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European Heart Journal 2001 22(10):813-824; doi:10.1053/euhj.2000.2186
Copyright © 2001 by the European Society of Cardiology.
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Reviews

Immunological basis of the cardiac conduction and rhythm disorders

B Maischf1 and A.D Ristic

Department of Internal Medicine-Cardiology, Philipps University, Marburg, Germany

revised March 13, 2000; accepted March 15, 2000

Key Words: Antibodies, atrioventricular block, autoimmunity, congenital heart block, myocarditis, sick sinus syndrome

f1 Correspondence: Prof. Dr. Bernhard Maisch, Director, Department of Internal Medicine-Cardiology, Philipps University, Marburg, Baldingerstrasse 1, 35033 Marburg, Germany.

References

  1. James TN, Rupe CE, Monto RW. Pathology of the cardiac conduction system in systemic lupus erythematosus. Ann Intern Med. 1965;63:402–410[Abstract/Free Full Text]
  2. James TN, Birk RE. Pathology of the cardiac conduction system in polyarteritis nodosa. Arch Intern Med. 1966;117:561–567[Abstract/Free Full Text]
  3. James TN, Sherf L. Fine structure of the His bundle. Circulation. 1971;44:9–28[Abstract/Free Full Text]
  4. Fairfax A, Doniach D. Autoantibodies to cardiac conducting tissue and their characterization by immunofluorescence. Clin Exp Immunol. 1976;23:1–8[Web of Science][Medline]
  5. James TN. Sudden death in babies: new observations in the heart. Am J Cardiol. 1968;22:479–506[CrossRef][Web of Science][Medline]
  6. McCue CM, Mantakas ME, Tingelstad JB, Ruddy S. Congenital heart block in newborns of mothers with connective tissue disease. Circulation. 1977;56:82–90[Abstract/Free Full Text]
  7. Chameides L, Truex RC, Vetter V, Rashkind WJ, Galioto FM Jr, Noonan JA. Association of maternal systemic lupus erythematosus and congenital complete heart block. N Engl J Med. 1977;297:1204–1207[Abstract]
  8. Weston WL, Hannon C, Peebles C. A serological marker for neonatal lupus erythematosus. Br J Dermatol. 1982;107:377–382[CrossRef][Web of Science][Medline]
  9. Scott JS, Maddison PJ, Taylor PV, Esscher E, Scott O, Skinner RP. Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block. N Engl J Med. 1983;28:209–212
  10. Lee LA, Reed BR, Harmon C. Autoantibodies to SS-A/Ro in congenital heart block. Arthritis Rheum. 1983;20:S24
  11. Villecco AS, de Liberali E, Bianchi FB, Pisi E. Antibodies to cardiac conducting tissue and abnormalities of cardiac conduction in rheumatoid arthritis. Clin Exp Immunol. 1983;53:536–540[Web of Science][Medline]
  12. Volta U, Villecco AS, Bianchi FB. Antibodies to cardiac conducting tissue in progressive systemic sclerosis. Clin Exp Rheumatol. 1985;3:131–135[Web of Science][Medline]
  13. Maisch B, Lotze U, Schneider J, Kochsiek K. Antibodies to human sinus node in sick sinus syndrome. Pacing Clin Electrophysiol. 1986;9:1101–1109[CrossRef][Medline]
  14. Lotze U, Maisch B. Humoral immune response to cardiac conducting tissue. Springer Semin Immunopathol. 1989;11:409–422[Web of Science][Medline]
  15. Bacman S, Sterin-Borda L, Camusso JJ, Hubscher O, Arana R, Borda ES. Circulating antibodies against neurotransmitter receptor activities in children with congenital heart block and their mothers. FASEB J. 1994;8:1170–1176[Abstract]
  16. Li JM, Fan WS, Horsfall AC. The expression of human endogenous retrovirus-3 in foetal cardiac tissue and antibodies in congenital heart block. Clin Exp Immunol. 1996;104:388–393[Web of Science][Medline]
  17. James TN, Martin ES, Willis PW III, Lohr TO. Apoptosis as a possible cause of gradual development of complete heart block and fatal arrhythmias associated with absence of the atrioventricular node, sinus node, and internodal pathways. Circulation. 1996;93:1424–1438[Abstract/Free Full Text]
  18. Bergfeldt L, Möller E. Complete heart block—another HLAB27 associated disease manifestation. Tissue Antigens. 1983;21:385–389[Web of Science][Medline]
