Copyright © 2000 by the European Society of Cardiology.
Mitral flow derived Doppler indices of left ventricular diastolic function in a general population. The Tromsø study
a Institute of Community Medicine, Institute of Clinical Medicine, University of Tromsø Norway
b Institute of Clinical Medicine, University of Tromsø Norway
revised December 13, 1999; accepted December 15, 1999
Abstract
Aims Left ventricular diastolic dysfunction has been proposed as the basis of heart failure in patients with normal left ventricular systolic function. Doppler indices of mitral inflow have been widely used to diagnose this condition and have been shown to correlate well with increased left atrial pressure in patients with cardiovascular disease. We wanted to establish age-specific criteria for normality of these indices in a large population and to determine the association of abnormal values to age and cardiovascular disease.
Methods and Results In our sample of subjects aged 25–85 years, 3022 had pulsed Doppler measurements of mitral inflow velocities and early inflow deceleration time. The association of these indices to age and gender were established in a ‘healthy’ reference subsample of 949 subjects. Age-specific percentiles showed a significant decline with increasing age for peak early mitral inflow velocity and the ratio of peak early and atrial inflow velocities (E/A ratio), whereas early inflow deceleration time and peak atrial inflow velocity showed a significant increase with increasing age. According to current criteria for diastolic dysfunction, the prevalence of dysfunction decreases with increasing age in the general population, as well as in the subgroup with cardiovascular disease. Only 7% of the variance in deceleration time was explained by cardiovascular disease or risk factors. For the E/A ratio, however, 41 and 48% of the variance were explained for men and women, respectively.
Conclusion Age- and gender-specific criteria for normality are provided. Our data confirm the existence of a significant effect of age and gender on mitral Doppler indices of diastolic dysfunction. However, Doppler criteria for diastolic dysfunction based on these measurements need revision.
Key Words: Echocardiography, population, Doppler, heart failure, diastolic function
f1 Correspondence: Henrik Schirmer, Institute of Community Medicine, University of Tromsø, 9037 Tromsø, Norway.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Kuznetsova, L. Herbots, B. Lopez, Y. Jin, T. Richart, L. Thijs, A. Gonzalez, M.-C. Herregods, R. H. Fagard, J. Diez, et al. Prevalence of Left Ventricular Diastolic Dysfunction in a General Population Circ Heart Fail, March 1, 2009; 2(2): 105 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Zhang, G. W.-K. Yip, and C.-M. Yu Approaching regional left atrial function by tissue Doppler velocity and strain imaging Europace, November 1, 2008; 10(suppl_3): iii62 - iii69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Bierig, A. Ryan, A. Ziaee, L. Kociolek, J. Simon, S. Herrmann, and A. J. Labovitz Serial changes in systolic and diastolic echocardiographic indices as predictors of outcome in patients with decreased left ventricular ejection fraction Eur J Echocardiogr, October 1, 2007; 8(5): 369 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Iqbal, H. Schirmer, P. Lunde, Y. Figenschau, K. Rasmussen, and R. Jorde Thyroid Stimulating Hormone and Left Ventricular Function J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3504 - 3510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. W. Nielsen, A. Sajedieh, F. Petersen, and J. Fischer Hansen Value of left ventricular filling parameters to predict mortality and functional class in patients with heart disease from the community Eur J Echocardiogr, March 1, 2005; 6(2): 85 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Pedersen, I. Raymond, L. H. Madsen, J. Mehlsen, D. Atar, and P. Hildebrandt Echocardiographic indices of left ventricular diastolic dysfunction in 647 individuals with preserved left ventricular systolic function Eur J Heart Fail, June 1, 2004; 6(4): 439 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Phillip, D. Pastor, W. Bellows, and J. M. Leung The Prevalence of Preoperative Diastolic Filling Abnormalities in Geriatric Surgical Patients Anesth. Analg., November 1, 2003; 97(5): 1214 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Oxenham and N. Sharpe Cardiovascular aging and heart failure Eur J Heart Fail, August 1, 2003; 5(4): 427 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Muiesan, M. Lupia, M. Salvetti, C. Grigoletto, N. Sonino, M. Boscaro, E. A. Rosei, F. Mantero, and F. Fallo Left ventricular structural and functional characteristics in Cushing's syndrome J. Am. Coll. Cardiol., June 18, 2003; 41(12): 2275 - 2279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Peterson, M. R. Rinder, K. B. Schechtman, R. J. Spina, K. L. Glover, D. T. Villareal, and A. A. Ehsani Peak exercise stroke volume: associations with cardiac structure and diastolic function J Appl Physiol, March 1, 2003; 94(3): 1108 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schillaci, L. Pasqualini, P. Verdecchia, G. Vaudo, S. Marchesi, C. Porcellati, G. de Simone, and E. Mannarino Prognostic significance of left ventricular diastolic dysfunction in essential hypertension J. Am. Coll. Cardiol., June 19, 2002; 39(12): 2005 - 2011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lonnerholm, P. Blomstrom, L. Nilsson, and C. Blomstrom-Lundqvist Atrial size and transport function after the Maze III procedure for paroxysmal atrial fibrillation Ann. Thorac. Surg., January 1, 2002; 73(1): 107 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. St. John Sutton Mitral flow derived Doppler indices of left ventricular diastolic function Eur. Heart J., August 2, 2000; 21(16): 1298 - 1300. [PDF]
|
|