Skip Navigation

European Heart Journal 2002 23(2):102-105; doi:10.1053/euhj.2001.2850
Copyright © 2002 by the European Society of Cardiology.
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Walker, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Walker, J. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Editorials

The heart in thalassaemia

J. M. Walker

Department of Cardiology, University College Hospital, London, U.K.

References

  1. Hill AV. Molecular epidemiology of the thalassaemias (including haemoglobin E). Baillieres Clinical Haematology. 1992;5:209–238[Web of Science][Medline]
  2. Weatherall DJ. Oxford Textbook of Medicine. Anaemia as a World Health Problem. Oxford: Oxford University Press; 2001. p. 3463–82
  3. Sephton-Smith R. Iron excretion in thalassaemia major after administration of chelating agents. Br Med J. 1962;ii:1577–1580
  4. Modell B, Khan M, Darlison M. Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet. 2000;355:2051–2052[CrossRef][Web of Science][Medline]
  5. Tenenbein M, Kopelow ML, deSa DJ. Myocardial failure and shock in iron poisoning. Hum Toxicol. 1988;7:281–284[Web of Science][Medline]
  6. Sanyal SK, Johnson W, Jayalakshmamma B, Green AA. Fatal ‘iron heart’ in an adolescent: biochemical and ultrastructural aspects of the heart. Pediatrics. 1975;55:336–341[Abstract/Free Full Text]
  7. Engle MA, Erlandson M, Smith CH. Late cardiac complications of chronic, severe, refractory anaemia with hemochromatosis. Circulation. 1964;30:689
  8. Bannerman RM, Keusch G, Kreimer-Birnbaum M, Vance VK, Vaughan S. Thalassemia intermedia, with iron overload, cardiac failure, diabetes mellitus, hypopituitarism and porphyrinuria. Am J Med. 1967;42:476–486[CrossRef][Web of Science][Medline]
  9. Zurlo MG, De Stefano P, Borna-Pignatti C. Survival and causes of death in thalassaemia major. Lancet. 1989;ii:27–30
  10. Buja LM, Roberts WC. Iron in the heart. Etiology and clinical significance. Am J Med. 1971;51:209–221[CrossRef][Web of Science][Medline]
  11. Fitchett DH, Coltart DJ, Littler WA. Cardiac involvement in secondary haemochromatosis: a catheter biopsy study and analysis of myocardium. Cardiovasc Res. 1980;14:719–724[Web of Science][Medline]
  12. Olson LJ, Edwards WD, McCall JT, Ilstrup DM, Gersh BJ. Cardiac iron deposition in idiopathic hemochromatosis: histologic and analytic assessment of 14 hearts from autopsy. J Am Coll Cardiol. 1987;10:1239–1243[Abstract]
  13. Rahko PS, Salerni R, Uretsky BF. Successful reversal by chelation therapy of congestive cardiomyopathy due to iron overload. J Am Coll Cardiol. 1986;8:436–440[Abstract]
  14. Freeman AP, Giles RW, Berdoukas VA, Talley PA, Murray IP. Sustained normalization of cardiac function by chelation therapy in thalassaemia major. Clin Lab Haematol. 1989;11:299–307[Web of Science][Medline]
  15. Wacker P, Halperin DS, Balmer-Ruedin D, Oberhansli I, Wyss M. Regression of cardiac insufficiency after ambulatory intravenous deferoxamine in thalassemia major. Chest. 1993;103:1276–1278[CrossRef][Web of Science][Medline]
  16. Hershko C, Koniju AM. Therapeutic potential of iron chelating drugs. Hematologia. 1999;3:67–71
  17. Di Gregorgio F, Leonardi C, Sciuto C, Cannella A, Pizzarelli G. Intensive intravenous chelation in thalassaemic patients with iron overload. Minerva Pediatrica. 1998;50:81–85[Medline]
  18. Wolfe L, Olivieri N, Sallan D. Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major. N Engl J Med. 1985;312:1600–1603[Abstract]
  19. Olivieri NF, Nathan DG, MacMillan JH. Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med. 1994;331:574–578[Abstract/Free Full Text]
  20. Telfer PT, Prestcott E, Holden S, Walker M, Hoffbrand AV, Wonke B. Hepatic iron concentration combined with long-term monitoring of serum ferritin to predict complications of iron overload in thalassaemia major. Br J Haematol. 2000;110:971–977[CrossRef][Web of Science][Medline]
  21. Adams ET, Schwartz KA. Iron-induced myocardial and hepatic lysosomal abnormalities in the guinea pig. Toxicol Pathol. 1993;21:321–326[Web of Science][Medline]
  22. Bartfay WJ, Dawood F, Wen WH. Cardiac function and cytotoxic aldehyde production in a murine model of chronic iron-overload. Cardiovasc Res. 1999;43:892–900[Abstract/Free Full Text]
