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European Heart Journal 2004 25(13):1091-1092; doi:10.1016/j.ehj.2004.05.001
Copyright © 2004 by the European Society of Cardiology.
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Editorial

Muscarinic subtype-2 receptor autoantibodies: actors or bystanders in human atrial fibrillation?

Dobromir Dobrev*, Torsten Christ and Ursula Ravens

Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany

* Correspondence to: Dobromir Dobrev, Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscher Str 74, 01307 Dresden, Germany. Tel.: +49-351-458-6279; fax: +49-351-458-6315
E-mail address: dobrev@rcs.urz.tu-dresden.de

The first 10% of the full text of this article appears below.

This editorial refers to "Autoantibodies against M2 muscarinic acetylcholine receptors: new upstream targets in atrial fibrillation in patients with dilated cardiomyopathy"1 by A. Baba et al. on page 1108

Atrial fibrillation (AF) is currently the most common cardiac arrhythmia in the clinical setting. It is associated with a shortening of action potential duration (APD) and effective refractory period (ERP) and a loss of physiological rate-dependent adaptation that can be explained by concomitant alterations in ion channel activity.1 These electrophysiological changes (electrical remodelling) promote the induction and the persistence of the arrhythmia. In addition, changes . . . [Full Text of this Article]


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Related articles in EHJ:

Autoantibodies against M2-muscarinic acetylcholine receptors: new upstream targets in atrial fibrillation in patients with dilated cardiomyopathy
Akiyasu Baba, Tsutomu Yoshikawa, Yukiko Fukuda, Takashi Sugiyama, Megumi Shimada, Makoto Akaishi, Kanji Tsuchimoto, Satoshi Ogawa, and Michael Fu
EHJ 2004 25: 1108-1115. [Abstract] [FREE Full Text]