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European Heart Journal 2002 23(16):1253-1266; doi:10.1053/euhj.2002.3320
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Working Group Report

Recommendations on the management of the asymptomatic patient with valvular heart disease

B. Iunga, C. Gohlke-Bärwolfb, P. Tornosc, C. Tribouilloyd, R. Halle, E. Butchartf and A. Vahaniana,f1

a Service de Cardiologie, Hôpital Bichat, Paris, France
b Herz-Zentrum, Bad Krozingen, Germany
c Servicio de Cardiologia, Hospital Vall d'Hebron, Barcelona, Spain
d Service de Cardiologie B, C.H.U. Hôpital Sud, Amiens, France
e Department of Cardiology, Hammersmith Hospital, London, U.K.
f University Hospital, Cardiff, Wales, U.K.

Received May 13, 2002; accepted May 22, 2002

Key Words: Valvular heart disease, aortic stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation.

f1 Correspondence: Alec Vahanian, Service de Cardiologie, Hôpital Bichat, 46 rue Henri-Huchard, 75018, Paris, France.

References

  1. Bonow RO, Carabello B, DeLeon AC. ACC/AHA Guidelines for the management of patients with valvular heart disease. J Am Coll Cardiol. 1998;32:1486–1588[Free Full Text]
  2. Prendergast B, Banning AP, Hall RJC. Valvular heart disease: recommendations for investigation and management. Summary of guidelines produced by a working group of the British Cardiac Society and the Research Unit of the Royal College of Physicians. J R College Physicians Lond. 1996;30:309–315[Web of Science][Medline]
  3. Classen M, Diekesmann R, Heimpel H. Rationelle Diagnostik und Therapie in der Innere Medizin. Ein Beitrag zur Qualitatssicherung in Klinik und Praxis. Munchen: Urban and Fischer; 1999.
  4. Azpitarte J, Alonsi A, Garcia Gallego F. Guias de practica clinica de la Sociedad Espanola de Cardiologia en valvulopatias. Rev Esp Cardiol. 2000;53:1209–1278[Web of Science][Medline]
  5. Dujardin K, Enriquez-Sarano M, Bailey K, Nishimura R, Seward J, Tajik A. Grading of mitral regurgitation by quantitative Doppler echocardiography—calibration by left ventricular angiography in routine clinical practice. Circulation. 1997;96:3409–3415[Abstract/Free Full Text]
  6. Tribouilloy CM, Shen W, Leborgne L, Trojette F, Rey J, Lesbre J. Comparative value of Doppler echocardiography and cardiac catheterization for management decision-making in patients with left sided valvular regurgitation. Eur Heart J. 1996;17:272–280[Abstract/Free Full Text]
  7. Vandervoort PM, Thomas JD. New approaches to quantitation of valvular regurgitation. Otto CM. The Practice of Clinical Echocardiography. Philadelphia: WB Saunders; 1997. p. 307–326
  8. Enriquez-Sarano M, Freeman WK, Tribouilloy CM. Functional anatomy of mitral regurgitation: accuracy and outcome implications of transesophageal echocardiography. J Am Coll Cardiol. 1999;34:1129–1136[Abstract/Free Full Text]
  9. Wilkins GT, Weyman AE, Abascal VM, Block PC, Palacios IF. Percutaneous balloon dilatation of the mitral valve: an analysis of echocardiographic variables related to outcome and the mechanism of dilatation. Br Heart J. 1988;60:299–308[Abstract/Free Full Text]
  10. Cormier B, Vahanian A, Michel PL. Evaluation par échographie bidimensionnelle et Doppler des résultats de la valvuloplastie mitrale percutanée. Arch Mal Coeur. 1989;82:185–191
  11. Daniel WG, Nellessen U, Schroder E. Left atrial spontaneous contrast in mitral valve disease: an indicator for an increased thrombo-embolic risk. J Am Coll Cardiol. 1988;1:1204–1211
  12. Underwood MJ, El Khoury G, Deronk D. The aortic root: structure, function, and surgical reconstruction. Heart. 2000;83:376–380[Free Full Text]
  13. Gibbons RJ, Beasley JW, Bricker JT. ACC/AHA Guidelines for exercise testing: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Exercise Testing). J Am Coll Cardiol. 1997;30:260–311[CrossRef][Web of Science][Medline]
  14. Areskog NH. Exercise testing in the evaluation of patients with valvular aortic stenosis. Clin Physiol. 1984;4:201–208[Web of Science][Medline]