  23. Bartfay WJ, Bartfay E. Iron-overload cardiomyopathy: evidence for a free radical-mediated mechanism of injury and dysfunction in a murine model. Biol Res Nurs. 2000;2:49–59[Abstract/Free Full Text]
  24. Carthew P, Dorman BM, Edwards RE, Francis JE, Smith AG. A unique rodent model for both the cardiotoxic and hepatotoxic effects of prolonged iron overload. Lab Invest. 1993;69:217–222[Web of Science][Medline]
  25. Liu P, Henkelman M, Joshi J. Quantification of cardiac and tissue iron by nuclear magnetic resonance relaxometry in a novel murine thalassemia-cardiac iron overload model. Can J Cardiol. 1996;12:155–164[Web of Science][Medline]
  26. Schwartz KA, Fisher J, Adams ET. Morphologic investigations of the guinea pig model of iron overload. Toxicol Pathol. 1993;21:311–320[Web of Science][Medline]
  27. Gabutti V, Piga A. Results of long-term iron-chelating therapy. Acta Haematologica. 1996;95:26–36[Web of Science][Medline]
  28. Chapman RW, Hussain MA, Gorman A, DM. Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload. J Clin Pathol. 1982;35:487–491[Abstract/Free Full Text]
  29. Brittenham GM, Cohen AR, McLaren CE. Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol. 1993;42:81–85[Web of Science][Medline]
  30. Overmoyer BA, McLaren CE, Brittenham GM. Uniformity of liver density and nonheme (storage) iron distribution. Archives Pathol Lab Med. 1987;111:549–554
  31. Johnston DL, Rice L, Vick GW III, Hedrick TD, Rokey R. Assessment of tissue iron overload by nuclear magnetic resonance imaging. Am J Med. 1989;87:40–47[Web of Science][Medline]
  32. Blankenberg F, Eisenberg S, Scheinman MN, Higgins CB. Use of cine gradient echo (GRE) MR in the imaging of cardiac hemochromatosis. J Comput Assist Tomogr. 1994;18:136–138[Web of Science][Medline]
  33. Mavrogeni SI, Maris T, Gouliamos A, Vlahos L, Kremastinos DT. Myocardial iron deposition in beta-thalassemia studied by magnetic resonance imaging. Int J Card Imaging. 1998;14:117–122[CrossRef][Web of Science][Medline]
  34. Mavrogeni SI, Gotsis ED, Markussis V. T2 relaxation time study of iron overload in ß-thalassemia. MAGMA. 1998;6:7–12[Medline]
  35. Ooi GC, Chen FE, Chan KN. Qualitative and quantitative magnetic resonance imaging in haemoglobin H disease: screening for iron overload. Clin Radiol. 1999;54:98–102[CrossRef][Web of Science][Medline]
  36. Papanikolaou N, Ghiatas A, Kattamis A, Ladis C, Kritikos N, Kattamis C. Non-invasive myocardial iron assessment in thalassaemic patients. T2 relaxometry and magnetization transfer ratio measurements. Acta Radiol. 2000;41:348–351[CrossRef][Web of Science][Medline]
  37. Ernst O, Calvo M, Sergent G, Mizrahi D, Carpentier F. Breath-hold MR cholangiopancreatography using a HASTE sequence: comparison of single-slice and multislice acquisition techniques. Am J Roentgenol. 1997;169:1304–1306[Free Full Text]
  38. Anderson L, Holden S, Davis B. Early diagnosis of myocardial iron overload in thalassaemia major using T2* cardiovascular magnetic resonance. J Am Coll Cardiol. 2001;:
  39. Aldouri MA, Wonke B, Hoffbrand AV. High incidence of cardiomyopathy in beta-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation. Acta Haematol. 1990;84:113–117[Web of Science][Medline]
  40. Leon MB, Borer JS, Bacharach SL. Detection of early cardiac dysfunction in patients with severe beta-thalassemia and chronic iron overload. N Engl J Med. 1979;301:1143–1148[Abstract]
  41. Henry WL, Nienhuis AW, Wiener M, Miller DR, Canale VC, Piomelli S. Echocardiographic abnormalities in patients with transfusion-dependent anemia and secondary myocardial iron deposition. Am J Med. 1978;64:547–555[CrossRef][Web of Science][Medline]
  42. Nienhuis AW, Griffith P, Strawczynski H. Evaluation of cardiac function in patients with thalassemia major. Ann NY Acad Sci. 1980;344:384–396[Medline]
  43. Yee H, Mra R, Nyunt KM. Cardiac abnormalities in the thalassaemia syndromes. Southeast Asian J Trop Med Public Health. 1984;15:414–421[Medline]
  44. Olson LJ, Baldus WP, Tajik AJ. Echocardiographic features of idiopathic hemochromatosis. Am J Cardiol. 1987;60:885–889[CrossRef][Web of Science][Medline]