  19. Bergfeldt L, Vallin H, Edhag O. Complete heart block in HLAB27 associated disease. Electrophysiological and clinical characteristics. Br Heart J. 1984;51:184–188[Abstract/Free Full Text]
  20. Lang B, Wilhelm C, Gildein P, Vaith P, Schillinger H, Peter HH. Foetal complete heart block with myocarditis and maternal SS-A-/SS-B antibodies. Schweiz Med Wochenschr. 1990;120:1741–1744[Web of Science][Medline]
  21. Kasp-Grouchowska E, Kingston D. Streptococcal cross-reacting antigen and the bundle of His. Clin Exp Immunol. 1977;27:63–65[Web of Science][Medline]
  22. Maisch B, Bauer E, Cirsi M, Koschiek K. Cytolytic cross-reactive antibodies directed against the cardiac membrane and viral proteins in Coxsackie B3 and B4 myocarditis. Characterization and pathogenetic relevance. Circulation. 1993;87:49–65
  23. Horsfall AC, Rose LM. Cross-reactive maternal autoantibodies and congenital heart block. J Autoimmun. 1992;5:479–493[CrossRef][Web of Science][Medline]
  24. Li JM, Horsfall AC, Maini RN. Anti-La (SS-B) but not anti-Ro52 (SS-A) antibodies cross-react with laminin—a role in the pathogenesis of congenital heart block? Clin Exp Immunol. 1995;99:316–324[Web of Science][Medline]
  25. Reichlin M, Brucato A, Frank MB. Concentration of autoantibodies to native 60-kD Ro/SS-A and denatured 52-kD Ro/SS-A in eluates from the heart of a child who died with congenital complete heart block. Arthritis Rheum. 1994;37:1698–1703[Web of Science][Medline]
  26. Alexander E, Buyon JP, Provost TT, Guarnieri T. Anti-Ro/SS-A antibodies in the pathophysiology of congenital heart block in neonatal lupus syndrome, an experimental model. In vitro electrophysiologic and immunocytochemical studies. Arthritis Rheum. 1992;35:176–189[Web of Science][Medline]
  27. Garcia S, Nascimento JHM, Bonfa E, Oliveira SF, Tavares, Campos de Carvalho AC. Cellular mechanism of the conduction abnormalities induced by serum from anti Ro/SSA-positive patients in rabbit hearts. J Clin Invest. 1994;93:718–724[Web of Science][Medline]
  28. Boutjdir M, Zhang Z, Chen L, El-Sherif N. Electrophysiologic characterization of purified IgG from a mother whose child has congenital heart block (CHB) on L-type calcium currents (ICa). Arthritis Rheum. 1995;38:S230
  29. Huynh TV, Chen R, Wetael CT, Friedman WF, Klitzner TS. Developmental changes in membrane Ca2+and K+currents in foetal, neonatal and adult rabbit ventricular myocytes. Circ Res. 1992;70:508–515[Abstract/Free Full Text]
  30. Maylie JG. Excitation-contraction coupling in neonatal and adult myocardium of cat. Am J Physiol. 1982;242:H834–843
  31. Bilazarian SD, Taylor AJ, Brezinski D, Hochberg MC, Guarnieri T, Provost TT. High-grade atrioventricular heart block in an adult with systemic lupus erythematosus: the association of nuclear RNP (U1RNP) antibodies, a case report, and review of the literature. Arthritis Rheum. 1989;32:1170–1174[Web of Science][Medline]
  32. Dimitrijevic M, Vasiljevic Z, Vuckovic-Dekic L, Spasic S. The involvement of immune reactions in cardiac damage during acute myocardial infarction: role of cell-mediated immune response. Panminerva Med. 1997;39:85–94[Web of Science][Medline]
  33. Maione S, Valentin G, Giunta A. Cardiac involvement in rheumatoid arthritis. Cardiology. 1993;83:234–239[Web of Science][Medline]
  34. Fairfax MJ, Osborn JG, Williams GA. Endomyocardial biopsy in patients with systemic lupus erythematosus. J Rheumatol. 1988;15:593–596[Web of Science][Medline]
  35. Smeenk RJT, Feltkamp TEW. Anti-nuclear antibodies. Delves PJ, Roitt IM. Encyclopedia of Immunology. San Diego: Academic Press; 1998. p. 125–133
  36. Tseng CE, Caldwell K, Feit S, Chan EK, Buyon JP. Subclass distribution of maternal and neonatal anti-Ro(SSA) and La(SSB) antibodies in congenital heart block. J Rheumatol. 1996;23:925–932[Web of Science][Medline]
