Skip Navigation

European Heart Journal 1994 15(9):1274-1278;
Copyright © 1994 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by OLLITRAULT, J.
Right arrow Articles by GUIZE, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by OLLITRAULT, J.
Right arrow Articles by GUIZE, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1994 The European Society of Cardiology

Single infusion of intravenous cibenzoline in the treatment of supraventricular tachyarrhythmias following heart surgery:

A double-blind placebo-controlled paralled study

J. OLLITRAULT*,, L. QUILLIET{dagger}, F. SCHECK{ddagger}, B. LELONG§, A. RICHARD||, G. JARRY and L. GUIZE**

*Service de cardiologie, Hôpital St Joseph Paris
{dagger}Service de chirurgie cardiaque, Hôpital Trousseau Tours
{ddagger}Laboratoire UPSA Rueil Malmaison
§Service de chirurgie cardio-thoracique, Hôpital Pontchaillou Rennes
||Service de cardiologie, C. H. R. Clermont Ferrand
Service de cardiologie A, Hôpital Sud Amiens
**Service de cardiologie, Hôpital Broussais Paris, France

Received 5 November 1993; revised 1 April 1994; .

Correspondence: Jacky Ollitrault, MD, Service de cardiologie, Höpital St Joseph, 7 rue Pierre Larousse, 75014 Paris, France.

Abstract

The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%) with placebo (P<0.05). In the non-converted patients, ventricular rate was significantly slowed by cibenzoline (P<0.05), which also significantly increased the duration of QRS and QT intervals. Transient adverse events were seen in nine patients receiving cibenzoline: moderate hypotension, sweating, right bundle branch block. One patient with decreased left ventricular function had an increased ventricular rate and QRS duration associated with hypotension. There were no severe adverse events. These results suggest that cibenzoline is effective for the treatment of postoperative supraventricular tachyarrhythmias in patients without impairment of ventricular function.

Key Words: Cibenzoline • supraventricular tachyarrhythmias • heart surgery


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.