Skip Navigation

European Heart Journal 2002 23(14):1083-1086; doi:10.1053/euhj.2001.2980
Copyright © 2002 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Montgomery, H.
Right arrow Articles by Danilov, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Montgomery, H.
Right arrow Articles by Danilov, S.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Reviews

Is genotype or phenotype the better tool for investigating the role of ACE in human cardiovascular disease?

H. Montgomerya,f1, S. Humphriesa and S. Danilovb

a UCL Centre for Cardiovascular Genetics, Rayne Institute, London, U.K.
b Department of Anaesthesiology, University of Illinois at Chicago, Chicago, U.S.A.

revised August 9, 2001; accepted August 15, 2001

Key Words: ACE genotype, phenotype

f1 Correspondence: Dr Montgomery, UCL Centre for Cardiovascular Genetics, 3rd Floor, Rayne Institute, 5 University Street, London WC1E 6JJ, U.K.

References

  1. Fonarow GC, Chelimsky-Fallick C, Stevenson LW. Effect of direct vasodilation with hydralazine versus angiotensin-converting enzyme inhibition with captopril on mortality in advanced heart failure: the Hy-C trial. J Am Coll Cardiol. 1992;19:842–850[Abstract]
  2. Bunneman B, Fuxe K, Ganten D. The brain renin-angiotensin system: Localization and general significance. J Cardiovasc Pharmacol. 1992;19:S51–S62
  3. Schaufelberger M, Drexler H, Schieffer E, Swedberg K. Angiotensin-converting enzyme gene expression in skeletal muscle in patients with chronic heart failure. J Card Fail. 1998;4:185–191[CrossRef][Medline]
  4. Swales JD, Samani NJ. Vascular RAA system. J Human Hypertension. 1993;7:S3–S6[Medline]
  5. Hagemann A, Nielsen AH, Poulsen K. The uteroplacental renin-angiotensin system: a review. Exp Clin Endocrinol. 1994;102:252–261[ISI][Medline]
  6. Harris RC, Cheng HF. The intrarenal renin-angiotensin system: a paracrine system for the local control of renal function separate from the systemic axis. Exp Nephrol. 1996;4:2–7[Medline]
  7. Metzger R, Bohle RM, Pauls K, Eicher G, Alhenc-Gelas F, Danilov SM. Angiotensin-converting enzyme in non-neoplastic kidney diseases. Kidney Int. 1999;56:1442–1452[CrossRef][ISI][Medline]
  8. Cambien F, Alhenc-Gelas F, Herbeth B. Familial resemblance of plasma angiotensin-converting enzyme level: Tha Nancy study. Am J Hum Genet. 1988;43:774–780[ISI][Medline]
  9. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86:1343–1346[ISI][Medline]
  10. Jan Danser AH, Maarten ADH, Schalekamp MADH. Angiotensin-converting enzyme in the human heart: effect of the deletion/insertion polymorphism. Circulation. 1995;92:1387–1388[Abstract/Free Full Text]
  11. Costerousse O, Allegrini J, Lopez M, Alhenc-Gelas F. Angiotensin 1-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochem J. 1993;290:33–40[ISI][Medline]
  12. Wang J-G, Staessen JA. Genetic polymorphisms in the renin-angiotensin system: relevance for susceptibility to cardiovascular disease. Eur J Pharmacol. 2000;410:289–302[CrossRef][ISI][Medline]
  13. Jan Danser AH, Schunkert H. Renin-angiotensin system gene polymorphisms: potential mechanisms for their association with cardiovascular diseases. Eur J Pharmacol. 2000;410:303–316[CrossRef][ISI][Medline]
  14. Staessen JA, Wang JG, Ginocchio G. The deletion/insertion polymorphism of the converting-enzyme and cardiovascular-renal risk. J Hypertens. 1997;15:1579–1592[CrossRef][ISI][Medline]
  15. Keavney B, McKenzie C, Parish S. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet. 2000;35:434–442
  16. Samani NJ, Thompson JR, O'Toole L, Channer K, Woods KL. A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction. Circulation. 1996;94:708–712[Abstract/Free Full Text]
  17. Pinto YM, van Gilst WH. The ACE gene polymorphism: the good, the bad and the ugly. Cardiovascular Research. 1999;43:23–24[Free Full Text]
  18. Lancet. 2000;355:253–259[CrossRef][ISI][Medline]
  19. Tiret L, Rigat B, Visvikis S. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin 1-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet. 1992;51:197–205[ISI][Medline]
  20. Rieder MJ, Taylor SL, Clark AG, Nickerson DA. Sequence variation in the human angiotensin converting enzyme. Nat Genet. 1999;22:59–62[CrossRef][ISI][Medline]
  21. Villard E, Tiret L, Visvikis S, Rakotovao R, Cambien F, Soubrier F. Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis. Am J Hum Genet. 1996;58:1268–1278[ISI][Medline]
  22. Zhu X, Bouzekri N, Southam L. Linkage and association analysis of angiotensin i-converting enzyme (ace)-gene polymorphisms with ace concentration and blood pressure. Am J Hum Genet. 2001;68:1139–1148[CrossRef][ISI][Medline]
  23. Zhu X, McKenzie CA, Forrester T, Nickerson DA, Broeckel U, Schunkert H. Localization of a small genomic region associated with elevated ACE. Am J Hum Genet. 2000;67:1144–1153[ISI][Medline]