  37. Deng JS, Bair LW Jr, Shen-Schwarz S, Ramsey-Goldman R, Medsger T Jr. Localization of Ro(SS-A) antigen in the cardiac conduction system. Arthritis Rheum. 1987;30:1232–1238[Web of Science][Medline]
  38. Horsfall AC, Venables PJW, Taylor PV, Maini RN. Ro and La antigens and maternal autoantibody idiotype on the surface of myocardial fibres in congenital heart block. J Autoimmun. 1991;4:165–176[CrossRef][Web of Science][Medline]
  39. Mierau R, Genth E. Systemisch entzündlich-rheumatische Ertrankungen (Kollagenosen). Thomas L. Labor und Diagnose. Indikation und Bewertigung von Laborbefunden für die medizinische Diagnostik. Frankfurt am Main: TH-Books VmbH; 1998. p. 824–827
  40. Tsay GJ, Wang CL, Chen TY, Huang CN, Hsu TC. SS-A/Ro antibodies in Chinese patients with systemic lupus erythematosus and Sjoegren's syndrome. J Formos Med Assoc. 1996;95:905–910[Web of Science][Medline]
  41. Wang CL, Ooi L, Wang F. Prevalence and clinical significance of antibodies to ribonucleoproteins in systemic lupus erythematosus in Malaysia. Br J Rheumatol. 1996;35:129–132[Abstract/Free Full Text]
  42. Taylor P, Taylor KF, Norman A, Griffiths S, Scott JS. Prevalence of maternal Ro(SS-A) and La(SS-B) autoantibodies in relation to congenital heart block. Br J Rheum. 1988;27:128–132
  43. Scott JS, Taylor PV. Congenital atrioventricular-block: role of anti-Ro and anti-La antibodies. Springer Semin Immunopathol. 1989;11:397–408[Web of Science][Medline]
  44. Buyon JP, Ben-Chetrit E, Karp S. Acquired congenital heart block: pattern of maternal antibody response to biochemically defined antigens of the SSA/Ro-SSB/La system in neonatal lupus. J Clin Invest. 1989;84:627–634[Web of Science][Medline]
  45. Julkunen H, Kurki P, Kaaja R. Isolated congenital heart block. Long-term outcome of mothers and characterization of the immune response to SS-A/Ro and to SS-B/La. Arthritis Rheum. 1993;36:1588–1598[Web of Science][Medline]
  46. Borenstein DG, Fye WB, Arnett FC, Stevens MB. The myocarditis of systemic lupus erythematosus: association with myositis. Ann Intern Med. 1978;89:619–624[CrossRef][Web of Science][Medline]
  47. Fu ML. Anti-peptide antibodies against an autoimmune epitope on human muscarinic receptor mimic functional autoantibodies against the same epitope in patients with idiopathic dilated cardiomyopathy. Eur Heart J. 1995;16:89–91
  48. Fu ML, Gerd W, Ake H, Johan H. Agonist-like activity of anti-peptide antibodies directed against an autoimmune epitope on the heart muscarinic acetylcholine receptor. Receptor Channels. 1994;2:121–130[Web of Science][Medline]
  49. Helander E. Studies of the chemical components of the conducting system of the heart. II. The water soluble proteins. Cardiologia. 1965;47:146–153
  50. Szabo ST, Laohos E, Lukacs E, Kapusi A, Reichel C. Immunological properties of heart conducting system. Z Immunitaetsforsch Exp Ther. 1966;130:252–259
  51. Maisch B, Lotze U, Schneider J, Kochsiek K. Antibodies to human atrioventricular node and conducting tissue in atrioventricular block. Santini M, Pistolese M, Alliegro A. Progress in clinical pacing. Rome: CEPI-Verlag; 1988. p. 163–171
  52. Maisch B. The sarcolemma as antigen in the secondary immunopathogenesis of myopericarditis. Eur Heart J. 1987;8:155–158
  53. Obbiassi M, Brucato A, Meroni PL. Antibodies to cardiac Purkinje cells: Further characterization in autoimmune diseases and atrioventricular heart block. Clin Immunol Immunopathol. 1987;42:141–150[CrossRef][Web of Science][Medline]
  54. Ferrer J. The sick sinus syndrome. Circulation. 1973;47:635–644[Abstract/Free Full Text]
  55. Alboni P, Baggioni GF, Scarfo S. Role of sinus node artery disease in sick sinus syndrome in inferior wall acute myocardial infarction. Am J Cardiol. 1991;67:1180–1186[CrossRef][Web of Science][Medline]
