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European Heart Journal 2003 24(4):297-298; doi:10.1016/S0195-668X(02)00753-4
Copyright © 2003 by the European Society of Cardiology.
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Editorial

Pulmonary arterial hypertension and the vasoconstrictive factor: is there still a role for vasodilator testing?

J.Simon R Gibbsa,b,*, John Whartona,b and Martin R Wilkinsa,b

a National Heart & Lung Institute and Section on Clinical Pharmacology, Imperial College London, London, UK
b Hammersmith Hospital, Du Cane Road, London W12 0HS, UK

Received October 8, 2002; accepted October 9, 2002 * Corresponding author. Department of Cardiology, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK. Tel.: +44-208-383-2330; fax: +44-208-383-2331
s.gibbs@ic.ac.uk

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See doi:10.1016/S1095-668X(02)00302-0for the article to which this editorial refers.

Recent years have witnessed a transformation in the treatments available for patients with pulmonary arterial hypertension with the development of new therapies that offer significant therapeutic benefit. While the inspiration behind them may have been based on tipping a perceived imbalance in vasoconstrictor–vasodilator activity towardsvasodilation, it is emerging that the main action of these new treatments is to prevent (and possibly reverse) pulmonary vascular remodelling. Should this insight change our protocol for investigating and working up . . . [Full Text of this Article]


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