  45. Cecchetti G, Binda A, Piperno A, Nador F, Fargion S, Fiorelli G. Cardiac alterations in 36 consecutive patients with idiopathic haemochromatosis: polygraphic and echocardiographic evaluation. Eur Heart J. 1991;12:224–230[Abstract/Free Full Text]
  46. Spirito P, Lupi G, Melevendi C, Vecchio C. Restrictive diastolic abnormalities identified by Doppler echocardiography in patients with thalassemia major. Circulation. 1990;82:88–94[Abstract/Free Full Text]
  47. Kremastinos DT, Tsiapras DP, Tsetsos GA, Rentoukas EI, Vretou HP, Toutouzas PK. Left ventricular diastolic Doppler characteristics in beta-thalassemia major. Circulation. 1993;88:1127–1135[Abstract/Free Full Text]
  48. Mariotti E, Agostini A, Angelucci E, Cesaroni P, Lucarelli G, Sgarbi E. Cardiac study by dobutamine stress echocardiography in thalassemic patients. Bone Marrow Transplant. 1993;12:14–15[Medline]
  49. Suarez WA, Snyder SA, Berman BB, Brittenham GM, Patel CR. Preclinical cardiac dysfunction in transfusion-dependent children and young adults detected with low-dose dobutamine stress echocardiography. J Am Soc Echocardiogr. 1998;11:948–956[CrossRef][Web of Science][Medline]
  50. Intragumtornchai T, Minaphinant K, Wanichsawat C. Echocardiographic features in patients with beta thalassemia/hemoglobin E: a combining effect of anemia and iron load. J Med Assoc Thailand. 1994;77:57–65[Medline]
  51. Lattanzi F, Bellotti P, Picano E. Quantitative ultrasonic analysis of myocardium in patients with thalassemia major and iron overload. Circulation. 1993;87:748–754[Abstract/Free Full Text]
  52. Kremastinos DT, Toutouzas PK, Vyssoulis GP, Venetis CA, Vretou HP, Avgoustakis DG. Global and segmental left ventricular function in beta-thalassemia. Cardiology. 1985;72:129–139[Web of Science][Medline]
  53. Kremastinos DT, Toutouzas PK, Vyssoulis GP, Venetis CA, Avgoustakis DG. Iron overload and left ventricular performance in beta thalassemia. Acta Cardiol. 1984;39:29–40[Web of Science][Medline]
  54. Kremastinos DT, Tiniakos G, Theodorakis GN, Katritsis DG, Toutouzas PK. Myocarditis in beta-thalassemia major. A cause of heart failure. Circulation. 1995;91:66–71[Abstract/Free Full Text]
  55. Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood. 1997;89:739–761[Free Full Text]
  56. Hahalis G, Manolis AS, Apostolopoulos D, Alexopoulos D, Vagenakis AG, Zoumbos N. Right ventricular cardiomyopathy in ß-thalassaemia major. Eur Heart J. 2002;23:147–156[Abstract/Free Full Text]
  57. Grisaru D, Rachmilewitz FA, Mosseri M. Cardiopulmonary assessment in ß-thalassaemia major. Chest. 1990;98:1138–1142[CrossRef][Web of Science][Medline]
  58. Koren A, Garty I, Antonelli D, Katzuni E. Right ventricular cardiac dysfunction in beta-thalassemia major. Am J Dis Child. 1987;141:93–96[Abstract/Free Full Text]
  59. Piatti G, Allegra L, Ambrosetti U, Cappellini MD, Turati F, Fiorelli G. Beta-thalassemia and pulmonary function. Haematologica. 1999;84:804–808[Abstract/Free Full Text]
  60. Tai DY, Wang YT, Lou J, Wang WY, Mak KH, Cheng HK. Lungs in thalassaemia major patients receiving regular transfusion. Eur Respir J. 1996;9:1389–1394[Abstract]
  61. Lesnefsky EJ, Allen KG, Carrea FP, Horwitz LD. Iron-catalyzed reactions cause lipid peroxidation in the intact heart. J Mol Cell Cardiol. 1992;24:1031–1038[CrossRef][Web of Science][Medline]
  62. Hershko C, Link G, Cabantchik I. Pathophysiology of iron overload. Ann NY Acad Sci. 1998;850:191–201[CrossRef][Web of Science][Medline]
  63. Lesnefsky EJ. Tissue iron overload and mechanisms of iron-catalyzed oxidative injury. Adv Exp Med Biol. 1994;366:129–146[Medline]
  64. Weatherall DJ. Single gene disorders or complex traits: lessons from the thalassaemias and other monogenic diseases. BMJ. 2000;321:1117–1120[Free Full Text]
  65. Weatherall DJ. Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nature Rev Gen. 2001;2:245–255[CrossRef][Web of Science][Medline]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?



This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Walker, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Walker, J. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?