Copyright © 2001 by the European Society of Cardiology.
Hotline Editorials
Homocysteine an innocent bystander in vascular disease?
National Heart and Lung Institute, Imperial College School of Medicine, London, U.K.
References
- Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338:10421050
[Free Full Text] - McCully KS. Vascular pathology of homocyst(e)inemia: implications for the development of arteriosclerosis. Am J Pathol. 1969;56:111128[ISI][Medline]
- Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995;274:10491057[Abstract]
- Danesh J, Lewington S. Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies. J Cardiovasc Risk. 1998;5:229232[Medline]
- Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;337:230236
[Abstract/Free Full Text] - Alfthan G, Aro A, Gey KF. Plasma homocysteine and cardiovascular disease mortality. Lancet. 1997;349:97
- Chambers JC, Obeid OA, Refsum H. Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men. Lancet. 2000;355:523527[CrossRef][ISI][Medline]
- Chambers JC, Ireland H, Thompson E. The methylenetetrahydrofolate reductase 677 C
T mutation, and coronary heart disease risk in UK Indian Asians. Arterioscler Thromb Vasc Biol. 2000;:
- Dudman NP. An alternative view of homocysteine. Lancet. 1999;354:20722074[CrossRef][ISI][Medline]
- Chambers JC, McGregor A, Jean Marie J, Kooner JS. Acute hyperhomocysteinaemia and endothelial dysfunction. Lancet. 1997;351:3637
- Chambers JC, McGregor A, Jean Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation. 1999;99:11561160
[Abstract/Free Full Text] - Chambers JC, Obeid OA, Kooner JS. Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects. Arterioscler Thromb Vasc Biol. 1999;19:29222927
[Abstract/Free Full Text] - Bellamy MF, McDowell IF, Ramsey MW. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation. 1998;98:18481852
[Abstract/Free Full Text] - Kanani PM, Sinkey CA, Browning RL, Allaman M, Knapp HR, Haynes WG. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocysteinaemia in humans. Circulation. 1999;100:11611168
[Abstract/Free Full Text] - Stamler JS, Osborne JA, Jaraki O. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993;91:308318[ISI][Medline]
- Blundell G, Jones BG, Rose FA, Tudball N. Homocysteine mediated endothelial cell toxicity and its amelioration. Atherosclerosis. 1996;122:163172[CrossRef][ISI][Medline]
- Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest. 1996;98:57[ISI][Medline]
- Ventura P, Panini R, Verlato C, Scarpetta G, Salvioli G. Peroxidation indices and total antioxidant capacity in plasma during hyperhomocysteinemia induced by methionine oral loading. Metabolism. 2000;49:225228[CrossRef][ISI][Medline]
- Voutilainen S, Morrow JD, Roberts LJ. Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels. Arterioscler Thromb Vasc Biol. 1999;19:12631266
[Abstract/Free Full Text] - Clarke R, Collins R. Can dietary supplements with folic acid or vitamin B6 reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease. J Cardiovasc Risk. 1998;5:249255[Medline]
- Bellamy MF, McDowell IF, Ramsey MW, Brownlee M, Newcombe RG, Lewis MJ. Oral folate enhances endothelial function in hyperhomocysteinaemic subjects. Eur J Clin Invest. 1999;29:659662[CrossRef][ISI][Medline]
- Woo KS, Chook P, Lolin YI, Sanderson JE, Metreweli C, Celermajer DS. Folic acid improves arterial endothelial function in adults with hyperhomocystinemia. J Am Coll Cardiol. 1999;34:20022006
[Abstract/Free Full Text] - Chambers JC, Ueland PM, Obeid OA, Wrigley J, Refsum H, Kooner JS. Improved vascular endothelial function after oral B vitamins; an effect mediated through reduced concentrations of free plasma homocysteine. Circulation. 2000;:
- van den BM, Boers GH, Franken DG. Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease. Eur J Clin Invest. 1995;25:176181[ISI][Medline]
- Vermeulen EG, Stehouwer CD, Twisk JW. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet. 2000;355:517522[CrossRef][ISI][Medline]
- Bostom AG, Garber C. Endpoints for homocysteine-lowering trials. Lancet. 2000;355:511512[CrossRef][ISI][Medline]
This article has been cited by other articles:
![]() |
C-K Wong, C J K Hammett, R The, J K French, W Gao, B J Webber, J M Elliott, A W Hamer, J A Ormiston, M W I Webster, et al. Lack of association between baseline plasma homocysteine concentrations and restenosis rates after a first elective percutaneous coronary intervention without stenting Heart, November 1, 2004; 90(11): 1299 - 1302. [Abstract] [Full Text] [PDF] |
||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
