Skip Navigation

European Heart Journal 2003 24(7):639-648; doi:10.1016/S0195-668X(02)00741-8
Copyright © 2003 by the European Society of Cardiology.
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Natali, A.
Right arrow Articles by Ferrannini, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Natali, A.
Right arrow Articles by Ferrannini, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Regular Articles

Erythrocyte sedimentation rate, coronary atherosclerosis, and cardiac mortality

Andrea Natalia,*, Antonio L'Abbateb and Ele Ferranninia

a Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa 56100, Italy
b Coronary Division of the C.N.R. Institute of Clinical Physiology, University of Pisa, Via Roma 67,Pisa 56100, Italy

* Correspondence author. Tel.: +39-050-99-2814; fax: +39-050-55-3235
E-mail address: anatali{at}ifc.cnr.it

Received 26 August 2002; revised 8 October 2002; accepted 9 October 2002

Aims To test whether the erythrocyte sedimentation rate (ESR) is related to the extension of coronary atherosclerosis (ATS) and predicts cardiac mortality.

Methods and results Hospital-based, retrospective observational (median follow up: 92 months) cohort study. In 1726 consecutive patients undergoing angiography, coronary ATS and subsequent mortality were related to ESR and to classical risk factors. Patients undergoing angiography for reasons different from ischemic heart disease (IHD), served as control. ESR was progressively higher in the presence of 1, 2, or 3-vessel disease. Age-and sex-adjusted ESR was positively related to ATS both in univariate analysis (, ) and in a multivariate model including principal risk factors (partial , ). Similar associations were observed in the control group. Over the follow-up period, 170 patients died of a cardiac cause. When male and female patients in their upper ESR quartile (>18 and >23mm/h, respectively) were compared with the remainder of the cohort, their age-and gender-adjusted odds ratio for cardiac mortality was 1.72 (, ). This result held true, in men, also when using a full set of risk factors in a Cox model.

Conclusions ESR is an independent correlate of coronary ATS and, in male patients with probable IHD, a predictor of cardiac death.

Key Words: Erythrocyte sedimentation rate • Inflammation • Coronary atherosclerosis • Cardiac mortality • Risk factors • Ischemic heart disease


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Diabetes CareHome page
S. R. de Rooij, G. Nijpels, P. M. Nilsson, J. J. Nolan, R. Gabriel, E. Bobbioni-Harsch, G. Mingrone, J. M. Dekker, and for the Relationship Between Insulin Sensitivity a
Low-Grade Chronic Inflammation in the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) Population: Associations with insulin resistance and cardiometabolic risk profile
Diabetes Care, July 1, 2009; 32(7): 1295 - 1301.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.