Copyright © 2002 by the European Society of Cardiology.
Serological markers of Chlamydia pneumoniae infection in men and women and subsequent coronary events. The Scottish Heart Health Study Cohort
a Cardiovascular Epidemiology Unit, University of Dundee, Ninewells Hospital and Medical School, Dundee, U.K.
b Infection and Immunity, Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, U.K.
c Department of Cardiology, Ninewells Hospital and Medical School, Dundee, U.K.
revised April 24, 2001; accepted May 2, 2001
Abstract
Aims To investigate the relationship between serum markers of Chlamydia pneumoniae infection and subsequent coronary events.
Methods and Results In a nested case-control study, based on the Scottish Heart Health Study cohort, we estimated IgG, IgA and IgM antibodies to C. pneumoniae, and circulating immune complexes containing C. pneumoniae antigen in baseline serum samples from 217 cases experiencing a subsequent coronary event during follow-up (mean 7·5 years) and from their matched controls. In men, the proportion of specimens positive for IgG, IgA and IgM antibodies showed no case-control differences (80% vs 80%, 57% vs 53% and 3% vs 3%, respectively). The odds ratio for a coronary event was 1·00 (95% confidence interval 0·59–1·69) for the presence of IgG antibodies to C. pneumoniae; 1·21 (0·76–1·92) for IgA and 0·75 (0·17–3·35) for IgM. Similar results were seen in women. The proportion of specimens with circulating immune complexes with C. pneumoniae antigen also showed no case-control differences (12% vs 12%, both sexes combined) with an odds ratio of 1·00 (0·57–1·76).
Conclusion Prior infection with C. pneumoniae, as estimated by these markers, does not appear to be a risk factor for subsequent coronary heart disease.
Key Words: Coronary artery disease • Chlamydia pneumoniae infection • epidemiology • immune complexes
f1 Correspondence: Roger Tavendale, PhD, Cardiovascular Epidemiology Unit, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K.
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