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European Heart Journal 1995 16(9):1177-1180;
Copyright © 1995 by the European Society of Cardiology.
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© 1995 The European Society of Cardiology

The prognostic value of exercise testing early after myocardial infarction in patients treated with thrombolytics

E. TOFT*, G. NIELSEN*, B. MORTENSEN*, J. AARØE*, D. DALSGAARD*, J. B. HANSEN*, S. JUUL{dagger} and K. RASMUSSEN*

*Department of Cardiology, Aalborg Hospital Aalborg
{dagger}Institute of Epidemiology and Social Medicine, Århus University Århus, Denmark

revised 1 September 1994; accepted 28 October 1994.

Correspondence. Egon Toft, Blegdalsparken 102, DK-9000, Aalborg, Denmark.

Abstract

Exercise testing early post A MI was evaluated as a predictor of re infarction in patients treated with thrombolytics. AMI patients exercise-tested prior to discharge were included in the study (n = 178). The patients were followed for 2.9±0.9 years (mean±1 SD) for the development of new cardiac events defined as cardiac death or reinfarction. Cox regression analysis of clinical and exercise test variables showed that there was significant predictive value of treating heart failure with drugs from two or more therapeutic groups (P<0.001; hazard ratio 9.4 (3.1–28.2) (estimate and 95% confidence interval)), such as those with a previous history of myocardial infarction (P = 0.001; hazard ratio 4.0 (1.7–9.6)) and of significant ST depression (P = 0.029; hazard ratio 2.5 (1.1–5.7)). Significant ST depression could be substituted by the {bigtriangleup}ST/{bigtriangleup}HR index (P = 0.042; hazard ratio 2.8 (1.2–6.8)).

The exercise test had independent but limited prognostic value in AMI patients treated with thrombolytics. The {bigtriangleup}ST/{bigtriangleup}HR index did not improve the predictive value of the exercise test.

Key Words: Thrombolysis • prognosis • AMI • exercise test • ST segment depression • {bigtriangleup}ST/{bigtriangleup}HR index


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L. Abboud, J. Hir, I. Eisen, A. Cohen, and W. Markiewicz
Long-term Value of Exercise Testing After Acute Myocardial Infarction: Influence of Thrombolytic Therapy
Chest, February 1, 2000; 117(2): 556 - 561.
[Abstract] [Full Text] [PDF]


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