Skip Navigation

European Heart Journal 2002 23(13):1021-1029; doi:10.1053/euhj.2001.2974
Copyright © 2002 by the European Society of Cardiology.
This Article
Right arrow Abstract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ferreirós, E.R.
Right arrow Articles by Krauss, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferreirós, E.R.
Right arrow Articles by Krauss, J.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

First national survey on management strategies in non ST-elevation acute ischaemic syndromes in Argentina. Results of the STRATEG–SIA study

E.R. Ferreirósf1, R. Kevorkian, J.J. Fuselli, J. Guetta, C.P. Boissonnet, D. di Toro, R. Cragnolino, O. Masoli, A. Cagide and J. Krauss

Area de Investigación, Sociedad Argentina de Cardiología, Buenos Aires, Argentina

revised August 20, 2001; accepted August 22, 2001

Abstract

Aims To assess the management strategies applied in non-ST elevation acute ischaemic syndromes in Argentina, the factors influencing the choice of treatment, and their relationship to short- and long-term (1 year) patient outcomes.

Methods and Results We conducted a 1 month, prospective, population-based survey in 77 hospitals (all over the country). We recruited 492 patients (age 63·9±11·7 years, male sex 68·3%, and 59·8% acute ischaemic ECG changes). Subjects were stratified according to the AHCPR classification as: high risk 62·2%, intermediate 25·0% and low 12·8%. At 1 year, the rate of death or myocardial infarction according to risk category and invasive procedures employed were: high risk (angioplasty 5·4% vs coronary artery bypass grafting 12·1% vs medical treatment 17·2%;P =0·001), intermediate risk (angioplasty 5·7% vs coronary artery bypass grafting 12·5% vs medical treatment 4·7%, P=ns), and low risk (angioplasty 10·0% vs coronary artery bypass grafting 15·2% vs medical treatment 1·9%; P<0·001). In the overall population, the 1 year event rate was not significantly different between the invasive and medical treatment groups (11·5% vs 7·2%, P=0·09).

Conclusions A routine, unselected invasive approach in non-ST elevation acute ischaemic syndromes in Argentina is associated with no apparent improvement of patients' outcome. Copyright 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.

Key Words: Unstable angina, myocardial infarction, management strategies

f1 Correspondence: Ernesto R. Ferreirós, Area de Investigación, Sociedad Argentina de Cardiología. Azcuénaga 980, Ciudad de Buenos Aires, Argentina.

