Skip Navigation

European Heart Journal 2002 23(4):325-330; doi:10.1053/euhj.2001.2776
Copyright © 2002 by the European Society of Cardiology.
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow References
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Benze, G.
Right arrow Articles by Junker, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Benze, G.
Right arrow Articles by Junker, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men

G. Benzea, J. Heinrichb, H. Schultec, S. Rustc, U. Nowak-Göttld, M.-C. Tatarue, E. Köhlerf, G. Assmanna,c and R. Junkera,c,f1

a Institut für Klinische Chemie und Laboratoriumsmedizin, Westfälische Wilhelms-Universität Münster, Münster, Germany
b Städtisches Klinikum Solingen, Solingen, Germany
c Institut für Arterioskleroseforschung an der Westfälischen Wilhelms-Universität Münster, Münster, Germany
d Klinik und Poliklinik für Kinderheilkunde, Westfälische Wilhelms-Universität Münster, Münster, Germany
e Herz- und Gefäßklinik Bad Neustadt/Saale, Bad Neustadt Saale, Germany
f Klinikum Meiningen, Meiningen, Germany

revised April 24, 2001; accepted April 25, 2001

Abstract

Aims Recent studies have reported an association between the platelet glycoprotein (GP) Ia C807T polymorphism and myocardial infarction, whereas other studies have reported contradictory results concerning the platelet GPIIIa PlA1/A2 polymorphism. In most of these studies the patients were older than 45 years. Thus we decided to examine both genotypes in 287 men who had their first myocardial infarction before age 45, and a group of 138 healthy controls.

Methods and Results The frequency of T807 allele carriers was similar among myocardial infarction patients and among controls (54·6% vs 62·3%; odds ratio (OR) 0·73; 95% confidence interval (CI), 0·47–1·12). The frequency of PlA2 carriers was higher in cases than in controls (26·5% vs 15·2%; OR 1·65; CI, 1·09–2·54). After performing a logistic regression analysis, taking into account other cardiovascular risk factors, this difference did not remain significant. The combination of the risk alleles of both genotypes had no major effect on the myocardial infarction risk.

Conclusions The GPIIIa PlA2 allele is not independently associated with the risk of premature myocardial infarction. The T807 allele of the GPIa gene alone or in combination with the PlA2 allele had no major effect on premature myocardial infarction risk.

Key Words: Myocardial infarction, platelets, GPIa, C807T polymorphism, GPIIIa, PIA polymorphism, risk factor

f1 Correspondence: Ralf Junker, MD, Institut für Klinische Chemie und Laboratoriumsmedizin, Westfälische Wilhelms-Universität Münster, Albert Schweitzer-Strasse 33, 48129 Münster, Germany.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CLIN APPL THROMB HEMOSTHome page
C. Sucker, M. Schmitz, G. R. Hetzel, B. Grabensee, B. Maruhn-Debowski, L. Ostojic, R. E. Scharf, and R. B. Zotz
Are Prothrombotic Variants of Platelet Glycoprotein Receptor Polymorphisms Involved in the Pathogenesis of Thrombotic Microangiopathies?
Clinical and Applied Thrombosis/Hemostasis, August 1, 2009; 15(4): 402 - 407.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
G. Hsiao, J. J. Lee, K. H. Lin, C. H. Shen, T. H. Fong, D. S. Chou, and J. R. Sheu
Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: In vitro and in vivo studies
Cardiovasc Res, September 1, 2007; 75(4): 782 - 792.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
C. Antoniades, D. Tousoulis, C. Vasiliadou, E. Stefanadi, K. Marinou, and C. Stefanadis
Genetic Polymorphisms of Platelet Glycoprotein Ia and the Risk for Premature Myocardial Infarction: Effects on the Release of sCD40L During the Acute Phase of Premature Myocardial Infarction
J. Am. Coll. Cardiol., May 16, 2006; 47(10): 1959 - 1966.
[Abstract] [Full Text] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
V. Wiwanitkit
PIA1/A2 Polymorphism of the Platelet Glycoprotein Receptor IIb/IIIIa and Its Correlation With Myocardial Infarction: An Appraisal
Clinical and Applied Thrombosis/Hemostasis, January 1, 2006; 12(1): 93 - 95.
[Abstract] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
J. Mikkelsson, M. Perola, and P. J. Karhunen
Genetics of Platelet Glycoprotein Receptors: Risk of Thrombotic Events and Pharmacogenetic Implications
Clinical and Applied Thrombosis/Hemostasis, April 1, 2005; 11(2): 113 - 125.
[Abstract] [PDF]

Home page
 BloodHome page
L. He, L. K. Pappan, D. G. Grenache, Z. Li, D. M. Tollefsen, S. A. Santoro, and M. M. Zutter
The contributions of the {alpha}2{beta}1 integrin to vascular thrombosis in vivo
Blood, November 15, 2003; 102(10): 3652 - 3657.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. G. Grenache, T. Coleman, C. F. Semenkovich, S. A. Santoro, and M. M. Zutter
{alpha}2{beta}1 Integrin and Development of Atherosclerosis in a Mouse Model: Assessment of Risk
Arterioscler Thromb Vasc Biol, November 1, 2003; 23(11): 2104 - 2109.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
B. Swynghedauw
Susceptibility-conferring polymorphic genotypes in cardiovascular multifactorial syndromes
Eur. Heart J., February 2, 2002; 23(4): 271 - 273.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.