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European Heart Journal 2003 24(5):377-380; doi:10.1016/S0195-668X(02)00752-2
Copyright © 2003 by the European Society of Cardiology.
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Hotline Editorial

Oral contraceptives and the risk of myocardial infarction

B.C Tanis*

Department of Haematology and Clinical Epidemiology, Leiden University Medical Center, Building 1, C9-P P.O. Box 9600, Leiden 2300, The Netherlands

* Tel.: +31-71-5264037; fax: +31-71-5266994
E-mail address: b.tanis@planet.nl

The first 10% of the full text of this article appears below.

The risk of arterial thrombosis in relation to oral contraceptives (RATIO) study investigated the association between currently used oral contraceptives and myocardial infarction, according to the type of progestagen, oestrogen dose, and the presence of prothrombotic mutations (factor V Leiden and prothrombin G20210A mutation). In this nationwide population-based case-control study 248 women with a first myocardial infarction between 1990 and 1995 were compared with 925 control women without a cardiovascular event. Control women were identified through random digit dialing and they were stratified for age, calendar year of myocardial infarction and the area of residence. Information on oral contraceptive use and cardiovascular risk factors was acquired by standardized questionnaires. Current use was defined as use in the month before the indexdate. Current oral contraceptive use (all types) was associated with a 2-fold increased risk (95% confidence interval (CI) 1.5–2.8) of myocardial infarction when compared with non-users. . . . [Full Text of this Article]

1. Background

2. Oral contraceptives as a risk factor for myocardial infarction

3. Clinical implications


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