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European Heart Journal 2000 21(19):1566-1567; doi:10.1053/euhj.2000.2271
Copyright © 2000 by the European Society of Cardiology.
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Editorial

The Edinburgh Artery Study: is lytic activity bad for the heart?

P.J. Grant

Academic Unit of Molecular Vascular Medicine, The General Infirmary, Leeds, U.K.

References

  1. Smith FB, Fowkes FGR, Rumley A, Lee AJ, Lowe GDO, Hau CM. Tissue plasminogen activator and leucocyte elastase as predictors of cardiovascular events in subjects with angina pectoris: Edinburgh Artery Study. Eur Heart J. 2000;21:1607–1613[Abstract/Free Full Text]
  2. Thompson SG, Kienast J, Pyke SDM, Haverkate F, Van De Loo J. Haemostatic factors and the risk of myocardial infarction or sudden death in patients with myocardial infarction. N Engl J Med. 1995;332:635–641[Abstract/Free Full Text]
  3. Ridker PM, Vaughan DE, Stampfer MJ, Manson JE, Hennekens CH. Endogenous tissue-type plasminogen activator and risk of myocardial infarction. Lancet. 1993;341:1165–1168[CrossRef][ISI][Medline]
  4. Lowe GDO, Yarnell JWG, Sweetnam PM, Rumley A, Thomas HF, Elwood PC. Fibrin D-Dimer, tissue plasminogen activator, plasminogen activator inhibitor and the risk of major ischaemic heart disease in the Caerphilly Study. Thromb Haemost. 1998;79:129–133[ISI][Medline]
  5. Ridker PM, Hennekens CH, Cerskus A, Stampfer MJ. Plasma concentration of cross-linked fibrin degradation product (D-dimer) and the risk of future myocardial infarction among apparently healthy men. Circulation. 1994;90:2236–2240[Abstract/Free Full Text]
  6. Morrison HM, Welgus HG, Owen CA, Stockley RA, Campbell EJ. Interaction between leukocyte elastase and elastin: quantitative and catalytic analyses. Biochim Biophys Acta. 1999;1430:179–190[CrossRef][Medline]
  7. Stockley RA. New approaches to the management of COPD. Chest. 2000;117:58S–62S[Abstract/Free Full Text]
  8. Knight KR, Burdon JG, Cook L, Brentonr S, Ayad M, Janus ED. The proteinase-antiproteinase theory of emphysema: a speculative analysis of recent advances into the pathogenesis of emphysema. Respirology. 1997;2:91–95[Medline]
  9. Blann AD, Seigneur M, Adams RA, McCollum CN. Neutrophil elastase, von Willebrand factor, soluble thrombomodulin and percutaneous oxygen in peripheral atherosclerosis. Eur J Vasc Endovasc Surg. 1996;12:218–222[CrossRef][ISI][Medline]
  10. Tiefenbacher CP, Ebert M, Niroomand F. Inhibition of elastase improves myocardial infarction after repetitive ischaemia and myocardial infarction in the rat heart. Eur J Physiol. 1997;433:563–570[CrossRef][ISI][Medline]

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