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European Heart Journal Advance Access originally published online on November 23, 2004
European Heart Journal 2005 26(1):18-26; doi:10.1093/eurheartj/ehi002
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Clinical research

Mortality rates in patients with ST-elevation vs. non-ST-elevation acute myocardial infarction: observations from an unselected cohort

Christian Juhl Terkelsen1,*, Jens Flensted Lassen1, Bjarne Linde Nørgaard1, Jens Christian Gerdes1,2, Tage Jensen2, Liv Bjørn-Hansen Gøtzsche2, Torsten Toftegaard Nielsen1 and Henning Rud Andersen1

1Department of Cardiology, Skejby University Hospital, DK-8200 Aarhus N, Denmark
2Department of Internal Medicine, Randers County Hospital, DK-8900 Randers, Denmark

Received 3 June 2004; revised 10 October 2004; accepted 14 October 2004 online publish-ahead-of-print 23 November 2004 * Corresponding author. Tel: +45 89496234; fax: +45 89496009. E-mail address: christian_juhl_terkelsen{at}hotmail.com

See page 1 for the editorial comment on this article (doi:10.1093/eurheartj/ehi062)

Aims Acute myocardial infarction (AMI) is categorized, according to the presenting electrocardiogram, into non-ST-elevation myocardial infarction (non-STEMI), ST-elevation myocardial infarction (STEMI), or bundle branch block myocardial infarction (BBBMI). Data on the prognostic significance of these categories mainly originate from voluntary based registries or large-scale clinical trials and may be hampered by selection and information bias. The aim of this historical cohort study was to evaluate the prognostic significance of different categories of AMI in an unselected cohort.

Methods and results From 1 November 1999 to 31 October 2001, patient records were reviewed from all admissions to hospitals serving a study region with 139 000 inhabitants. An Endpoint Committee determined whether patients fulfilled the European Society of Cardiology criteria of AMI. A total of 654 patients with AMI were identified. The proportion having non-STEMI, STEMI, and BBBMI was 54, 39 and 6%, and the associated 1 year mortality was 31, 21, and 55%, respectively (log rank 54, P<0.001). The more favourable outcome observed in patients with STEMI remained significant according to multivariable analysis (P=0.044).

Conclusion In an unselected cohort of patients admitted with AMI, the mortality was considerably higher than expected from voluntary-based registries and large-scale clinical trials. The most favourable outcome is observed in patients with STEMI.

Key Words: Myocardial infarction • Prognosis • Cohort study • Selection bias • Information bias


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