European Heart Journal Advance Access originally published online on June 2, 2005
European Heart Journal 2005 26(16):1640-1646; doi:10.1093/eurheartj/ehi340
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Adiponectin, risk of coronary heart disease and correlations with cardiovascular risk markers
1Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
2Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria
3Department of Internal Medicine II—Cardiology, University of Ulm Medical Center, Robert-Koch Str. 8, 89081 Ulm, Germany
Received 22 December 2004; revised 20 April 2005; accepted 28 April 2005; online publish-ahead-of-print 2 June 2005.
* Corresponding author. Tel: +49 731 500 24465; fax: +49 731 500 33872. E-mail address: wolfgang.koenig{at}medizin.uni-ulm.de
See page 1579 for the editorial comment on this article (doi:10.1093/eurheartj/ehi374)
Aims We investigated the association of serum adiponectin concentrations with the risk of coronary heart disease (CHD) after careful adjustment for other established risk factors. In addition, we investigated the association between adiponectin levels and established sociodemographic and laboratory risk markers for CHD.
Methods and results Three hundred and twelve patients aged 40–68 with angiographically confirmed stable CHD and 476 age- and gender-matched controls were included in this case–control study. Adiponectin serum concentrations (adiponectin, R&D Systems, Wiesbaden, Germany), markers of inflammation and haemostasis, and an extensive lipid profile were determined. Adiponectin serum concentrations were lower in CHD patients when compared with age- and gender-matched controls, both in men (median 4.95 vs. 5.58 µmol/L, P=0.004) and in women (median 9.64 vs. 11.60 µmol/L, P=0.018). Adiponectin was strongly correlated with lipoproteins and apolipoproteins, in particular HDL-cholesterol (HDL-C), and to a lesser degree with markers of inflammation such as C-reactive protein, IL-6, or markers of coagulation or fibrinolysis. When compared with subjects with adiponectin serum concentrations in the lower quintile, the OR for CHD was 0.52 (95% CI 0.28–0.95) in the upper one after adjustment for covariates (P<0.007 for trend). After additional adjustment for HDL-C the association was strongly reduced, reflecting the close association between adiponectin and HDL-C.
Conclusion Adiponectin serum concentrations may have an important role in the development of CHD. The protective effect of high serum concentration may partly be mediated by effects on the metabolism of lipoproteins, especially on the metabolism of HDL.
Key Words: Adiponectin • Coronary heart disease • Inflammation • Lipids • Case–control study
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