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European Heart Journal 2002 23(14):1071-1074; doi:10.1053/euhj.2001.3150
Copyright © 2002 by the European Society of Cardiology.
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Editorials

The Gly389Arg beta-1 adrenoceptor polymorphism and cardiovascular disease: time for a rethink in the funding of genetic studies?

A. Jones and H. Montgomery

UCL Centre for Cardiovascular Genetics, Rayne Institute, London, U.K.

References

  1. White HL. An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals at risk of coronary events. A WOSCOPS substudy. Eur Heart J. 2002;23:1087–1092[Abstract/Free Full Text]
  2. Brull DJ, Montgomery HE, Sanders J. Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol. 2001;21:1458–1463[Abstract/Free Full Text]
  3. Mason DA, Moore JD, Green SA, Liggett SB. A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J Biol Chem. 1999;274:12670–12674[Abstract/Free Full Text]
  4. Xie HG, Dishy V, Sofowora G. Arg389Gly beta1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo. Pharmacogenetics. 2001;11:191–197[CrossRef][ISI][Medline]
  5. Buscher R, Belger H, Eilmes KJ. In-vivo studies do not support a major functional role for the Gly389Arg beta1-adrenoceptor polymorphism in humans. Pharmacogenetics. 2001;11:199–205[CrossRef][ISI][Medline]
  6. O'Shaughnessy KM, Fu B, Dickerson C, Thurston D, Brown MJ. The gain-of-function G389R variant of the beta 1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjects. Clin Sci (Colch). 2000;99:233–238[Medline]
  7. Bengtsson K, Melander O, Orho-Melander M. Polymorphism in the beta(1)-adrenergic receptor gene and hypertension. Circulation. 2001;104:187–190[Abstract/Free Full Text]
  8. Ohtsuka T, Hamada M, Hiasa G. Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy. J Am Coll Cardiol. 2001;37:412–417[Abstract/Free Full Text]
  9. Brull DJ, Sanders J, Rumley A. Statin therapy and the acute inflammatory response after coronary artery bypass grafting. Am J Cardiol. 2001;88:431–433[CrossRef][ISI][Medline]
  10. Liuzzo G, Rizzello V. C-reactive protein and primary prevention of ischemic heart disease. Clin Chim Acta. 2001;311:45–48[CrossRef][ISI][Medline]
  11. Bristow MR, Ginsburg R, Umans V. B1 and B2 adrenergic receptor subpopulations in nonfailing and failing human ventricular myocardium: Coupling of both receptor subtypes to muscle contraction and selective B1 receptor down-regulation in heart failure. Circ Res. 1986;59:297–309[Abstract/Free Full Text]
  12. Hall JA, Petch MC, Brown MJ. In vivo demonstration of cardiac beta 2 adrenoreceptor sensitization by beta1 antagonist treatment. Circ Res. 1991;69:959–964[Abstract/Free Full Text]
  13. von Kanel R, Dimsdale JE. Effects of sympathetic activation by adrenergic infusions on haemostasis in vivo. Eur J Haematol. 2000;65:357–369[CrossRef][ISI][Medline]

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