  15. Linderholm H, Osterman G, Teien D. Detection of coronary artery disease by means of exercise ECG in patients with aortic stenosis. Acta Med Scand. 1985;218:181–188[Web of Science][Medline]
  16. Clyne CA, Arrighi JA, Maron BJ, Bonow RO, Cannon RO. Systemic and left ventricular responses to exercise stress of asymptomatic patients with valvular aortic stenosis. Am J Cardiol. 1991;68:1469–1476[CrossRef][Web of Science][Medline]
  17. Otto CM, Pearlmann AS, Kraft CD, Miyake-Hull CY, Burwash IG, Gardner CJ. Physiological changes with maximal exercise in asymptomatic valvular aortic stenosis assessed by Doppler echocardiography. J Am Coll Cardiol. 1992;20:1160–1167[Abstract]
  18. Otto CM, Burwash IG, Legget ME. Prospective study of asymptomatic valvular aortic stenosis: clinical, echocardiographic and exercise predictors of outcome. Circulation. 1997;95:2262–2270[Abstract/Free Full Text]
  19. Amato MC, Moffa PJ, Werner KE, Ramires JA. Treatment decision in asymptomatic aortic valve stenosis: role of exercise testing. Heart. 2001;86:381–386[Abstract/Free Full Text]
  20. Hecker SL, Zabalgoitia M, Ashline P, Oneschuk L, O'Rourke RA, Herrera CJ. Comparison of exercise and dobutamine stress echocardiography in assessing mitral stenosis. Am J Cardiol. 1997;80:1374–1377[CrossRef][Web of Science][Medline]
  21. Dahan M, Paillole C, Martin D, Gourgon R. Determinants of stroke volume response to exercise in patients with mitral stenosis: a Doppler echocardiographic study. J Am Coll Cardiol. 1993;21:384–389[Abstract]
  22. Ambrosi P, Faugere G, Desfossez L. Assessment of aortic regurgitation severity by magnetic resonance imaging of the thoracic aorta. Eur Heart J. 1995;16:406–409[Abstract/Free Full Text]
  23. Ramsdale DR, Arumugan N, Singh SS, Pearson J, Charles RG. Holter monitoring in patients with mitral stenosis and sinus rhythm. Eur Heart J. 1997;8:164–170
  24. Dajani AS, Taubert KA, Wilson W. Prevention of bacterial endocarditis: recommendations by the American Heart Association. Circulation. 1997;96:358–366[Abstract/Free Full Text]
  25. Nylander E, Ekman I, Marklund T, Sinnerstad B, Karlsson E, Wranne B. Severe aortic stenosis in elderly patients. Br Heart J. 1986;55:480–487[Abstract/Free Full Text]
  26. Aronow WS, Kronzon I. Prevalence and severity of valvular aortic stenosis determined by Doppler echocardiography and its association with echocardiographic and electrocardiographic left ventricular hypertrophy and physical signs of aortic stenosis in elderly patients. Am J Cardiol. 1991;67:776–777[CrossRef][Web of Science][Medline]
  27. Lindroos M, Kupari M, Heikkila J, Tilvis R. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol. 1993;21:1220–1225[Abstract]
  28. Lorz W, Cottier C, Gyr N. The prevalence of aortic stenosis in an elderly population: an echocardiographic study in a small Swiss community. Cardiology in the Elderly. 1993;1:511–515
  29. Wagner S, Selzer A. Patterns of progression of aortic stenosis: a longitudinal hemodynamic study. Circulation. 1982;65:709–712[Free Full Text]
  30. Peter M, Hoffmann A, Parker C, Luscher T, Burckhardt D. Progression of aortic stenosis in adults: role of age and concomitant coronary artery disease. Chest. 1993;103:1715–1719[Abstract/Free Full Text]
  31. Iivanainen AM, Lindroos M, Tilvis R, Heikkila J, Kupari M. Natural history of aortic valve stenosis of varying severity in the elderly. Am J Cardiol. 1996;78:97–101[CrossRef][Web of Science][Medline]
  32. Ross J Jr, Braunwald E. Aortic stenosis. Circulation. 1968;38:61–67
  33. Turina J, Hess O, Sepulcri F, Krayenbuehl HP. Spontaneous course of aortic valve disease. Eur Heart J. 1987;8:471–483[Abstract/Free Full Text]
  34. Horstkotte D, Loogen F. The natural history of aortic valve stenosis. Eur Heart J. 1988;9:57–64
  35. Chizner MA, Pearle DL, deLeon AC Jr. The natural history or aortic stenosis in adults. Am Heart J. 1980;99:419–424[CrossRef][Web of Science][Medline]
  36. Kelly TA, Rothbart RM, Cooper CM, Kaiser DL, Smucker ML, Gibson RS. Comparison of outcome of asymptomatic to symptomatic patients older that 20 years of age with valvular aortic stenosis. Am J Cardiol. 1988;61:123–130[CrossRef][Web of Science][Medline]
