Skip Navigation

European Heart Journal 1998 19(11):1657-1665; doi:10.1053/euhj.1998.1097
Copyright © 1998 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (27)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gardemann, A.
Right arrow Articles by Haberbosch, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gardemann, A.
Right arrow Articles by Haberbosch, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Angiotensin II type 1 receptor A1166C gene polymorphism

Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases

A. Gardemanna, Q.D. Nguyena, J. Hummea, J. Strickera, N. Katza, H. Tillmannsb, F.W. Hehrleinc, M. Raud and W. Haberboschd

a Institut für Klinische Chemie und Pathobiochemie, Giessen
b Abteilung Kardiologie und Angiologie, Giessen
c Klinik für Herz- und Gefäßchirurgie der Justus-Liebig-Universität Giessen, Giessen
d Max-Planck-Institut für Experimentelle und Klinische Forschung, Kerckhoff-Klinik, Bad Nauheim, Germany

accepted March 30, 1998

Aim

There is evidence that interaction between angiotensin II type 1 receptor A1166C gene polymorphism and angio-tensin I-converting enzyme Insertion/Deletion gene variation might have an effect on the risk of myocardial infarction. The study was carried out in a population of 2244 male Caucasians, whose coronary anatomy was defined by means of coronary angiography. We analysed the relationship, on the risk of ischaemic heart disease, of angiotensin II type 1 receptor A1166C gene variation, not only to myocardial infarction but also to coronary artery disease, and its potential interaction with angio-tensin I-converting enzyme Insertion/Deletion gene polymorphism.

Methods and Results

No association was detected between angiotensin II type 1 receptor A1166C gene polymorphism and coronary artery disease. Similarly, there was no link to myocardial infarction, either in the total population or in low risk groups. In addition, most importantly, we found no interaction between angiotensin II type 1 receptor A1166C gene variation and angiotensin I-converting Insertion/Deletion polymorphism, either in connection with the risk of coronary artery disease or myocardial infarction.

Conclusion

This angiotensin II type 1 receptor A1166C gene variation is not associated with any detectable increase in risk of ischaemic heart disease. The findings of the present study do not suggest that, as regards risk of coronary artery disease and myocardial infarction, there is interaction between gene polymorphism and angiotensin I-converting enzyme Insertion/Deletion gene variation.The European Society of Cardiology

Key Words: Angiotensin II type 1 receptor A1166C gene polymorphism • angiotensin I-converting enzyme Insertion/Deletion gene polymorphism • cardiovascular disease • myocardial infarction • risk factors • renin–angiotensin–aldosterone system

Correspondence: Andreas Gardemann, Institut für Klinische Chemie und Pathobiochemie, Klinikum der Justus-Liebig-Universität Gießen, Gaffky-Strasse 11, 35392 Gießen, Germany.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
E. E. Ntzani, E. C. Rizos, and J. P. A. Ioannidis
Genetic Effects versus Bias for Candidate Polymorphisms in Myocardial Infarction: Case Study and Overview of Large-Scale Evidence
Am. J. Epidemiol., May 1, 2007; 165(9): 973 - 984.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Jones, S. S. Dhamrait, J. R. Payne, E. Hawe, P. Li, I. S. Toor, L. Luong, P. T.E. Wootton, G. J. Miller, S. E. Humphries, et al.
Genetic Variants of Angiotensin II Receptors and Cardiovascular Risk in Hypertension
Hypertension, October 1, 2003; 42(4): 500 - 506.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
B. R. Palmer, A. P. Pilbrow, T. G. Yandle, C. M. Frampton, A. M. Richards, M. G. Nicholls, and V. A. Cameron
Angiotensin-converting enzyme gene polymorphism interacts with left ventricular ejection fraction and brain natriuretic peptide levels to predict mortality after myocardial infarction
J. Am. Coll. Cardiol., March 5, 2003; 41(5): 729 - 736.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
P P van Geel, Y M Pinto, A H Zwinderman, R H Henning, A J van Boven, J W Jukema, A V G Bruschke, J J P Kastelein, W H van Gilst, and G F BAXTER
Increased risk for ischaemic events is related to combined RAS polymorphism
Heart, April 1, 2001; 85(4): 458 - 462.
[Abstract] [Full Text]

Home page
 HypertensionHome page
C. K. Naber, J. Husing, U. Wolfhard, R. Erbel, and W. Siffert
Interaction of the ACE D Allele and the GNB3 825T Allele in Myocardial Infarction
Hypertension, December 1, 2000; 36(6): 986 - 989.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
D. Crisan and J. Carr
Angiotensin I-Converting Enzyme: Genotype and Disease Associations
J. Mol. Diagn., August 1, 2000; 2(3): 105 - 115.
[Full Text]

Home page
 HypertensionHome page
P. P. van Geel, Y. M. Pinto, A. A. Voors, H. Buikema, M. Oosterga, H. J. G. M. Crijns, and W. H. van Gilst
Angiotensin II Type 1 Receptor A1166C Gene Polymorphism Is Associated With an Increased Response to Angiotensin II in Human Arteries
Hypertension, March 1, 2000; 35(3): 717 - 721.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Gardemann, H. Weidemann, M. Philipp, N. Katz, H. Tillmanns, F. W. Hehrlein, and W. Haberbosch
The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease
Eur. Heart J., April 2, 1999; 20(8): 584 - 592.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.