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European Heart Journal Advance Access originally published online on March 22, 2005
European Heart Journal 2005 26(15):1499-1505; doi:10.1093/eurheartj/ehi179
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Risk factors for out-of-hospital cardiac arrest: the Reykjavik Study

Gestur Thorgeirsson1,*, Gudmundur Thorgeirsson1,2, Helgi Sigvaldason2 and Jacqueline Witteman3

1Department of Cardiology, Landspítali University Hospital, Hringbraut, 101 Reykjavik, Iceland
2The Icelandic Heart Association, Reykjavik, Iceland
3The Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands

Received 7 May 2004; revised 18 January 2005; accepted 27 January 2005; online publish-ahead-of-print 22 March 2005.

* Corresponding author. Tel: +354 543 1000; fax: +354 543 6467. E-mail address: gesturth{at}landspitali.is

Aims To examine risk factors for out-of-hospital cardiac arrest in the Reykjavik Study, a long-term, prospective, population-based cohort study that started in 1967.

Methods and results From 1987 to 1996, 137 men and 44 women out of the 8006 men and 9435 women in the study sustained out-of-hospital cardiac arrest due to cardiac causes. Determinants included coronary artery disease (CAD), its classical risk factors, and age, body mass index (BMI), heart rate, cardiomegaly, and erythrocyte sedimentation rate. Electrocardiograms (ECGs) were examined for various abnormalities. Significance was determined by Cox regression analysis. In multivariable analysis, the risk in men was significantly associated with age, diastolic blood pressure, cholesterol, current smoking, and previous diagnosis of myocardial infarction (MI). In women, the risk was associated with diastolic blood pressure, elevated levels of cholesterol and triglycerides, and increased voltage on ECG. Increased BMI was inversely related to women's risk of out-of-hospital cardiac arrest.

Conclusion In this prospective, population-based cohort study previous MI and the classical risk factors for CAD significantly increased the risk of out-of-hospital cardiac arrest, the endpoint of this study. Increased voltage on ECG additionally increased women's risk.

Key Words: Out-of-hospital cardiac arrest • Myocardial infarction • Smoking • Cholesterol • Hypertension


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