlief LH, Topol EJ. Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction. Results from an international trial of 41021 patients. Circulation. 1995;91:1659–1668[Abstract/Free Full Text]
  39. Hochman, JS, Boland, J, Sleeper, LA, Current spectrum of cardiogenic shock and effect of early revascularization on mortality: results of an international registry. Circulation, 1995, 91, 873, 81
  40. Berger PB, Holmes DR Jr, Stebbins AL, Bates ER, Califf RM, Topol EJ. Impact of an aggressive invasive catheterization and revascularization strategy on mortality in patients with cardiogenic shock in the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO-I) trial: an observational study. Circulation. 1997;96:122–127[Abstract/Free Full Text]

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