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European Heart Journal 2001 22(4):300-306; doi:10.1053/euhj.2000.2281
Copyright © 2001 by the European Society of Cardiology.
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Prognostic value of exercise testing in a cohort of patients followed for 15 years after acute myocardial infarction

H Domínguezf1, C Torp-Pedersen, L Koeber and C Rask-Madsen

Department of Cardiology P, Gentofte University Hospital, Denmark

revised May 22, 2000; accepted May 24, 2000

Abstract

Aims To study the long-term prognostic information obtained from an exercise test following an acute myocardial infarction.

Methods Between 1979 and 1983, 1773 consecutive patients were admitted to Glostrup County Hospital with an acute myocardial infarction. Of 1430 patients who were alive after 3 weeks, 718 performed an exercise test. Survival data were available after 15 years for all patients.

Results Participation in an exercise test was associated with a risk reduction of death of 56% (95% confidence interval, 49–65%) when adjusting for known differences between the groups. Among patients who performed the test, most indicators of ischaemia were without prognostic information. Exercise tolerance, expressed in metabolic equivalents, was the best predictor of future mortality (relative risk 0·86 for an increase of one metabolic equivalent (0·80–0·92)). Only ST-segment depression of 2mm or more could identify a population with an increased risk of death (relative risk 1·45 (1·08–1·95)).

Conclusion Patients who perform an exercise test after acute myocardial infarction are a low risk population compared to those who do not perform it. The detection of ischaemia during the test is of marginal prognostic value. Exercise capacity is the most powerful predictor of death that can be obtained from the test.

Key Words: Exercise test, myocardial infarction, prognosis

f1 Correspondence: H. Dominguez. Mikkelborg Allé 11, DK-2970 Hoersholm, Denmark

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