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European Heart Journal 2002 23(5):405-413; doi:10.1053/euhj.2001.2806
Copyright © 2002 by the European Society of Cardiology.
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Morphological and mechanical information of coronary arteries obtained with intravascular elastography. Feasibility study in vivo

C.L. de Kortea,f1, S.G. Carliera, F. Mastika, M.M. Doyleya,b, A.F.W. van der Steena,b, P.W. Serruysa and N. Boma,b

a Experimental Echocardiography, Thoraxcentre, Erasmus University Rotterdam, The Netherlands
b Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands

revised May 11, 2001; accepted May 16, 2001

Abstract

Aims Plaque composition is a major determinant of coronary related clinical syndromes. In vitro experiments on human coronary and femoral arteries have demonstrated that different plaque types were detectable with intravascular ultrasound elastography. The aim of this study was to investigate the feasibility of applying intravascular elastography during interventional catheterization procedures.

Methods and Results Data were acquired in patients (n=12) during PTCA procedures with an EndoSonics InVision echoapparatus equipped with radiofrequency output. The systemic pressure was used to strain the tissue, and the strain was determined using cross-correlation analysis of sequential frames. A likelihood function was determined to obtain the frames with minimal motion of the catheter in the lumen, since motion of the catheter prevents reliable strain estimation. Minimal motion was observed near end-diastole. Reproducible strain estimates were obtained within one pressure cycle and over several pressure cycles. Validation of the results was limited to the information provided by the echogram. Strain in calcified material (0·20%±0·07) was lower (P<0·001) than in non-calcified tissue (0·51%±0·20).

Conclusion In vivo intravascular elastography is feasible. Significantly higher strain values were found in non-calcified plaques than in calcified plaques.

Key Words: IVUS elastography, atherosclerosis, coronary artery disease, ultrasound

f1 Correspondence: Chris L. de Korte, Exp.Echo. Ee23.02, PO Box 1738, 3000 DR Rotterdam, The Netherlands.

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