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European Heart Journal 2004 25(19):1675-1678; doi:10.1016/j.ehj.2004.07.031
Copyright © 2004 by the European Society of Cardiology.
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Current opinion

Isoprostanes, emerging biomarkers and potential mediators in cardiovascular diseases

Jean-Luc Cracowskia,* and Olivier Ormezzanob

a Laboratoire de Pharmacologie, Faculté de Médecine de Grenoble, HP2 EA 3745, France
b Department of Cardiology, Grenoble University Hospital, France

* Correspondence to: Laboratoire de Pharmacologie, Faculté de Médecine de Grenoble, HP2 EA 3745, 38700 La Tronche, France. Tel.: +33 4 76 76 92 60; fax: +33 4 76 76 92 62 (E-mail: jean-luc.cracowski@ujf-grenoble.fr).

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Arachidonic acid is an essential unsaturated fatty acid and is the most abundant in cell membranes. Its metabolism leads to the formation of the well known prostaglandins and thromboxanes, which are implicated in the modulation of vascular tone and growth and play an important role on the blood-vessel interface. The discovery of their pharmacological activity led to the development of some potent drugs such as the prostacyclin analogues, while thromboxane A2-receptor antagonists are currently under development. While research on arachidonic acid metabolites focused for decades on the enzymatic pathway, Morrow and Roberts 1 described in 1990 another pathway of arachidonic acid metabolism, i.e., a free radical pathway, leading to a large series of compounds termed isoprostanes.

A first level of complexity is that, unlike the enzymatic formation . . . [Full Text of this Article]


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