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European Heart Journal 2002 23(24):1898-1899; doi:10.1053/euhj.2002.3374
Copyright © 2002 by the European Society of Cardiology.
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Editorials

New tricks for an old drug

M. Frenneaux

University of Wales College of Medicine, Cardiff, Wales, U.K.

References

  1. Willoughby SR, Stewart S, Chirkov YY, Kennedy JA, Holmes AS, Horowitz JD. Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. Eur Heart J. 2002;23:1946–1955[Abstract/Free Full Text]
  2. Chirkov YY, Holmes AS, Willoughby SR. Stable angina and acute coronary syndromes are associated with nitric oxide resistance in platelets. J Am Coll Cardiol. 2001;37:1851–1857[Abstract/Free Full Text]
  3. Folts JD, Stamler J, Loscalzo J. Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries. Circulation. 1991;83:2122–2127[Abstract/Free Full Text]
  4. Chirkov YY, Holmes AS, Chirkova LP, Horowitz JD. Nitrate resistance in platelets from patients with stable angina pectoris. Circulation. 1999;100:129–134[Abstract/Free Full Text]
  5. Anfossi G, Mularoni EM, Burzacca S. Platelet resistance to nitrates in obesity and obese NIDDM, and normal platelet sensitivity to both insulin and nitrates in lean NIDDM. Diabetes Care. 1998;21:121–126[Abstract]
  6. Maguire SM, Nugent AG, McGurk C, Johnston GD, Nicholls DP. Abnormal vascular responses in human chronic cardiac failure are both endothelium dependent and endothelium independent. Heart. 1998;80:141–145[Abstract/Free Full Text]
  7. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899–1906[Abstract/Free Full Text]
  8. Brown MJ, Horowitz JD, Mashford ML. A double-blind trial of perhexiline maleate in the prophylaxis of angina pectoris. Med J Aust. 1976;1:260–263[Web of Science][Medline]
  9. Cole PL, Beamer AD, McGowan N. Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent. Circulation. 1990;81:1260–1270[Abstract/Free Full Text]
  10. Stewart S, Voss DW, Northey DL, Horowitz JD. Relationship between plasma perhexiline concentration and symptomatic status during short-term perhexiline therapy. Ther Drug Monit. 1996;18:635–639[CrossRef][Web of Science][Medline]
  11. Kennedy JA, Unger SA, Horowitz JD. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochem Pharmacol. 1996;52:273–280[CrossRef][Web of Science][Medline]
  12. Stanley WC, Lopaschuk GD, Hall JL, McCormack JG. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res. 1997;33:243–257[Free Full Text]
  13. Bagger JP, Botker HE, Thomassen A, Nielsen TT. Effects of ranolazine on ischemic threshold, coronary sinus blood flow, and myocardial metabolism in coronary artery disease. Cardiovasc Drugs Ther. 1997;11:479–484[CrossRef][Web of Science][Medline]
  14. Kantor PF, Lucien A, Kozak R, Lopaschuk GD. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000;86:580–588[Abstract/Free Full Text]
  15. Schmidt-Schweda S, Holubarsch C. First clinical trial with etomoxir in patients with chronic congestive heart failure. Clin Sci (Lond). 2000;99:27–35[Medline]
  16. Szwed H, Sadowski Z, Elikowski W. Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand. Eur Heart J. 2001;22:2267–2274[Abstract/Free Full Text]
  17. Luccioni, R, Vague, P, Luccioni, F et al, Abnormalities of insulin secretion in coronary patients: effects of perhexiline maleate. Perhexiline maleate, Amsterdam, Excerpta Medica, 1978, 71, 88
  18. Ellis GR, Anderson RA, Chirkov YY. Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure. J Cardiovasc Pharmacol. 2001;37:564–570[CrossRef][Web of Science][Medline]
  19. Vera JC, Rivas CI, Fischbarg J, Golde DW. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid. Nature. 1993;364:79–82[CrossRef][Medline]
  20. Ng LL, Ngkeekwong FC, Quinn PA, Davies JE. Uptake mechanisms for ascorbate and dehydroascorbate in lymphoblasts from diabetic nephropathy and hypertensive patients. Diabetologia. 1998;41:435–442[CrossRef][Web of Science][Medline]
  21. Welch RW, Wang Y, Crossman A Jr, Park JB, Kirk KL, Levine M. Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms. J Biol Chem. 1995;270:12584–12592[Abstract/Free Full Text]

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This Article
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Right arrow Articles by Frenneaux, M.
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Right arrow Articles by Frenneaux, M.
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