  37. Pellikka PA, Nishimura RA, Bailey KR, Tajik AJ. The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis. J Am Coll Cardiol. 1990;15:1012–1017[Abstract]
  38. Kennedy KD, Nishimura RA, Bailey KR, Tajik AJ. The natural history of moderate aortic stenosis. J Am Coll Cardiol. 1991;17:313–319[Abstract]
  39. Faggiano P, Ghizzoni G, Sorgato A. Rate of progression of valvular aortic stenosis in adults. Am J Cardiol. 1992;70:229–233[CrossRef][Web of Science][Medline]
  40. Rosenhek R, Binder T, Porenta G. Predictors of outcome in severe asymptomatic aortic stenosis. N Engl J Med. 2000;343:611–617[Abstract/Free Full Text]
  41. Stewart BF, Siscovick D, Lind BK. Clinical factors associated with calcific aortic valve disease. J Am Coll Cardiol. 1997;29:630–634[Abstract]
  42. Lund O. Preoperative risk evaluation and stratification of long-term survival after valve replacement for aortic stenosis. Reasons for earlier operative intervention. Circulation. 1990;82:124–139[Abstract/Free Full Text]
  43. STS national database: STS US cardiac surgery database: 1997 aortic valve replacement patients; preoperative risk variables, Chicago Society of Cardiac Surgeons, 2000
  44. Kvidal P, Bergström R, Hörte L-G, Stahle E. Observed and relative survival after aortic valve replacement. J Am Coll Cardiol. 2000;35:747–756[Abstract/Free Full Text]
  45. Rahimtoola SH. Perspective on valvular heart disease: An update; ACC Anniversary Seminar. J Am Coll Cardiol. 1989;14:1–23[Web of Science][Medline]
  46. Eagle KA, Berger PB, Balkins H. ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation. 2002;105:1257–1267[Free Full Text]
  47. Marcovina SM, Kuusisto J, Alpers CB, Otto CM. Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of degenerative valvular aortic stenosis. Arterioscler Thromb Vasc Biol. 1996;16:523–532[Abstract/Free Full Text]
  48. Olsson M, Thyberg J, Nilsson J. Presence of oxidized low density lipoprotein in nonrheumatic stenosis aortic valves. Arterioscler Thromb Vasc Biol. 1999;19:1218–1222[Abstract/Free Full Text]
  49. Spagnuolo M, Kloth H, Taranta A, Doyle E, Pasternack B. Natural history of rheumatic aortic regurgitation: criteria predictive of death, congestive heart failure and angina in young patients. Circulation. 1971;44:368–372[Abstract/Free Full Text]
  50. Rapaport E. Natural history of aortic and mitral disease. Am J Cardiol. 1975;35:221–229[CrossRef][Web of Science][Medline]
  51. Bonow RO, Rosing DR, McIntosh ChL. The natural history of asymptomatic patients with aortic regurgitation and normal left ventricular function. Circulation. 1983;68:509–517[Free Full Text]
  52. Scognamiglio R, Fasoli G, Dalla Volta S. Progression of myocardial dysfunction in asymptomatic patients with severe aortic insufficiency. Clin Cardiol. 1986;9:151–156[Web of Science][Medline]
  53. Siemienczuk D, Greenberg B, Morris C. Chronic aortic insufficiency: factors associated with progression to aortic valve replacement. Ann Intern Med. 1989;110:587–592[Abstract/Free Full Text]
  54. Bonow RO, Lakatos E, Maron BJ, Epstein SE. Serial long term assessment of the natural history of asymptomatic patients with chronic aortic regurgitation and normal left ventricular systolic function. Circulation. 1991;84:1625–1635[Abstract/Free Full Text]
  55. Tornos MP, Olona M, Permanyer-Miralda G. Clinical outcome of severe asymptomatic chronic aortic regurgitation: a long-term prospective follow-up study. Am Heart J. 1995;130:333–339[CrossRef][Web of Science][Medline]
  56. Ishii K, Hirota Y, Suwa M, Kita Y, Onaka H, Kanamura K. Natural history and left ventricular response in chronic aortic regurgitation. Am J Cardiol. 1996;78:357–361[CrossRef][Web of Science][Medline]
  57. Borer JS, Hochreiter C, Herrold EM. Prediction of indications for valve replacement among asymptomatic or minimally symptomatic patients with chronic aortic regurgitation and normal left ventricular performance. Circulation. 1998;97:525–534[Abstract/Free Full Text]
