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European Heart Journal Advance Access originally published online on April 8, 2005
European Heart Journal 2005 26(11):1049-1051; doi:10.1093/eurheartj/ehi243
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Drug-eluting stents for chronic total occlusions make sense, but it is too early to close the discussion

Erik Jørgensen* and Henning Kelbæk

2014 Cardiac Catheterisation Laboratory, The Heart Centre, Rigshospitalet, 2100 Copenhagen, Denmark

* Corresponding author. Tel: +45 3545 3693; fax: +45 3545 2705. E-mail address: erik.joergensen@rh.hosp.dk

This editorial refers to ‘Immediate and mid-term outcomes of sirolimus-eluting stent implantation for chronic total occlusions’{dagger} by L. Ge et al., on page 1056

The first 10% of the full text of this article appears below.

Stent implantation compared with balloon angioplasty alone has proved not only to increase procedural safety but also to reduce elastic recoil and vascular remodelling and to improve immediate and long-term clinical and angiographic outcomes in patients with coronary artery disease.1,2 The use of intravascular ultrasound-guided high pressure stent implantation has reduced the frequency of stent thrombosis.3 However, stents induce a neo-intimal hyperplasia during the initial 9 months after implantation, and this hyperplasia results in a binary restenosis rate of 10–40%. In addition, patient subsets with small vessels, long lesions, multi-vessel disease, diabetics, renal failure, or complex lesions morphology, such as bifurcations or total occlusions have an even higher incidence of in-stent restenosis.

Most large pivotal studies of stent . . . [Full Text of this Article]


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Related articles in EHJ:

Immediate and mid-term outcomes of sirolimus-eluting stent implantation for chronic total occlusions
Lei Ge, Ioannis Iakovou, John Cosgrave, Alaide Chieffo, Matteo Montorfano, Iassen Michev, Flavio Airoldi, Mauro Carlino, Gloria Melzi, Giuseppe M. Sangiorgi, Nicola Corvaja, and Antonio Colombo
EHJ 2005 26: 1056-1062. [Abstract] [FREE Full Text]