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European Heart Journal 2002 23(2):124-132; doi:10.1053/euhj.2001.2707
Copyright © 2002 by the European Society of Cardiology.
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Predictors and outcomes of stent thrombosis. An intravascular ultrasound registry

N.G. Urenf1, S.P. Schwarzacher, J.A. Metz, D.P. Lee, Y. Honda, A.C. Yeung, P.J. Fitzgerald and P.G. Yock

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, U.S.A.

revised March 27, 2001; accepted March 28, 2001

Abstract

Aims To investigate whether intravascular ultrasound provides additional information regarding the prediction of stent thrombosis, a retrospective multicentre registry was designed to enrol patients with stent thrombosis following stent deployment under ultrasound guidance.

Methods and Results A total of 53 patients were enrolled (mean age 61±9 years) with stable angina (43%), unstable angina (36%), and post-infarct angina (21%) who underwent intracoronary stenting. The majority had balloon angioplasty alone prior to stenting (94%) with 6% also undergoing rotational atherectomy. The indication for stenting was elective (53%), suboptimal result (32%) and bailout (15%). There were 1·6±0·8 stents/artery with 87% undergoing high-pressure dilatation (≥14 atmospheres). The minimum stent area was 7·7±2·8mm2with a mean stent expansion of 81·5±21·9%. Overall, 94% of cases demonstrated one abnormal ultrasound finding (stent under-expansion, malapposition, inflow/outflow disease, dissection, or thrombus). Angiography demonstrated an abnormality in only 32% of cases (chi-square=30·0,P <0·001). Stent thrombosis occurred at 132±125h after deployment. Myocardial infarction occurred in 67% and there was an overall mortality of 15%.

Conclusion On comparison with angiography, the vast majority of stents associated with subsequent thrombosis have at least one abnormal feature by intravascular ultrasound at the time of stent deployment.

Key Words: Intravascular ultrasound, intracoronary stents, thrombosis

f1 Correspondence: Neal Uren MD MRCP FESC, Department of Cardiology, Royal Infirmary, 1 Lauriston Place, Edinburgh EH3 9YW, U.K.


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