  24. Sagnella GA, Rothwell MJ, Onipinla AK, Wicks PD, Cook DG, Cappuccio FP. A population study of ethnic variations in the angiotensin-converting enzyme I/D polymorphism: relationships with gender, hypertension and impaired glucose metabolism. J Hypertens. 1999;17:657–664[CrossRef][ISI][Medline]
  25. Staessen JA, Ginocchio G, Wang JG, Saavedra AP, Soubrier F, Vlietinck R. Genetic variability in the renin-angiotensin system: prevalence of alleles and genotypes. J Cardiovasc Risk. 1997;4:401–422[Medline]
  26. Lester S, Heatley S, Bardy P, Bahnisch J, Bannister K, Faull R. The DD genotype of the angiotensin-converting enzyme gene occurs in very low frequency in Australian Aboriginals. Nephrol Dial Transplant. 1999;14:887–890[Abstract/Free Full Text]
  27. Beneteau-Burnat B, Baudin B, Morgant G, Baumann FC, Giboudeau J. Serum angiotensin-converting enzyme in healthy an sarcoidotic children: comparison with the reference interval for adults. Clin Chem. 1990;36:344–346[Abstract/Free Full Text]
  28. Ribichini F, Steffenino G, Dellavalle A, Matullo G, Colajanni E, Vado A. Plasma activity and insertion/deletion polymorphism of angiotensin I-converting enzyme: a major risk factor and a marker of risk of coronary stent restenosis. Circulation. 1998;97:147–154[Abstract/Free Full Text]
  29. Alhenc-Gelas F, Richard J, Courbon D, Warnet JM, Corvol P. Distribution of plasma angiotensin I-converting enzyme levels in healthy men: relationship to environmental and hormonal parameters. J Lab Clin Med. 1991;117:33–39[ISI][Medline]
  30. Jalil JE, Ocaranza MP, Piddo AM, Jalil R. Reproducibility of plasma angiotensin-converting enzyme activity in human subjects determined by fluorimetry with Z-phenylalanine-histidyle-leucine as substrate. J Lab Clin Med. 1999;133:510–516
  31. Fyhrquist F, Dessypris A, Immonen I. Marathon run: effects on plasma renin activity, renin substrate, angiotensin converting enzyme, and cortisol. Horm Metab Res. 1983;15:96–99[ISI][Medline]
  32. Odum CU, Pipkin FB. Studies on the effect of normal labour and obstetric analgaesia on maternal and cord venous plasma angiotensin converting enzyme activity in primagravidae. West Afr J Med. 1990;9:16–21[Medline]
  33. Hilgenfeldt U, Puschner T, Riester U, Finsterle J, Hilgenfeldt E JR. Low-salt diet downregulates plasma but not tissue kallikrein-kinin system. Am J Physiol. 1998;275:F88–F93[Medline]
  34. Costerousse O, Jaspard E, Wei L, Corvol P, Alhenc-Gelas F. The angiotensin I-converting enzyme (kininase II): molecular organization and regulation of its expression in humans. J Cardiovasc Pharmacol. 1992;20:S10–S15[Medline]
  35. Hooper NM. Angiotensin converting enzyme: implications from molecular biology for its physiological functions. Int J Biochem. 1991;23:641–647[CrossRef][ISI][Medline]
  36. Lieberman J, Sastre A. Angiotensin-converting enzyme activity in postmortem human tissues. Lab Invest. 1983;48:711–717[ISI][Medline]
  37. Haberbosch W, Bohle RM, Franke FE. The expression of angiotensin-1 converting enzyme in human atherosclerotic plaques is not related to the deletion/insertion polymorphism but to the risk of restenosis after cotronary interventions. Atherosclerosis. 1997;130:203–213[CrossRef][ISI][Medline]
  38. Schunkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS, Lorell BH. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy: effects on coronary resistance, contractility, and relaxation. J Clin Invest. 1990;86:1913–1920[ISI][Medline]
  39. Bruckschlegel G, Holmer SR, Jndeleit K. Blockade o f the renin-angiotensin system in cardiac pressure-overload hypertrophy in rats. Hypertension. 1995;25:250–259[Abstract/Free Full Text]
  40. Pfeifer M, Bruckschlegel G, Holmer S, Paul M, Riegger A, Schunkert H. Reciprocal regulation of pulmonary and cardiac angiotensin-converting enzyme in rats with severe left ventricular hypertrophy. Cardiovasc Res. 1998;38:125–132[Abstract/Free Full Text]
  41. Schunkert H, Hense HW, Muscholl M. Associations between circulating components of the renin-angiotensin-aldosterone system and left ventricular mass. Heart. 1997;77:24–31[Abstract/Free Full Text]
  42. Oosterga M, Voors AA, de Kam PJ. Plasma angiotensin-converting enzyme activity and left ventricular dilation after myocardial infarction. Circulation. 1997;95:2607–2609[Abstract/Free Full Text]
  43. Tarnow L, Cambien F, Rossing P. Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients. Diabetes. 1995;44:489–494[Abstract]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
HypertensionHome page
C. M. Kammerer, N. Gouin, P. B. Samollow, J. F. VandeBerg, J. E. Hixson, S. A. Cole, J. W. MacCluer, and L. D. Atwood
Two Quantitative Trait Loci Affect ACE Activities in Mexican-Americans
Hypertension, February 1, 2004; 43(2): 466 - 470.
[Abstract] [Full Text] [PDF]


This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Montgomery, H.
Right arrow Articles by Danilov, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Montgomery, H.
Right arrow Articles by Danilov, S.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?