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European Heart Journal 2001 22(23):2140-2141; doi:10.1053/euhj.2001.2951
Copyright © 2001 by the European Society of Cardiology.
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Editorials

Diagnosing myocardial iron overload

A.V. Hoffbrand

Royal Free Hospital, London, U.K.

References

  1. Hussain MAM, Flynn DM, Green N, Hussein S, Hoffbrand AV. Subcutaneous infusion and intramuscular injection of desferrioxamine in patients with transfusional iron overload. Lancet. 1976;2:1278–1280[Medline]
  2. Propper RL, Cooper B, Rufo RR. Continuous subcutaneous administration of deferoxamine in patients with iron overload. N Engl J Med. 1977;297:418–423[Abstract]
  3. Zurlo MF, DeStefano P, Borgna Pignatti C. Survival and causes of death in thalassaemia major. Lancet. 1989;2:27–30[ISI][Medline]
  4. Gabutti V, Piga A. Results of long-term iron chelating therapy. Acta Haematologica. 1996;95:26–36[ISI][Medline]
  5. Wolfe L, Olivieri N, Sallam D. Prevention of disease by subcutaneous deferoxamine in patients with thalassemia major. N Engl J Med. 1985;312:166–1603
  6. Aldouri MA, Hoffbrand AV, Flynn DM. High incidence of cardiomyopathy in beta thalassaemia patients receiving transfusion and iron chelation: reversal by intensified chelation. Acta Haemato. 1990;84:113–117
  7. Link G, Saada A, Pinson A, Konijn AM, Hershko C. Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells. J Lab Clin Med. 1998;131:466–474[CrossRef][Medline]
  8. Al-Refaie FN, Wickens DG, Wonke B, Kontoghiorghes GJ, Hoffbrand AV. Serum iron-transferrin-bound iron in beta-thalassaemia major patients treated with desferrioxamine and L1. Br J Haemat. 1992;82:431–436[ISI][Medline]
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  11. Anderson L, Holden S, Davis B. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001;22:2171–2179[Abstract/Free Full Text]
  12. Marcus RE, Davies SC, Bartock HM, Underwood SR, Walton S, Huehns ER. Desferrioxamine to improve cardiac function in iron-overloaded patients with thalassaemia major. Lancet. 1984;1:392[Medline]
  13. Porter JB. A risk benefit assessment of iron-chelation therapy. Drugs Safety. 1997;17:407–421
  14. Barman Balfour KA, Foster RH. Deferiprone: A review of its clinical potential in iron overload in ß-thalassaemia major and other transfusion-dependent diseases. Drugs. 1999;3:553–578
  15. Wonke B, Wright C, Hoffbrand AV. Combined therapy with deferiprone and desferrioxamine. Br J Haemat. 1998;103:361–364[CrossRef][Medline]
  16. Breuer W, Erners MJJ, Pootrakul P, Abramov A, Hershko C, Cabantenik ZI. Desferrioxamine-chelatable iron a component of serum non-transferrin-bound iron, used for assessing chelation therapy. Blood. 2001;97:792–798[Abstract/Free Full Text]

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