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European Heart Journal 2001 22(23):2135-2137; doi:10.1053/euhj.2001.2990
Copyright © 2001 by the European Society of Cardiology.
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Hotline Editorial

Should statin therapy be considered for patients with elevated C-reactive protein? The need for a definitive clinical trial

P.M. Ridker

Center for Cardiovascular Disease Prevention and the Leducq Centre for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, U.S.A.

References

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  2. Downs JR, Clearfield M, Weis S. Primary prevention of acute coronary events with lovastatin men and women with average cholesterol levels. Results of AFCAPS/TexCAPS. JAMA. 1998;279:1615–1622[Abstract/Free Full Text]
  3. Ridker PM. Evaluating novel cardiovascular risk factors: Can we better predict heart attacks? Ann Intern Med. 1999;130:933–937[Abstract/Free Full Text]
  4. Garber AM. Using cost-effectiveness analysis to target cholesterol reduction. Ann Intern Med. 2000;132:833–835[Free Full Text]
  5. Ridker PM, Cushman M, Stampfer MJ, Tracy R, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997;336:973–979[Abstract/Free Full Text]
  6. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836–843[Abstract/Free Full Text]
  7. Koenig W, Sund M, Froelich M. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring trends and determinants in cardiovascular disease) Augsberg Cohort Study, 1984 to 1992. Circulation. 1999;99:237–242[Abstract/Free Full Text]
  8. Danesh J, Whincup P, Wlaker M. Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ. 2000;321:199–204[Abstract/Free Full Text]
  9. Ridker PM, Stampfer MJ, Rifai N. Novel risk factors for systemic atherosclerosis. A comparison of C-reactive protein, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA. 2001;285:2481–2485[Abstract/Free Full Text]
  10. Ridker PM, Rifai N, Pfeffer M, Sacks F, Braunwald E. Long-term effects of Pravastatin on plasma concentration of C-reactive protein. Circulation. 1999;100:230–235[Abstract/Free Full Text]
  11. Albert MA, Danielson E, Rifai N, Ridker PM. Effect of statin therapy on C-reactive protein levels. The Pravastatin Inflammation/CRP Evaluation (PRINCE): A randomized trial and cohort study. JAMA. 2001;286:64–70[Abstract/Free Full Text]
  12. Ridker PM, Rifai N, Clearfield M, Downs JR, Weis SE, Miles JS, Gotto AM Jr. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med. 2001;344:1959–1965[Abstract/Free Full Text]
  13. Gotto AM Jr, Whitney E, Stein EA. Relation between baseline and on-treatment lipid parameters and first acute major coronary events in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). Circulation. 2000;101:477–484[Abstract/Free Full Text]
  14. Ridker PM, Rifai N, Lowenthal SP. Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia. Circulation. 2001;103:1191–1193[Abstract/Free Full Text]
  15. Ridker PM, Rifai N, Pfeffer MA. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Circulation. 1998;98:839–844[Abstract/Free Full Text]
  16. Horne BD, Muhlestein JB, Carlquist JF. Statin therapy, lipid levels, C-reactive protein and the survival of patients with angiographically severe coronary artery disease. J Am Coll Cardiol. 2000;36:1774–1780[Abstract/Free Full Text]

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