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European Heart Journal Advance Access originally published online on December 9, 2004
European Heart Journal 2005 26(2):173-179; doi:10.1093/eurheartj/ehi040
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European Heart Journal vol. 26 no. 2 © The European Society of Cardiology 2004; all rights reserved.

Left atrial myopathy in cardiac amyloidosis: implications of novel echocardiographic techniques

Karen M. Modesto1, Angela Dispenzieri2, Sanderson A. Cauduro1, Martha Lacy2, Bijoy K. Khandheria1, Patricia A. Pellikka1, Marek Belohlavek1, James B. Seward1, Robert Kyle2, A. Jamil Tajik1, Morie Gertz2 and Theodore P. Abraham1,*

1Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
2Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN, USA

Received 16 February 2004; revised 21 September 2004; accepted 1 October 2004; online publish-ahead-of-print 9 December 2004.

* Corresponding author: Johns Hopkins University, 600 North Wolfe Street, Carnegie 568, Baltimore, MD 21287, USA. Tel: +1 410 955 2412; fax: +1 410 955 0223. E-mail address: tabraha3{at}jhmi.edu

Aims To assess left atrial (LA) function and determine the prevalence of LA dysfunction in AL amyloidosis (AL) using conventional and strain echocardiography.

Methods and results LA ejection fraction, LA filling fraction, LA ejection force, peak LA systolic strain rate (LAsSR), and LA systolic strain (LA {varepsilon}) were determined in 95 AL patients (70 with and 25 without echocardiographic evidence of cardiac involvement, abbreviated CAL and NCAL, respectively), 30 age-matched controls (CON), and 20 patients with diastolic dysfunction and LA dilatation (DD). Peak LAsSR >2 standard deviations below mean CON value was used as the cut-off for normal LA function. LA ejection fraction was lower in CAL when compared with CON (40.4±13.6 vs. 67.0±6%, P=0.01). Left atrial septal strain rate and strain were lower in CAL (0.8±0.5 s–1 and 5.5±4%, respectively) compared with CON (1.8±0.8 s–1 and 14±4%, respectively, P=<0.0001), NCAL (1.6±0.8 s–1 and 13±7%, respectively, P<0.0001) and DD (1.3±0.4 s–1 and 10±2%, respectively, P<0.0001). Based on peak LA systolic strain rate criteria, the cut-off values for normal LA function were –1.1 s–1 and –1.05 s–1 for lateral and septal walls. Using these criteria, LA dysfunction was identified in 32% (lateral LA criteria) and 60% (septal LA criteria) of CAL patients. Lateral and septal LAsSR were lower in CAL patients with vs. those without symptoms of heart failure. Inter- and intra-observer agreement was high for LA strain echocardiography.

Conclusion LA function assessment using strain echocardiography is feasible with low intra- and inter-observer variability. LA dysfunction is observed in AL patients without other echocardiographic features of cardiac involvement and may contribute to cardiac symptoms in CAL.

Key Words: Amyloidosis • Strain • Atrial function • Echocardiography


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