Copyright © 2000 by the European Society of Cardiology.
Transcatheter closure of multiple atrial septal defects. Initial results and value of two- and three-dimensional transoesophageal echocardiography
a Division of Cardiology, Department of Pediatrics, Floaating Hospital for Children at New England Medical Center, Tufts University School of Medicine, Boston, MA, U.S.A.
b Department of Pediatrics, Medical University of South Carolina, Charleston, SC, U.S.A.
c Deutsches Herzzentrum Berlin, Berlin, Germany
d Department of Pediatrics, The University of Chicago Children's Hospital, Chicago, IL, U.S.A.
Abstract
Aims To examine the feasibility of transcatheter closure of multiple atrial septal defects using two Amplatzer devices simultaneously and to describe the importance and the role of two- and three-dimensional transoesophageal echocardiography in the selection and closure of such defects.
Methods Twenty-two patients with more than one atrial septal defect underwent an attempt at transcatheter closure of their atrial septal defects at a mean±SD age of 30·8±18·6 years (range 3·7–65·9 years) and mean weight of 56·6±25·5kg (range 12·9–99kg) using two Amplatzer devices implanted simultaneously via two separate delivery systems. During catheterization, two dimensional transoesophageal echocardiography was performed in all but one patient, during and after transcatheter closure, while three dimensional transoesophageal echocardiography was performed in six patients before and after transcatheter closure.
Results Forty-four devices were deployed in all patients to close 45 defects (one patient with three defects closed by two devices). Two dimensional transoesophageal echocardiography was helpful in selection and in guiding correct deployment of the devices. The mean size of the larger defect, as measured by transoesophageal echocardiography was 12·8±5·9mm and the mean size of the smaller defect was 6·6±3·0mm. The mean size of the larger devices was 15±7·5mm, and 8·4±3·7mm for the smaller. Three dimensional transoesophageal echocardiography provided superior imaging and demonstrated the number, shape and the surrounding structures of the atrial septal defects in one single view. The median fluoroscopy time was 28·7 min. Device embolization with successful catheter retrieval occurred in one patient. Forty-four devices were evaluated by colour Doppler transoesophageal echocardiography immediately after the catheterization with a successful closure rate of 97·7%. On follow-up colour Doppler transthoracic echocardiography demonstrated successful closure in 97·5% at 3 months.
Conclusions The use of more than one Amplatzer septal occluder to close multiple atrial septal defects is safe and effective. The use of two- and three-dimensional transoesophageal echocardiography provided useful information for transcatheter closure of multiple atrial septal defects using two devices. Three-dimensional transoesophageal echocardiography enhanced our ability to image and understand the spatial relationship of the atrial septal defect anatomy.
Key Words: Multiple atrial septal defects, Amplatzer septal occulder, echocardiography
f1 Correspondence: Z. M. Hijazi, MD Professor, Chief of Pediatric Cardiology, The University of Chicago Children’s Hospital, 5841 South Maryland Ave., MC4051, Chicago, IL 60637, U.S.A.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Arcidiacono, G. Gaio, G. Butera, and M. Carminati Percutaneous Closure of Multiple Secundum Atrial Septal Defects Using 3 Amplatzer Atrial Septal Occluder Devices: Evaluation by Live Transthoracic 3-Dimensional Echocardiography Circ Cardiovasc Imaging, September 1, 2008; 1(2): e15 - e16. [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Diab, Q.-L. Cao, E. A. Bacha, and Z. M. Hijazi Device closure of atrial septal defects with the Amplatzer septal occluder: Safety and outcome in infants. J. Thorac. Cardiovasc. Surg., October 1, 2007; 134(4): 960 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Lang, V. Mor-Avi, L. Sugeng, P. S. Nieman, and D. J. Sahn Three-Dimensional Echocardiography: The Benefits of the Additional Dimension J. Am. Coll. Cardiol., November 21, 2006; 48(10): 2053 - 2069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Y. Lee, M. J. Siegel, C. M. Chu, F. R. Gutierrez, and H. W. Kort Amplatzer Atrial Septal Defect Occluder for Pediatric Patients: Radiographic Appearance Radiology, November 1, 2004; 233(2): 471 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Suematsu, S. Takamoto, Y. Kaneko, T. Ohtsuka, H. Takayama, Y. Kotsuka, and A. Murakami Beating Atrial Septal Defect Closure Monitored by Epicardial Real-Time Three-Dimensional Echocardiography Without Cardiopulmonary Bypass Circulation, February 11, 2003; 107(5): 785 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-D. Du, Z. M. Hijazi, C. S. Kleinman, N. H. Silverman, K. Larntz, and Amplatzer Investigators Comparison between transcatheter and surgical closure of secundum atrial septal defect in children and adults: Results of a multicenter nonrandomized trial J. Am. Coll. Cardiol., June 5, 2002; 39(11): 1836 - 1844. [Abstract] [Full Text] [PDF]
|
|