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European Heart Journal 2002 23(10):788-793; doi:10.1053/euhj.2001.2970
Copyright © 2002 by the European Society of Cardiology.
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Urate predicts subsequent cardiac death in stroke survivors

K.Y.K. Wonga,f1, R.S. Macwalterb, H.W. Fraserb, I. Crombiec, S.A. Ogstonc and A.D. Struthersa

a The Cardiovascular Research Group, Department of Clinical Pharmacology & Therapeutics, University of Dundee Medical School, Ninewells Hospital, Dundee, U.K.
b Stroke Studies Centre, Department of Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, U.K.
c Epidemiology & Public Health, University of Dundee Medical School, Ninewells Hospital, Dundee, U.K.

revised August 7, 2001; accepted August 15, 2001

Abstract

Aims To test the hypothesis that urate predicts cardiac death after stroke independent of conventional risk factors of atherosclerosis, creatinine and diuretic use.

Methods and Results Serum urate concentration was measured in an unselected cohort of 354 stroke survivors who were followed-up for a median of 2·8 years. Cardiac death was the primary end-point. Urate was associated with a statistically significant threefold increase in relative risk of cardiac death even after adjustment for other conventional risk factors. In the subgroup of patients who were not on diuretics, raised urate was associated with a 12-fold significant increase in relative risk of cardiac death after adjusting for renal function and other conventional risk factors. A urate concentration of greater than 0·31mmol.l–1 was 78% sensitive at predicting cardiac death within 5 years after stroke, but was only 54% specific. If urate exceeded 0·38mmol.l–1, specificity of predicting cardiac death within 5 years after stroke was 88%.

Conclusions Elevated serum urate concentration may be used to stratify risk of future cardiac death after stroke. This appeared to be true even in stroke survivors who were not on diuretic therapy.

Key Words: Urate, stroke, cardiac death

f1 Correspondence: Dr Kenneth Wong, The Cardiovascular Research Group, Department of Clinical Pharmacology & Therapeutics, Ninewells Hospital, Dundee DD1 9SY, U.K.

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