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European Heart Journal 1994 15(3):335-338;
Copyright © 1994 by the European Society of Cardiology.
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© 1994 The European Society of Cardiology

Chrome congestive heart failure

Activation and destruction of platelets in patients with rheumatic heart disease

S. KUNISHIMA*,, M. HATTORI{dagger}, S. KOBAYASHI*, H. HATTORI{dagger}, Y. IWAMA{dagger}, Y. IMAI{dagger}, K. OGAWA{dagger}, T. NAOE{ddagger} and R. OHNO{ddagger}

*Departments of Central Clinical Laboratory 1–3–1 Sannomaru, Naka-ku, Nagoya 460
{dagger}Cardiology, Meijo Hospital 1–3–1 Sannomaru, Naka-ku, Nagoya 460
{ddagger}Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine 1–1–20 Daiko-Minami, Higashi-ku, Nagoya 461, Japan

Received 10 November 1992; revised 25 October 1993; .

Correspondence: Shinji Kunishisna, Department of Central Clinical Laboratory, Meijo Hospital, 1-3-1 Sannomaru, Naka-ku, Nagoya 460, Japan

Abstract

We evaluated the activation and destruction of platelets in 24 patients with rheumatic heart disease (RHD) involving the mitral valve. Ex vivo platelet aggregation induced by adenosine diphosphate (ADP) and collagen was significantly increased in RHD patients as compared with normal controls. Plasma levels of ß-thromboglobulin (ß-TG) and platelet factor 4 were also elevated Plasma concentrations of glycocalicin, a proteolytic fragment of platelet membrane glycoprotein Ib. were increased, while platelet counts were decreased in RHD patients as compared with normal controls. RHD patients with, versus those without, atrial fibrillation demonstrated significant differences in ß-TG levels and platelet counts. However, we observed no difference in glycocalicin levels between the two groups. The present study demonstrated that increased platelet activation, as well as platelet destruction, occur in patients with RHD.

Key Words: Atrial fibrillation • glycocalicin • glycoprotein Ib • platelet aggregation • platelet factor 4 • ß-thromboglobulin


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