  58. Tornos MP, Olona M, Permayer-Miralda G. Heart failure after aortic valve replacement for aortic regurgitation: prospective 20-year study. Am Heart J. 1998;136:681–687[CrossRef][Web of Science][Medline]
  59. Gaasch WH, Carroll JD, Levine HJ, Criscitiello MG. Chronic aortic regurgitation: prognostic value of left ventricular end-systolic dimension and end-diastolic radius/thickness ratio. J Am Coll Cardiol. 1983;1:775–782[Abstract]
  60. Klodas E, Enriquez-Sarano M, Tajik AJ, Mullany ChL, Bailey KR, Seward JB. Optimizing timing of surgical correction in patients with severe aortic regurgitation: role of symptoms. J Am Coll Cardiol. 1997;30:746–752[Abstract]
  61. Shores J, Berger KR, Murphy EA, Pyeritz RE. Progression of aortic dilatation and the benefit of long-term ß-adrenergic blockade in Marfan syndrome. N Engl J Med. 1994;330:1335–1341[Abstract/Free Full Text]
  62. Roman RJ, Rosen SE, Kramer-Fox R. Prognostic significance of the pattern of aortic root dilation in the Marfan syndrome. J Am Coll Cardiol. 1993;22:1470–1476[Abstract]
  63. Legget ME, Unger TA, O'Sullivan CK. Aortic root complications in Marfan syndrome: identification of a lower risk group. Heart. 1996;75:389–395[Abstract/Free Full Text]
  64. Sliverman DI, Gray J, Roman M. Family history of severe cardiovascular disease in Marfan syndrome is associated with increased aortic diameter and decreased survival. J Am Coll Cardiol. 1995;26:1062–1067[Abstract]
  65. Marsalese DL, Moodie DS, Lytle BS. Cystic medical necrosis of the aorta in patients without Marfan syndrome: surgical outcome and long-term follow-up. J Am Coll Cardiol. 1990;16:68–73[Abstract]
  66. Keane MG, Wiegers SE, Plappert T. Bicuspid aortic valves are associated with aortic dilatation out of proportion to coexistent valvular lesions. Circulation. 2000;102:III35–39
  67. Bonow RO, Picone AL, McIntosh CL. Survival and functional results after valve replacement for aortic regurgitation from 1976 to 1983: impact of preoperative left ventricular function. Circulation. 1985;72:1244–1256[Abstract/Free Full Text]
  68. Dujardin K, Enriquez-Sarano M, Schaff HV, Bailey KR, Seward JB, Tajik AJ. Mortality and morbidity of aortic regurgitation in clinical practice. A long-term follow-up study. Circulation. 1999;99:1851–1857[Abstract/Free Full Text]
  69. Henry WL, Bonow RO, Borer JS. Observations on the optimum time for operative intervention for aortic regurgitation: Evaluation of the results of aortic valve replacement in symptomatic patients. Circulation. 1980;61:471–483[Abstract/Free Full Text]
  70. Klodas E, Enriquez-Sarano M, Tajik AJ, Mullany CJ, Bailey KR, Seward JB. Surgery for aortic regurgitation in women. Contrasting indications and outcomes compared with men. Circulation. 1996;94:2472–2478[Abstract/Free Full Text]
  71. Treasure T. Cardiovascular surgery for Marfan syndrome. Heart. 2000;84:674–678[Free Full Text]
  72. Gott VL, Greene PS, Alejo DE. Replacement of the aortic root in patients with Marfan Syndrome. N Engl J Med. 1999;340:1307–1313[Abstract/Free Full Text]
  73. Birks EJ, Webb C, Child A, Radley-Smith R, Yacoub MH. Early and long-term results of a valve-sparing operation for Marfan syndrome. Circulation. 1999;100:II-29–35
  74. Rossiter JP, Repke JT, Morales AJ, Murphy EA, Pyeritz RE. A prospective longitudinal evaluation of pregnancy in the Marfan syndrome. Am J Obstet Gynecol. 1995;173:1599–1606[CrossRef][Web of Science][Medline]
  75. Greenberg B, Massie B, Bristow JD. Long-term vasodilator therapy of chronic aortic insufficiency. A randomized double-blinded placebo controlled clinical trial. Circulation. 1988;78:92–103[Abstract/Free Full Text]
  76. Lin M, Chiang H, Lin S. Vasodilator therapy in chronic asymptomatic aortic regurgitation: enalapril versus hydralazine therapy. J Am Coll Cardiol. 1994;24:1046–1053[Abstract]
  77. Scognamiglio R, Rahimtoola SH, Fasoli G, Nistri S, Dalla Volta S. Nifedipine in asymptomatic patients with severe aortic regurgitation and normal left ventricular function. N Engl J Med. 1994;331:689–694[Abstract/Free Full Text]
  78. Shon HR, Dorn R, Barthel P, Shoming J. Effect of 12 months quinapril therapy in asymptomatic patients with chronic aortic regurgitation. J Heart Valve Dis. 1994;3:500–509[Medline]
