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European Heart Journal 1990 11(11):1041-1048;
Copyright © 1990 by the European Society of Cardiology.
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© 1990 The European Society of Cardiology

Hypertrophic obstructive cardiomyopathy and infective endocarditis: A report of seven cases and a review of the literature

N. ALESSANDRI, G. PANNARALE, F. DEL MONTE, F. MORETTI, B. MARINO and A. REALE

II Cattedra Malattie Apparato Cardiovascolare, Universit{acute} ‘La Sapienza’ Roma, Italy

Received 12 October 1989; revised 12 February 1990; .

Address for correspondence: Nicola Alessandn, Via deila Moletta, 17, 00154 Roma, Italy.

Abstract

Seven cases of infective endocarditis (IE) in patients with hypertrophic obstructive cardiomyopathy (HOCM) are presented in this report. The previous literature is critically reviewed, and the following points are discussed: (a) IE complicates HOCM in 5-9% of cases; (b) anatomical and haemodynamic alterations of HOCM cause microtraumas on heart valves and the endocardium; the resulting endocardial lesions represent sites for bacterial seeding as well as other congenital or acquired heart disease; (c) prognosis is worse in patients with IE associated with HOCM than in patients with IE alone or associated with congenital heart disease; (d) the most frequently isolated organisms are saprophytes; (e) most patients were exposed to bacteraemias before the onset of IE.

Key Words: Hypertrophic obstructive cardiomyopathy • infective endocarditis


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