Skip Navigation

European Heart Journal 2004 25(17):1534-1541; doi:10.1016/j.ehj.2004.06.015
Copyright © 2004 by the European Society of Cardiology.
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (23)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Covolo, L.
Right arrow Articles by Dei Cas, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Covolo, L.
Right arrow Articles by Dei Cas, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Clinical research

Role of ß1- and ß2-adrenoceptor polymorphisms in heart failure: a case-control study

Loredana Covoloa, Umberto Gelattia, Marco Metrab,*, Savina Nodarib, Antonio Piccichèa, Natalia Pezzalib, Claudia Zania, Adriana Albertia, Francesco Donatoa, Giuseppe Nardia and Livio Dei Casb

a Cattedra di Igiene, Università   di Brescia, Italy
b Cattedra di Cardiologia, Università  di Brescia, c/o Spedali Civili, P.zza Spedali Civili 1, 25123 Brescia, Italy

Received November 4, 2003; revised May 30, 2004; accepted June 10, 2004 * Corresponding author. Tel.: +39-30-3995572; fax: +39-30-3700359 (E-mail: metramarco{at}libero.it).

BACKGROUND: We hypothesised that the polymorphisms of the genes encoding for ß1- and the ß2-adrenoceptors may have a role in the pathogenesis of heart failure (HF). We therefore compared the polymorphisms of the ß1-adrenoceptor gene (Arg389Gly), the ß2-adrenoceptor gene (Arg16Gly, Gln27Glu) and their combinations in patients with HF and normal subjects living in the same area.

METHODS AND RESULTS: A total of 256 cases with HF (left ventricular ejection fraction ⩽40%) and 230 normal subjects were enrolled. The ß1- and ß2-adrenoceptor gene polymorphisms were assessed by PCR, followed by restriction enzyme digestion. No differences were observed in the distribution of any of the three genotypes studied in patients with HF and normal subjects. An analysis of the genotype combinations showed a non-significant increase in the risk of HF associated with the Arg389Gly16Gln27 (odds ratio=1.4; 95%CI 0.5–3.6) and Arg389Gly16 Glu27 (odds ratio=1.2; 95%CI, 0.5–2.8) homozygous allele combinations.

CONCLUSION: None of the three most common polymorphisms of ß-adrenoreceptors are associated with an increased risk of HF.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur J Heart FailHome page
A. Muthumala, F. Drenos, P. M. Elliott, and S. E. Humphries
Role of {beta} adrenergic receptor polymorphisms in heart failure: Systematic review and meta-analysis
Eur J Heart Fail, January 1, 2008; 10(1): 3 - 13.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
G. Kitsios and E. Zintzaras
Genetic Variation associated with Ischemic Heart Failure: A HuGE Review and Meta-Analysis
Am. J. Epidemiol., September 15, 2007; 166(6): 619 - 633.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
N. Sotoodehnia, D. S. Siscovick, M. Vatta, B. M. Psaty, R. P. Tracy, J. A. Towbin, R. N. Lemaitre, T. D. Rea, J. P. Durda, J. M. Chang, et al.
{beta}2-Adrenergic Receptor Genetic Variants and Risk of Sudden Cardiac Death
Circulation, April 18, 2006; 113(15): 1842 - 1848.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
M. Metra, C. Zani, L. Covolo, S. Nodari, N. Pezzali, U. Gelatti, F. Donato, G. Nardi, and L. D. Cas
Role of {beta}1- and {alpha}2c-adrenergic receptor polymorphisms and their combination in heart failure: A case-control study
Eur J Heart Fail, March 1, 2006; 8(2): 131 - 135.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.