  79. Dubin AA, March HW, Chon K, Selzer A. Longitudinal hemodynamic and clinical study of mitral stenosis. Circulation. 1971;44:381–389[Abstract/Free Full Text]
  80. Gordon SP, Douglas PS, Come PC, Manning WJ. Two-dimensional and Doppler echocardiographic determinants of the natural history of mitral valve narrowing in patients with rheumatic mitral stenosis: implications for follow-up. J Am Coll Cardiol. 1992;19:968–973[Abstract]
  81. Rowe JC, Bland EF, Sprague HB, White PD. The course of mitral stenosis without surgery: ten- and twenty-year perspectives. Ann Intern Med. 1960;52:741–749[Abstract/Free Full Text]
  82. Bannister RG. The risk of deferring valvotomy in patients with moderate mitral stenosis. Lancet. 1960;2:329–333[CrossRef][Web of Science][Medline]
  83. Horstkotte D, Niehues R, Strauer BE. Pathomorphological aspects, aetiology and natural history of acquired mitral valve stenosis. Eur Heart J. 1991;12:55–60[Abstract/Free Full Text]
  84. Diker E, Aydogdu S, Ozdemir M. Prevalence and predictors of atrial fibrillation in rheumatic valvular heart disease. Am J Cardiol. 1997;77:96–98[Web of Science]
  85. Chiang CW, Lo SK, Ko YS, Cheng NJ, Lin PJ, Chang CH. Predictors of systemic embolism in patients with mitral stenosis. A prospective study. Ann Intern Med. 1998;128:885–889[Abstract/Free Full Text]
  86. Black DW, Hopkins AP, Lee LCL, Walsh WF, Jacobson BM. Left atrial spontaneous echo contrast: a clinical and echocardiographic analysis. J Am Coll Cardiol. 1991;18:398–404[Abstract]
  87. Marin F, Roldan V, Monmeneu JV. Prothrombotic state and elevated levels of plasminogen activator inhibitor-1 in mitral stenosis with and without atrial fibrillation. Am J Cardiol. 1999;84:962–964
  88. Arora R, Singh Kalra G, Ramachandra Murty GD. Percutaneous transatrial mitral commissurotomy: immediate and intermediate results. J Am Coll Cardiol. 1994;23:1327–1332[Abstract]
  89. Iung B, Cormier B, Ducimetière P. Immediate results of percutaneous mitral commissurotomy: a predictive model on a series of 1514 patients. Circulation. 1996;94:2124–2130[Abstract/Free Full Text]
  90. Circulation. 1992;85:2014–2024[Abstract/Free Full Text]
  91. Orrange SE, Kawanishi DT, Lopez BM, Curry SM, Rahimtoola SH. Actuarial outcome after catheter balloon commissurotomy in patients with mitral stenosis. Circulation. 1997;95:382–389[Abstract/Free Full Text]
  92. Chen CR, Cheng TO, Chen JY, Huang YG, Huang T, Zhang B. Long-term results of percutaneous balloon mitral valvuloplasty for mitral stenosis: a follow-up study to 11 years in 202 patients. Cathet Cardiovasc Diagn. 1998;43:132–139[CrossRef][Web of Science][Medline]
  93. Iung B, Garbarz E, Michaud P. Late results of percutaneous mitral commissurotomy in a series of 1024 patients: Analysis of late clinical deterioration: frequency, anatomical findings, and predictive factors. Circulation. 1999;99:3272–3278[Abstract/Free Full Text]
  94. Iung B, Garbarz E, Helou S. What are the results of percutaneous mitral commissurotomy in patients with few or no symptoms? (Abstr). Eur Heart J. 1998;19:529[Free Full Text]
  95. Cormier B, Vahanian A, Iung B. Influence of percutaneous mitral commissurotomy on left atrial spontaneous contrast of mitral stenosis. Am J Cardiol. 1993;71:842–847[CrossRef][Web of Science][Medline]
  96. Stefanadis C, Dernellis J, Stratos C. Effects of balloon mitral valvuloplasty on left atrial function in mitral stenosis as assessed by pressure-area relation. J Am Coll Cardiol. 1998;32:159–168[Abstract/Free Full Text]
  97. Yamamoto K, Ikeda U, Minezaki KK. Effect of mitral valvuloplasty in mitral stenosis on coagulation activity. Am J Cardiol. 1997;79:1131–1134[CrossRef][Web of Science][Medline]
  98. Fuster V, Rydén L, Asinger. ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: executive summary: A Report by the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients with Atrial Fibrillation) Developed in Collaboration with the North American Society of Pacing and Electrophysiology. J Am Coll Cardiol. 2001;38:1231–1265[Free Full Text]