  56. Heinz G, Kratochwill C, Schmid S. Sinus node dysfunction after orthotopic heart transplantation: the Vienna experience 1987–1993. Pacing Clin Electrophysiol. 1994;17:2057–2063[CrossRef][Medline]
  57. Heinz G, Kratochwill C, Koller-Strametz J. Benign prognosis of early sinus node dysfunction after orthotopic cardiac transplantation. Pacing Clin Electrophysiol. 1998;21:422–429[CrossRef][Medline]
  58. Calzolari V, Angelini A, Basso C, Livi U, Rossi L, Thiene G. Histologic findings in the conduction system after cardiac transplantation and correlation with electrocardiographic findings. Am J Cardiol. 1999;84:756–759[CrossRef][Web of Science][Medline]
  59. Ho SY, Esscher E, Anderson RH, Michaelsson M. Anatomy of congenital complete heart block and relation to maternal anti-Ro antibodies. Am J Cardiol. 1986;58:291–294[CrossRef][Web of Science][Medline]
  60. Anderson RH, Wenick ACG, Losekoot TG, Becker AE. Congenitally complete heart block. Circulation. 1977;56:90–98[Abstract/Free Full Text]
  61. Michaelsson M. Congenital complete atrioventricular block. Progr Pediatr Cardiol. 1995;4:1–7
  62. Buyon JP. Neonatal lupus: bedside to bench and back. Scand J Rheumatol. 1996;25:271–276[Web of Science][Medline]
  63. Buyon JP, Hiebert R, Copel J. Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol. 1998;31:1658–1666[Abstract/Free Full Text]
  64. Buyon JP, Waltuck J, Caldwell K. Relationship between maternal and neonatal levels of antibodies to 48kDa SSB(La), 52kDa SSA(Ro), and 60kDa SSA(Ro) in pregnancies complicated by congenital heart block. J Rheumatol. 1994;21:1943–1950[Web of Science][Medline]
  65. Buyon JP, Winchester RJ, Slade SC. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. Arthritis Rheum. 1993;36:1263–1273[Web of Science][Medline]
  66. Waltuck J, Buyon JP. Autoantibody-associated congenital heart block: outcome in mothers and children. Annals Int Med. 1994;120:544–551[Abstract/Free Full Text]
  67. Press J, Uziel Y, Laxer RM, Luy L, Hamilton RM. Long-term outcome of mothers of children with complete congenital heart block. Am J Med. 1996;100:328–332[CrossRef][Web of Science][Medline]
  68. Julkunen H, Kaaja R, Siren MK. Immune-mediated congenital heart block (CHB): identifying and counselling patients at risk for having children with CHB. Semin Arthritis Rheum. 1998;28:97–106[CrossRef][Web of Science][Medline]
  69. Siren MK, Julkunen H, Kaaja R, Ekblad H, Koskimies S. Role of HLA in congenital heart block: susceptibility alleles in children. Lupus. 1999;8:60–67[Abstract/Free Full Text]
  70. Roberts WC, Bulkley BH. The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy: A study of 36 necropsy patients. Am J Med. 1975;58:243–255[CrossRef][Web of Science][Medline]
  71. Bidani AK, Roberts JL, Schwartz MM, Lewis EJ. Immunopathology of cardiac lesions in fatal systemic lupus erythematosus. Am J Med. 1980;69:849–859[Web of Science][Medline]
  72. O'Neill TW, Mahmoud A, Tooke A, Thomas RD, Maddison PJ. Is there a relationship between subclinical myocardial abnormalities, conduction defects and Ro/La antibodies in adults with systemic lupus erythematosus? Clin Exp Rheumatol. 1993;11:409–412[Web of Science][Medline]
  73. Logar D, Kveder T, Rozman B, Dobovisek J. Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus. Ann Rheum Dis. 1990;49:627–629[Abstract/Free Full Text]
  74. Anuari A, Graninger W, Schneider B. Cardiac involvement in systemic sclerosis. Arthritis Rheum. 1992;35:1356–1364[Web of Science][Medline]
  75. D'Angelo WA, Fries JF, Masi AT, Shulman LE. Pathologic observations in systemic sclerosis: A study of 58 autopsy cases and 58 matched controls. Am J Med. 1969;46:428–433[CrossRef][Web of Science][Medline]
  76. Bulkley BH, Rudolfi RL, Salyer WR, Hutchins GM. Myocardial lesions of progressive systemic sclerosis: A cause of cardiac dysfunction. Circulation. 1976;53:483–490[Abstract/Free Full Text]

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