References

  1. Rev Argent Cardiol. 1991;59:7–40
  2. Rev Argent Cardiol. 1998;66:63–72
  3. Théroux P, Fuster V. Acute coronary syndromes. Unstable angina and non-Q-wave myocardial infarction. Circulation. 1998;97:1195–1206[Free Full Text]
  4. Circulation. 1994;89:1545–1556[Abstract/Free Full Text]
  5. Anderson VH, Cannon CP, Stone PH. One-year results of the Thrombolysis in Myocardial Infarction (TIMI) IIIB clinical trial. A randomized comparison of tissue-type plasminogen activator versus placebo and early invasive versus early conservative strategies in unstable angina and non-Q-wave myocardial infarction. J Am Coll Cardiol. 1995;26:1643–1650[Abstract]
  6. Boden WE, O'Rourke RA, Crawford MH. Outcomes in patients with acute non-Q-wave myocardial infarction randomly assigned to an invasive as compared with a conservative management strategy for the Veterans Affairs Non-QWave Infarction Strategies in Hospital (VANQWISH) trial investigators. N Engl J Med. 1998;338:1785–1792[Abstract/Free Full Text]
  7. Lancet. 1999;354:708–715[CrossRef][Web of Science][Medline]
  8. Wallentin L, Lagerqvist B, Husted S, Knotny F, Stahle E, Swahn E. Outcome at 1 year after an invasive compared with a non-invasive strategy in unstable coronary-artery disease: the FRISC II invasive randomised trial. Lancet. 2000;356:9–16[CrossRef][Web of Science][Medline]
  9. Yusuf S, Flather M, Pogue J. Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. Lancet. 1998;352:507–514[CrossRef][Web of Science][Medline]
  10. Maggioni AP, Schweiger C, Tavazzi L. Epidemiologic study of use of resources in patients with unstable angina: the EARISA registry. Am Heart J. 2000;140:253–263[CrossRef][Web of Science][Medline]
  11. Collinson J, Flather MD, Fox KAA. Clinical outcomes, risk stratification and practice patterns of unstable angina and myocardial infarction without ST elevation: Prospective Registry of Acute Ischaemic Syndromes in the UK (PRAIS-UK). Eur Heart J. 2000;21:1450–1457[Abstract/Free Full Text]
  12. Scull GS, Martin JS, Weaver DW, Every NR. Early angiography versus conservative treatment in patients with non-ST elevation acute myocardial infarction. J Am Coll Cardiol. 2000;35:895–902[Abstract/Free Full Text]
  13. Lupón J, Valle V, Marrugat J. Six-month outcome in unstable angina patients without previous myocardial infarction according to the use of tertiary cardiologic resources. J Am Coll Cardiol. 1999;34:1947–1953[Abstract/Free Full Text]
  14. Mathew V, Farkouh ME, Reeder GS. Early angiography in the evaluation of patients presenting with unstable angina (Abstr). Circulation. 1999;100:532-I
  15. Fu Y, Chang W-C, Mark D. Canadian-American differences in the management of acute coronary syndromes in the GUSTO IIb Trial. One year follow up of patients without ST-segment elevation. Circulation. 2000;102:1375–1381[Abstract/Free Full Text]
  16. Braunwald E, Jones R, Mark DB. Diagnosing and managing unstable angina. Circulation. 1994;90:613–622[Abstract/Free Full Text]
  17. Braunwald E, Antman EM, Beasley JW. ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina). J Am Coll Cardiol. 2000;36:970–1062[Free Full Text]
  18. Bertrand ME, Simoons ML, Fox KAA. Management of acute coronary syndromes: acute coronary syndromes without persistent ST-segment elevation. Recommendations of the Task Force of the European Society of Cardiology. Eur Heart J. 2000;21:1406–1432[Free Full Text]
  19. Pilote L, Miller DP, Califf R. Determinants of the use of coronary angiography and revascularization after thrombolysis for acute myocardial infarction. N Engl J Med. 1996;335:1198–1205[Abstract/Free Full Text]
  20. Stone PH, Thompson B, Anderson V. Influence of race, sex, and age on management of unstable angina and non-Q-wave myocardial infarction. The TIMI III Registry. JAMA. 1996;275:1104–1112[Abstract/Free Full Text]
  21. Calvin JE, Klein LW, Van den Berg BJ, Meyer P, Ramirez-Morgen LM, Parrillo JE. Clinical predictors easily obtained at presentation predict resource utilization in unstable angina. Am Heart J. 1998;136:373–381[CrossRef][Web of Science][Medline]
  22. Van Miltenburg AJM, Simoons ML, Bossuyt PMM, Taylor TR, Veerhoek MJ. Variation in the use of coronary angiography in patients with unstable angina is related to differences in patient population and availability of angiography facilities, without affecting prognosis. Eur Heart J. 1996;17:1828–1835[Abstract/Free Full Text]
  23. Hasdai D, Holmes DR, Criger DA. Age and outcome after acute coronary syndromes without persistent ST-segment elevation. Am Heart J. 2000;139:858–866[Web of Science][Medline]
  24. Yusuf S, Zucker D, Peduzzi P. Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomised trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration. Lancet. 1994;344:563–570[CrossRef][Web of Science][Medline]
  25. Cannon CP, McCabe CH, Stone PH. The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q-wave myocardial infarction: Results of the TIMI III Registry ECG Ancillary Study. J Am Coll Cardiol. 1997;30:132–140
  26. Lindahl B, Venge P, Wallentin L. Relation between Troponin T and the risk of subsequent cardiac events in Unstable Coronary Artery Disease. Circulation. 1996;93:1651–1657[Abstract/Free Full Text]
  27. Ohman ME, Armstrong PW, Christenson RH. For the GUSTO IIA investigators. Cardiac Troponin T levels for risk stratification in acute myocardial ischemia. N Engl J Med. 1996;335:1333–1341[Abstract/Free Full Text]
  28. Antman EM, Tanasijevic MJ, Thompson B. Cardiac specific Troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med. 1996;335:1342–1349[Abstract/Free Full Text]
  29. Liuzzo G, Biasucci LM, Gallimore JR. The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med. 1994;331:417–424[Abstract/Free Full Text]
  30. Ferreirós ER, Boissonnet CP, Pizarro R. Independent prognostic value of elevated C-reactive protein in unstable angina. Circulation. 1999;100:1958–1963[Abstract/Free Full Text]
  31. Heeschen C, Hamm CW, Bruemmer J, Simoons ML. Predictive value of C-reactive protein and Troponin T in patients with unstable angina: a comparative analysis. J Am Coll Cardiol. 2000;35:1535–1542[Abstract/Free Full Text]
  32. Lindahl B, Toss H, Siegbahn A, Venge P, Wallentin L. Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. N Engl J Med. 2000;343:1139–1147[Abstract/Free Full Text]
  33. Wilcox I, Freedman SB, Allman KC. Prognostic significance of a predischarge exercise test in risk stratification after unstable angina pectoris. J Am Coll Cardiol. 1991;18:677–683[Abstract]
  34. Lindahl B, Andrén B, Ohlsson J. Risk stratification in unstable coronary artery disease: additive value of troponin T determinations and predischarge exercise tests. Eur Heart J. 1997;18:762–770[Abstract/Free Full Text]
  35. Madsen JK, Grande P, Saunakami K. Danish multicenter randomized study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction. Circulation. 1996;96:748–755
  36. Giugliano RP, Lloyd-Jones DM, Camargo CA Jr, Makary MA, O'Donnell CJ. Association of unstable angina guideline care with improved survival. Arch Intern Med. 2000;160:1775–1780[Abstract/Free Full Text]
  37. Antman EM, Cohen M, Bernink PJ. The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA. 2000;284:835–842[Abstract/Free Full Text]
  38. Cannon CP, Weintraub WS, Demopoulos LA. Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIbIIIa inhibitor Tirofiban. N Engl J Med. 2001;344:1879–1887[Abstract/Free Full Text]
  39. Alpert JS. Are data from clinical registries of any value? Eur Heart J. 2000;21:1399–1401[Free Full Text]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
Eur Heart JHome page
A. Di Chiara, F. Chiarella, S. Savonitto, D. Lucci, L. Bolognese, S. De Servi, C. Greco, A. Boccanelli, P. Zonzin, S. Coccolini, et al.
Epidemiology of acute myocardial infarction in the Italian CCU network: The BLITZ Study
Eur. Heart J., September 2, 2003; 24(18): 1616 - 1629.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
D.P. de Arenaza, A. Bakhai, and M. Flather
Coronary angiography and revascularization for acute coronary syndromes without ST elevation: the next challenge
Eur. Heart J., July 1, 2002; 23(13): 997 - 999.
[Full Text] [PDF]


This Article
Right arrow Abstract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ferreirós, E.R.
Right arrow Articles by Krauss, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferreirós, E.R.
Right arrow Articles by Krauss, J.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?