  99. Gohlke-Bärwolf C, Acar J, Oakley C. Guidelines for prevention of thromboembolic events in valvular heart disease. Study group of the Working Group on valvular heart disease of the European Society of Cardiology. Eur Heart J. 1995;16:1320–1330[Free Full Text]
  100. Delahaye J, Gare J, Viguier E, Delahaye F, De Gevigney G, Milon H. Natural history of severe mitral regurgitation. Eur Heart J. 1991;12:5–9
  101. Horstkotte D, Loogen F, Kleikamp G, Schulte HD, Trampisch HJ, Bircks W. The influence of heart valve replacement on the natural history of isolated mitral, aortic and multivalvular disease. Z Kardiol. 1983;72:494–503[Web of Science][Medline]
  102. Ling H, Enriquez-Sarano M, Seward J. Clinical outcome of mitral regurgitation due to flail leaflets. N Engl J Med. 1996;335:1417–1423[Abstract/Free Full Text]
  103. Grigioni F, Enriquez-Sarano M, Ling L. Sudden death in mitral regurgitation due to flail leaflet. J Am Coll Cardiol. 1999;34:2078–2085[Abstract/Free Full Text]
  104. Perier P, Deloche A, Chauvaud S. Comparative evaluation of mitral valve repair and replacement with Starr, Bjork, and porcine valve prostheses. Circulation. 1984;70:I187–192
  105. Acar J, Michel P, Luxereau P, Vahanian A, Cormier B. Indications for surgery in mitral regurgitation. Eur Heart J. 1991;12:52–54
  106. Gaasch W, John R, Aurigemma G. Managing asymptomatic patients with chronic mitral regurgitation. Chest. 1995;108:842–847[Free Full Text]
  107. Lee EM, Shapiro LM, Wells FC. Superiority of mitral valve repair in surgery for degenerative mitral regurgitation. Eur Heart J. 1997;18:655–663[Abstract/Free Full Text]
  108. Enriquez-Sarano M, Orszulak T, Schaff H, Abel M, Tajik A, Frye R. Mitral regurgitation: a new clinical perspective. Mayo Clin Proc. 1997;72:1034–1043[Abstract]
  109. Schlant RC. Timing of surgery for patients with nonischemic severe mitral regurgitation. Circulation. 1999;99:338–339[Free Full Text]
  110. Braunberger E, Deloche A, Berrebi A. Very long-term results (more than 20 years) of valve repair with Carpentier's techniques in non rheumatic mitral valve insufficiency. Circulation. 2001;104:I8–11
  111. Tribouilloy CM, Enriquez-Sarano M, Schaff HV. Impact of preoperative symptoms on survival after surgical correction of organic mitral regurgitation: Rationale for optimizing surgical indications. Circulation. 1999;99:400–405[Abstract/Free Full Text]
  112. Sousa Uva M, Dreyfus G, Rescigno G. Surgical treatment of asymptomatic and mildly symptomatic mitral regurgitation. J Thorac Cardiovasc Surg. 1996;112:1240–1248[Abstract/Free Full Text]
  113. Garbarz E, Barabas M, Iung B. What are the long-term results in the 90s of valve repair in patients who have severe flail leaflet and few symptoms? (Abstr). Eur Heart J. 1998;19:357
  114. Reed D, Abbott R, Smucker M, Kaul S. Prediction of outcome after mitral valve replacement in patients with symptomatic chronic mitral regurgitation. The importance of left atrial size. Circulation. 1991;84:23–34[Abstract/Free Full Text]
  115. Enriquez-Sarano M, Tajik A, Schaff H, Orszulak T, Bailey K, Frye R. Echocardiographic prediction of survival after surgical correction of organic mitral regurgitation. Circulation. 1994;90:830–837[Abstract/Free Full Text]
  116. Enriquez-Sarano M, Tajik A, Schaff H. Echocardiographic prediction of left ventricular function after correction of mitral regurgitation: Results and clinical implications. J Am Coll Cardiol. 1994;24:1536–1543[Abstract]
  117. Zile MR, Gaasch WH, Carroll JD, Chan MR. Predictive value of pre-operative echographic indexes of left ventricular function and wall stress. J Am Coll Cardiol. 1984;3:235–242[Abstract]
  118. Wisenbaugh T, Skudicky D, Sareli P. Prediction of outcome after valve replacement for rheumatic mitral regurgitation in the era of chordal preservation. Circulation. 1994;89:191–197[Abstract/Free Full Text]
  119. Crawford M, Souchek J, Oprian C. Determinants of survival and left ventricular performance after mitral valve replacement. Circulation. 1990;81:1173–1181[Abstract/Free Full Text]
