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European Heart Journal 2003 24(22):1993-1994; doi:10.1016/j.ehj.2003.08.005
Copyright © 2003 by the European Society of Cardiology.
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Editorial

Statin therapy: new therapy for cardiac microvascular dysfunction

Robert S Rosenson*

Preventive Cardiology Center, Division of Cardiology, Departments of Medicine and Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

* Corresponding author. Tel.: +1-312-695-0013; fax: +1-312-695-0047
E-mail address: r-rosenson@northwestern.edu

Received 12 August 2003; accepted 21 August 2003

The first 10% of the full text of this article appears below.

See doi:10.1016/S1095-668X(03)00478-0for the article to which this editorial refers

Cardiac syndrome-X is a clinical entity characterized by angina-like chest discomfort that is often prolonged in duration, normal coronary arteries as assessed by arteriography, non-inducible coronary vasospasm with ergonovine provocation and ST segment depression on treadmill exercise testing. The pathogenesis of cardiac syndrome-X has been ascribed to myocardial ischaemia that may be caused by microvascular dysfunction and increased sensitivity to intracardiac pain. Support for impaired myocardial perfusion in the aetiology of chest pain was provided in a case-control study of 20 patients with established syndrome-X and 10 matched controls that underwent cardiac magnetic resonance imaging at rest and after adenosine infusion.1In syndrome-X patients, adenosine infusion reduced the subendocardial to subepicardial myocardial perfusion index and provoked chest pain in 19 . . . [Full Text of this Article]


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