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European Heart Journal Advance Access originally published online on April 19, 2005
European Heart Journal 2005 26(15):1482-1487; doi:10.1093/eurheartj/ehi261
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Accuracy of MSCT coronary angiography with 64-slice technology: first experience

Sebastian Leschka1, Hatem Alkadhi1, André Plass2, Lotus Desbiolles1, Jürg Grünenfelder2, Borut Marincek1 and Simon Wildermuth1,*

1Department of Medical Radiology, Institute of Diagnostic Radiology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland
2Clinic for Cardiovascular Surgery, University Hospital Zurich, Switzerland

Received 17 December 2004; revised 7 March 2005; accepted 15 March 2005; online publish-ahead-of-print 19 April 2005.

* Corresponding author. Tel: +41 1 255 3662; fax: +41 1 255 4443. E-mail address: simon.wildermuth{at}usz.ch

See page 1451 for the editorial comment on this article (doi:10.1093/eurheartj/ehi322)

Aims The aim of our study was to investigate the accuracy of 64-slice computed tomography (CT) for assessing haemodynamically significant stenoses of coronary arteries.

Methods and results CT angiography was performed in 67 patients (50 male, 17 female; mean age 60.1±10.5 years) with suspected coronary artery disease and compared with invasive coronary angiography. All vessels ≥1.5 mm were considered for the assessment of significant coronary artery stenosis (diameter reduction >50%). Forty-seven patients were identified as having significant coronary stenoses on invasive angiography with 18% (176/1005) affected segments. None of the coronary segments needed to be excluded from analysis. CT correctly identified all 20 patients having no significant stenosis on invasive angiography. Overall sensitivity for classifying stenoses was 94%, specificity was 97%, positive predictive value was 87%, and negative predictive value was 99%.

Conclusion Sixty-four-slice CT provides a high diagnostic accuracy in assessing coronary artery stenoses.

Key Words: Computed tomography • Conventional coronary angiography • Coronary artery disease


