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European Heart Journal 1989 10(7):676-677;
Copyright © 1989 by the European Society of Cardiology.
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© 1989 The European Society of Cardiology

Familial aortic valve disease: evidence for a genetic influence?

K. MCDONALD*, and B. J. MAURER{dagger}

St Vincent's Hospital and University College Dublin Ireland

Received 13 June 1988; revised 6 December 1988; .

Address for correspondence: Dr K. McDonald, Box 508 UMHC, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, U.S.A.

Abstract

It has been suggested that genetic factors may play a role in the aetiology of congenital bicuspid aortic valve disease. This report describes a family in which three male siblings with bicuspid aortic valves developed critical aortic stenosis. This provides further evidence that an hereditary mechanism may play a role in some patients with this condition.

Key Words: Aortic valve stenosis • hereditary diseases


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