Copyright © 2004 by the European Society of Cardiology.
Clinical research
Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study
a The Framingham Study, Boston University School of Medicine, 73 Mt Wayte Ave Suite 2, Framingham, MA, USA
b Department of Preventive Medicine, Boston University School of Medicine, Boston, MA, USA
c Cardiology Section, Boston University School of Medicine, Boston, MA, USA
d Myocardial Biology Unit, Boston University School of Medicine, Boston, MA, USA
e NHLBI, USA
Received October 15, 2003;
revised May 4, 2004;
accepted May 26, 2004
* Corresponding author. Tel.: +1-508-935-3450; fax: +1-508-626-1262
vasan{at}bu.edu
See page 1475 for the editorial comment on this article1
Aims Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a key regulator of extracellular matrix degradation. We examined relations of plasma total TIMP-1 to cardiovascular risk factors and echocardiographic left ventricular (LV) structure and function in a community-based sample.
Methods and results We studied 1069 Framingham Heart Study participants (mean age 56 years, 58% women) free of heart failure and previous myocardial infarction. Plasma TIMP-1 was higher in men compared with women, and increased with age, body mass index and total/HDL–cholesterol ratio, but decreased with alcohol intake. Plasma TIMP-1 was also directly related to smoking, diabetes and use of anti-hypertensive treatment. Adjusting for age, sex and height, plasma TIMP-1 was positively associated with LV mass, wall thickness, relative wall thickness, end-systolic diameter, and left atrial diameter and the risk of having increased LV end-diastolic diameter or increased wall thickness, and negatively correlated with fractional shortening. Additional adjustment for clinical covariates attenuated the relations of plasma TIMP-1 to most echocardiographic measures.
Conclusions In our cross-sectional investigation, plasma total TIMP-1 was related to major cardiovascular risk factors and to indices of LV hypertrophy and systolic dysfunction. This raises the possibility that cardiovascular risk factors may influence cardiovascular remodelling via extracellular matrix degradation, which may be reflected in plasma TIMP-1 levels.
Key Words: Heart failure • Left ventricular hypertrophy • Metalloproteinases • Remodelling • Echocardiography
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in EHJ:
- TIMPs, MMPs and cardiovascular disease
- Franz H. Messerli
EHJ 2004 25: 1475-1476.[Extract] [FREE Full Text]
This article has been cited by other articles:
|
|
 |
|
  R. S. Vasan, S. Demissie, M. Kimura, L. A. Cupples, C. White, J. P. Gardner, X. Cao, D. Levy, E. J. Benjamin, and A. Aviv Association of Leukocyte Telomere Length With Echocardiographic Left Ventricular Mass: The Framingham Heart Study Circulation, September 29, 2009; 120(13): 1195 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dhingra, M. J. Pencina, P. Schrader, T. J. Wang, D. Levy, K. Pencina, D. A. Siwik, W. S. Colucci, E. J. Benjamin, and R. S. Vasan Relations of Matrix Remodeling Biomarkers to Blood Pressure Progression and Incidence of Hypertension in the Community Circulation, March 3, 2009; 119(8): 1101 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kelly, S. Q. Khan, M. Thompson, G. Cockerill, L. L. Ng, N. Samani, and I. B. Squire Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction Eur. Heart J., September 1, 2008; 29(17): 2116 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. West, P. J. Nestel, A. C. Kirby, R. Schnabel, D. Sullivan, R. J. Simes, C. Pollicino, E. Lubos, T. F. Munzel, H. D. White, et al. The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study Eur. Heart J., April 1, 2008; 29(7): 923 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Casaclang-Verzosa, B. J. Gersh, and T. S.M. Tsang Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation. J. Am. Coll. Cardiol., January 1, 2008; 51(1): 1 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Jensen, B. Sloth, I. Krog-Mikkelsen, A. Flint, A. Raben, T. Tholstrup, N. Brunner, and A. Astrup A low-glycemic-index diet reduces plasma plasminogen activator inhibitor-1 activity, but not tissue inhibitor of proteinases-1 or plasminogen activator inhibitor-1 protein, in overweight women Am. J. Clinical Nutrition, January 1, 2008; 87(1): 97 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Spinale Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function Physiol Rev, October 1, 2007; 87(4): 1285 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Huang, K.-L. Chien, W.-J. Chen, F.-C. Sung, H.-C. Hsu, T.-C. Su, and Y.-T. Lee Impact of heart failure and left ventricular function on long-term survival -- Report of a community-based cohort study in Taiwan Eur J Heart Fail, June 1, 2007; 9(6-7): 587 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Webb, D. D. Bonnema, S. H. Ahmed, A. H. Leonardi, C. D. McClure, L. L. Clark, R. E. Stroud, W. C. Corn, L. Finklea, M. R. Zile, et al. Specific Temporal Profile of Matrix Metalloproteinase Release Occurs in Patients After Myocardial Infarction: Relation to Left Ventricular Remodeling Circulation, September 5, 2006; 114(10): 1020 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Alla, A. Kearney-Schwartz, A. Radauceanu, S. D. Dores, B. Dousset, and F. Zannad Early changes in serum markers of cardiac extra-cellular matrix turnover in patients with uncomplicated hypertension and type II diabetes Eur J Heart Fail, March 1, 2006; 8(2): 147 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lubos, R. Schnabel, H. J. Rupprecht, C. Bickel, C. M. Messow, S. Prigge, F. Cambien, L. Tiret, T. Munzel, and S. Blankenberg Prognostic value of tissue inhibitor of metalloproteinase-1 for cardiovascular death among patients with cardiovascular disease: results from the AtheroGene study Eur. Heart J., January 2, 2006; 27(2): 150 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Szmigielski, M. Raczkowska, G. Styczynski, P. Pruszczyk, and Z. Gaciong Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham Heart Study Eur. Heart J., February 2, 2005; 26(4): 418 - 418. [Full Text] [PDF]
|
|
|
|
|
|
J. Sundstrom and R. S. Vasan Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham Heart Study: reply Eur. Heart J., February 2, 2005; 26(4): 418 - 419. [Full Text] [PDF]
|
|
|
|
|
|
F. H. Messerli TIMPs, MMPs and cardiovascular disease Eur. Heart J., September 1, 2004; 25(17): 1475 - 1476. [Full Text] [PDF]
|
|