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Eur. Heart J., February 2, 2008; 29(4): 531 - 556.
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J. Horiguchi, M. Kiguchi, C. Fujioka, Y. Shen, R. Arie, K. Sunasaka, and K. Ito
Radiation Dose, Image Quality, Stenosis Measurement, and CT Densitometry Using ECG-Triggered Coronary 64-MDCT Angiography: A Phantom Study
Am. J. Roentgenol., February 1, 2008; 190(2): 315 - 320.
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F. Pugliese, N. R. Mollet, M. G. M. Hunink, F. Cademartiri, K. Nieman, R. T. van Domburg, W. B. Meijboom, C. Van Mieghem, A. C. Weustink, M. L. Dijkshoorn, et al.
Diagnostic Performance of Coronary CT Angiography by Using Different Generations of Multisection Scanners: Single-Center Experience
Radiology, February 1, 2008; 246(2): 384 - 393.
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L. Husmann, I. Valenta, O. Gaemperli, O. Adda, V. Treyer, C. A. Wyss, P. Veit-Haibach, F. Tatsugami, G. K. von Schulthess, and P. A. Kaufmann
Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gating
Eur. Heart J., January 2, 2008; 29(2): 191 - 197.
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F. J. Rybicki, T. Sheth, and F. Y. Chen
Cardiac Surgical Imaging
Card. Surg. Adult, January 1, 2008; 3(2008): 179 - 198.
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G Pundziute, J D Schuijf, J W Jukema, J M van Werkhoven, E Boersma, A de Roos, E E van der Wall, and J J Bax
Gender influence on the diagnostic accuracy of 64-slice multislice computed tomography coronary angiography for detection of obstructive coronary artery disease
Heart, January 1, 2008; 94(1): 48 - 52.
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J. Hausleiter, T. Meyer, M. Hadamitzky, M. Zankl, P. Gerein, K. Dorrler, A. Kastrati, S. Martinoff, and A. Schomig
Non-invasive coronary computed tomographic angiography for patients with suspected coronary artery disease: the Coronary Angiography by Computed Tomography with the Use of a Submillimeter resolution (CACTUS) trial
Eur. Heart J., December 2, 2007; 28(24): 3034 - 3041.
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J. Abdulla, S. Z. Abildstrom, O. Gotzsche, E. Christensen, L. Kober, and C. Torp-Pedersen
64-multislice detector computed tomography coronary angiography as potential alternative to conventional coronary angiography: a systematic review and meta-analysis
Eur. Heart J., December 2, 2007; 28(24): 3042 - 3050.
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A. R. Simon, H. Baraki, J. Weidemann, W. Harringer, M. Galanski, and A. Haverich
High-resolution 64-slice helical-computer-assisted-tomographical-angiography as a diagnostic tool before CABG surgery: the dawn of a new era?
Eur. J. Cardiothorac. Surg., December 1, 2007; 32(6): 896 - 901.
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C. S. White and D. Kuo
Chest Pain in the Emergency Department: Role of Multidetector CT
Radiology, December 1, 2007; 245(3): 672 - 681.
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F. Saremi, A. Abolhoda, O. Ashikyan, J. C. Milliken, J. Narula, S. V. Gurudevan, K. Kaushal, and A. Raney
Arterial Supply to Sinuatrial and Atrioventricular Nodes: Imaging with Multidetector CT
Radiology, December 1, 2007; 246(1): 99 - 107.
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M. Hamon, R. Morello, J. W. Riddell, and M. Hamon
Coronary Arteries: Diagnostic Performance of 16- versus 64-Section Spiral CT Compared with Invasive Coronary Angiography Meta-Analysis
Radiology, December 1, 2007; 245(3): 720 - 731.
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H. Brodoefel, U. Kramer, A. Reimann, C. Burgstahler, S. Schroeder, A. Kopp, and M. Heuschmid
Dual-Source CT with Improved Temporal Resolution in Assessment of Left Ventricular Function: A Pilot Study
Am. J. Roentgenol., November 1, 2007; 189(5): 1064 - 1070.
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W. B Meijboom, N. R Mollet, C. A Van Mieghem, A. C Weustink, F. Pugliese, N. van Pelt, F. Cademartiri, E. Vourvouri, P. de Jaegere, G. P Krestin, et al.
64-Slice CT coronary angiography in patients with non-ST elevation acute coronary syndrome
Heart, November 1, 2007; 93(11): 1386 - 1392.
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L. Husmann, S. Leschka, L. Desbiolles, T. Schepis, O. Gaemperli, B. Seifert, P. Cattin, T. Frauenfelder, T. G. Flohr, B. Marincek, et al.
Coronary Artery Motion and Cardiac Phases: Dependency on Heart Rate Implications for CT Image Reconstruction
Radiology, November 1, 2007; 245(2): 567 - 576.
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W. B. Meijboom, C. A.G. van Mieghem, N. R. Mollet, F. Pugliese, A. C. Weustink, N. van Pelt, F. Cademartiri, K. Nieman, E. Boersma, P. de Jaegere, et al.
64-Slice Computed Tomography Coronary Angiography in Patients With High, Intermediate, or Low Pretest Probability of Significant Coronary Artery Disease
J. Am. Coll. Cardiol., October 9, 2007; 50(15): 1469 - 1475.
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M. Dewey, H.-P. Dubel, T. Schink, G. Baumann, and B. Hamm
Head-to-head comparison of multislice computed tomography and exercise electrocardiography for diagnosis of coronary artery disease
Eur. Heart J., October 2, 2007; 28(20): 2485 - 2490.
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A. W. Leber, T. Johnson, A. Becker, F. von Ziegler, J. Tittus, K. Nikolaou, M. Reiser, G. Steinbeck, C. R. Becker, and A. Knez
Diagnostic accuracy of dual-source multi-slice CT-coronary angiography in patients with an intermediate pretest likelihood for coronary artery disease
Eur. Heart J., October 1, 2007; 28(19): 2354 - 2360.
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G. T. Wilson, P. Gopalakrishnan, and T. Tak
Noninvasive Cardiac Imaging with Computed Tomography
Clin. Med. Res., October 1, 2007; 5(3): 165 - 171.
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H. Alkadhi, L. Desbiolles, L. Husmann, A. Plass, S. Leschka, H. Scheffel, R. Vachenauer, T. Schepis, O. Gaemperli, T. G. Flohr, et al.
Aortic Regurgitation: Assessment with 64-Section CT
Radiology, October 1, 2007; 245(1): 111 - 121.
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D. Matt, H. Scheffel, S. Leschka, T. G. Flohr, B. Marincek, P. A. Kaufmann, and H. Alkadhi
Dual-Source CT Coronary Angiography: Image Quality, Mean Heart Rate, and Heart Rate Variability
Am. J. Roentgenol., September 1, 2007; 189(3): 567 - 573.
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L. J. M. Kroft, A. de Roos, and J. Geleijns
Artifacts in ECG-Synchronized MDCT Coronary Angiography
Am. J. Roentgenol., September 1, 2007; 189(3): 581 - 591.
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A.-C. Pouleur, J.-B. le Polain de Waroux, A. Pasquet, J.-L. J. Vanoverschelde, and B. L. Gerber
Aortic Valve Area Assessment: Multidetector CT Compared with Cine MR Imaging and Transthoracic and Transesophageal Echocardiography
Radiology, September 1, 2007; 244(3): 745 - 754.
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A. C. Weustink, W. B. Meijboom, N. R. Mollet, M. Otsuka, F. Pugliese, C. van Mieghem, R. Malago, N. van Pelt, M. L. Dijkshoorn, F. Cademartiri, et al.
Reliable High-Speed Coronary Computed Tomography in Symptomatic Patients
J. Am. Coll. Cardiol., August 21, 2007; 50(8): 786 - 794.
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