  120. Mohty D, Orszulak TA, Schaff HV, Avierinos JF, Tajik JA, Enriquez-Sarano M. Very long-term survival and durability of mitral valve repair for mitral valve prolapse. Circulation. 2001;104:I-1–17
  121. Duran CM, Gometza B, de vol EB. Valve repair in rheumatic mitral disease. Circulation. 1991;84:III-125–32
  122. Chauvaud S, Fuzellier JF, Berrebi A, Deloche A, Fabiani JN, Carpentier A. Long-term results of reconstructive surgery in rheumatic mitral valve insufficiency. Circulation. 2001;Suppl I:I12–15
  123. Levine HJ, Gaasch WH. Vasoactive drugs in chronic regurgitant lesions of the mitral and aortic valves. J Am Coll Cardiol. 1996;28:1083–1091[Abstract]
  124. Kelback H, Aldershvile J, Skagen K. Pre-and afterload reduction in chronic mitral regurgitation:a double blind randomised placebo-controlled trial of the acute and 2 weeks effect of nifedipine or isosorbide dinitrate treatment on the left ventricular function and the severity of mitral regurgitation. Br J Clin Pharmacol. 1996;41:493–497[CrossRef][Web of Science][Medline]
  125. Wisenbaugh T, Sinovich V, Dullabh A, Sareli P. Six-month pilot study of Captopril for mildly symptomatic, severe isolated mitral and isolated aortic regurgitation. J Heart Valve Dis. 1994;3:197–204[Medline]

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Circulation, July 7, 2009; 120(1): 69 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
P. Lancellotti, D. Karsera, G. Tumminello, F. Lebois, and L. A. Pierard
Determinants of an abnormal response to exercise in patients with asymptomatic valvular aortic stenosis
Eur J Echocardiogr, May 1, 2008; 9(3): 338 - 343.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
A. J. Mittnacht, M. Fanshawe, and S. Konstadt
Anesthetic Considerations in the Patient With Valvular Heart Disease Undergoing Noncardiac Surgery
Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2008; 12(1): 33 - 59.
[Abstract] [PDF]

Home page
 HeartHome page
L. A Pierard and P. Lancellotti
Stress testing in valve disease
Heart, June 1, 2007; 93(6): 766 - 772.
[Full Text] [PDF]

Home page
 HeartHome page
N. C Van Pelt, R. A H Stewart, M. E Legget, G. A Whalley, S. P Wong, I. Zeng, M. Oldfield, and A. J Kerr
Longitudinal left ventricular contractile dysfunction after exercise in aortic stenosis
Heart, June 1, 2007; 93(6): 732 - 738.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. A. Yousefnia, M. H. Mandegar, F. Roshanali, F. Alaeddini, and F. Amouzadeh
Papillary Muscle Repositioning in Mitral Valve Replacement in Patients With Left Ventricular Dysfunction
Ann. Thorac. Surg., March 1, 2007; 83(3): 958 - 963.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Authors/Task Force Members, A. Vahanian, H. Baumgartner, J. Bax, E. Butchart, R. Dion, G. Filippatos, F. Flachskampf, R. Hall, B. Iung, et al.
Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
Eur. Heart J., January 26, 2007; (2007) ehl428v1.
[Full Text] [PDF]

Home page
 HeartHome page
G. Maurer
Aortic regurgitation.
Heart, July 1, 2006; 92(7): 994 - 1000.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
E. G. Butchart, C. Gohlke-Barwolf, M. J. Antunes, P. Tornos, R. De Caterina, B. Cormier, B. Prendergast, B. Iung, H. Bjornstad, C. Leport, et al.
Recommendations for the management of patients after heart valve surgery
Eur. Heart J., November 2, 2005; 26(22): 2463 - 2471.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
J-L Monin
Stress haemodynamics for asymptomatic mitral regurgitation: how much does it help?
Heart, November 1, 2005; 91(11): 1383 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
H. Baumgartner
Aortic stenosis: medical and surgical management
Heart, November 1, 2005; 91(11): 1483 - 1488.
[Full Text] [PDF]

Home page
 HeartHome page
H Baumgartner
What influences the outcome of valve replacement in critical aortic stenosis?
Heart, October 1, 2005; 91(10): 1254 - 1256.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. Evangelista, P. Tornos, A. Sambola, G. Permanyer-Miralda, and J. Soler-Soler
Long-term vasodilator therapy in patients with severe aortic regurgitation.
