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European Heart Journal 2003 24(15):1383-1384; doi:10.1016/S0195-668X(03)00281-1
Copyright © 2003 by the European Society of Cardiology.
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Editorial

Early invasive therapy of non ST-elevation acute coronary syndromes — combined with upstream antiplatelet therapy: yes — but how early?

Kari Niemelä* and Saila Vikman

Division of Cardiology, Department of Internal Medicine, Tampere University Hospital, PL 2000, FI-33521, Tampere, Finland

* Correspondence to: Kari Niemelä. Tel. +358-3-2474312; fax +358-3-2474157
E-mail address: kari.niemela@pshp.fi

Received 19 May 2003; revised 19 May 2003; accepted 21 May 2003

The first 10% of the full text of this article appears below.

See doi:10.1016/S1095-668X(03)00259-8for the article to which this editorial refers

The increasing number of patients with non ST-elevation acute coronary syndromes (ACS) is placing an enormous economic burden on health care in Western countries. Recently updated European and American guidelines have clarified the recommendations for how these patients should be treated.1,2The well-conducted FRISC II trial strongly suggested the superiority of early invasive strategy compared to a more watchful ‘wait-and-see’ conservative strategy.3These observations were further confirmed by the TACTICS–TIMI 18 trial,4where early invasive strategy with an adjunctive upstream glycoprotein (GP) 2b/3a inhibitor from 4 to 48h (median 22h) before the intervention appeared to result in . . . [Full Text of this Article]


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