Copyright © 2000 by the European Society of Cardiology.
Long-term results after aortic valve replacement in patients with congestive heart failure. Homografts vs prosthetic valves
Department of Cardiology and Academic Department of Cardiac Surgery, Harefield Hospital, Harefield, Middlesex, U.K.
revised November 29, 1999; accepted December 1, 1999
Abstract
Objectives The aim of this study was to assess the influence of valve substitute (homograft vs prosthetic valve) on the long-term survival and late valve-related complication rates following aortic valve replacement in patients with aortic valve disease and congestive heart failure.
Background The effect of choice of valve substitute on outcome after aortic valve replacement in patients with pre-operative heart failure is unknown. The superior haemodynamic profile of homografts may be of particular benefit.
Methods We retrospectively analysed pre-operative, operative and follow-up data on 518 adults in functional classes III and IV, who, over the 25 years 1969–1993, had their initial aortic valve replacement at Harefield hospital. Follow-up conducted during 1996 to April 1997 and totalling 4439 patient-years was 96·1% complete. Using multivariate analysis, independent risk factors for different complications and mortality were defined.
Results Overall 5-, 10- and 20-year survival was 80±2%, 62±2% and 30±3%, respectively, with no significant difference between valve types. However, homografts (n=381) independently reduced the rate of serious complications and cardiac death, whereas mechanical valves were an independent adverse risk factor for late mortality. The rates of anticoagulant-related bleeding and thromboembolism were increased by mechanical valves, whereas primary tissue failure was the main complication of homografts.
Conclusions Long-term outcome of homograft aortic valve replacement in patients with congestive heart failure is acceptable, with a reduced rate of serious complications and cardiac death. Further improvements would be expected if the rate of primary tissue failure could be reduced.
Key Words: Homograft, aortic valve replacement, congestive heart failure
f1 Correspondence: Dr R. Grocott-Mason, C/O Heart Science Centre, Harefield Hospital, Harefield, Middlesex UB9 6JH, U.K.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Walther, V. Falk, J. Kempfert, M. A. Borger, J. Fassl, M. W.A. Chu, G. Schuler, and F. W. Mohr Transapical minimally invasive aortic valve implantation; the initial 50 patients Eur. J. Cardiothorac. Surg., June 1, 2008; 33(6): 983 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Walther, P. Simon, T. Dewey, G. Wimmer-Greinecker, V. Falk, M. T. Kasimir, M. Doss, M. A. Borger, G. Schuler, D. Glogar, et al. Transapical Minimally Invasive Aortic Valve Implantation: Multicenter Experience Circulation, September 11, 2007; 116(11_suppl): I-240 - I-245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Gauthier, J. G. Barton, M. M. Lane, and R. C. Elkins Pulmonary autografts in patients with severe left ventricular dysfunction Ann. Thorac. Surg., September 1, 2003; 76(3): 689 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bevilacqua, J. Gianetti, A. Ripoli, U. Paradossi, A. Giuseppe Cerillo, M. Glauber, M. L. Sacha Matteucci, M. Senni, A. Gamba, E. Quaini, et al. Aortic valve disease with severe ventricular dysfunction: stentless valve for better recovery Ann. Thorac. Surg., December 1, 2002; 74(6): 2016 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Palka, S. Harrocks, A. Lange, D. J. Burstow, and M. F. O'Brien Primary Aortic Valve Replacement With Cryopreserved Aortic Allograft: An Echocardiographic Follow-Up Study of 570 Patients Circulation, January 1, 2002; 105(1): 61 - 66. [Abstract] [Full Text] [PDF]
|
|