N. Engl. J. Med., September 29, 2005; 353(13): 1342 - 1349.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J.-L. Monin, P. Dehant, C. Roiron, M. Monchi, J.-Y. Tabet, P. Clerc, G. Fernandez, R. Houel, J. Garot, C. Chauvel, et al.
Functional Assessment of Mitral Regurgitation by Transthoracic Echocardiography Using Standardized Imaging Planes: Diagnostic Accuracy and Outcome Implications
J. Am. Coll. Cardiol., July 19, 2005; 46(2): 302 - 309.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
H. Baumgartner
Management of asymptomatic aortic stenosis: how helpful is exercise testing?
Eur. Heart J., July 1, 2005; 26(13): 1252 - 1254.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. Scognamiglio, C. Negut, M. Palisi, G. Fasoli, and S. Dalla-Volta
Long-term survival and functional results after aortic valve replacement in asymptomatic patients with chronic severe aortic regurgitation and left ventricular dysfunction
J. Am. Coll. Cardiol., April 5, 2005; 45(7): 1025 - 1030.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
P. Lim, J. L. Monin, M. Monchi, J. Garot, A. Pasquet, L. Hittinger, J. L. Vanoverschelde, A. Carayon, and P. Gueret
Predictors of outcome in patients with severe aortic stenosis and normal left ventricular function: role of B-type natriuretic peptide
Eur. Heart J., November 2, 2004; 25(22): 2048 - 2053.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. Enriquez-Sarano and A. J. Tajik
Aortic Regurgitation
N. Engl. J. Med., October 7, 2004; 351(15): 1539 - 1546.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. Hellgren, P. Kvidal, L.-G. Horte, U.-B. Krusemo, and E. Stahle
Survival After Mitral Valve Replacement: Rationale for Surgery Before Occurrence of Severe Symptoms
Ann. Thorac. Surg., October 1, 2004; 78(4): 1241 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Nakajima, J. Kobayashi, K. Bando, Y. Yasumura, S. Nakatani, K. Kimura, K. Niwaya, O. Tagusari, and S. Kitamura
Consequence of atrial fibrillation and the risk of embolism after percutaneous mitral commissurotomy: The necessity of the maze procedure
Ann. Thorac. Surg., September 1, 2004; 78(3): 800 - 805.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Bergler-Klein, U. Klaar, M. Heger, R. Rosenhek, G. Mundigler, H. Gabriel, T. Binder, R. Pacher, G. Maurer, and H. Baumgartner
Natriuretic Peptides Predict Symptom-Free Survival and Postoperative Outcome in Severe Aortic Stenosis
Circulation, May 18, 2004; 109(19): 2302 - 2308.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Vahanian and I. F. Palacios
Percutaneous Approaches to Valvular Disease
Circulation, April 6, 2004; 109(13): 1572 - 1579.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
B. Iung, A. Nicoud-Houel, O. Fondard, H. Akoudad, T. Haghighat, E. Brochet, E. Garbarz, B. Cormier, G. Baron, P. Luxereau, et al.
Temporal trends in percutaneous mitral commissurotomy over a 15-year period
Eur. Heart J., April 2, 2004; 25(8): 701 - 707.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
G. P McCann and W S. Hillis
Surgery in asymptomatic aortic stenosis
BMJ, January 10, 2004; 328(7431): 63 - 64.
[Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
O. Bech-Hanssen, T. Ryden, H. Schersten, A. Oden, F. Nilsson, and A. Jeppsson
Mortality after mitral regurgitation surgery: importance of clinical and echocardiographic variables
Eur. J. Cardiothorac. Surg., November 1, 2003; 24(5): 723 - 730.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
B. Iung, G. Baron, E. G. Butchart, F. Delahaye, C. Gohlke-Barwolf, O. W. Levang, P. Tornos, J.-L. Vanoverschelde, F. Vermeer, E. Boersma, et al.
A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease
Eur. Heart J., July 1, 2003; 24(13): 1231 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
P. Das, H. Rimington, N. Smeeton, and J. Chambers
Determinants of symptoms and exercise capacity in aortic stenosis: a comparison of resting haemodynamics and valve compliance during dobutamine stress
Eur. Heart J., July 1, 2003; 24(13): 1254 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
Y. Misawa, K. Fuse, H. P. Chaliki, D. Mohty, J.-F. Avierinos, A. J. Tajik, M. Enriquez-Sarano, C. G. Scott, and H. V. Schaff
Left Ventricular Remodeling After Valve Replacement in Patients With Isolated Aortic Regurgitation * Response
Circulation, June 10, 2003; 107 (22): e208 - e209.
[Full Text] [PDF]

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