Skip Navigation


European Heart Journal Advance Access originally published online on June 24, 2005
European Heart Journal 2005 26(20):2142-2147; doi:10.1093/eurheartj/ehi376
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
26/20/2142    most recent
ehi376v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Jouven, X.
Right arrow Articles by Siscovick, D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jouven, X.
Right arrow Articles by Siscovick, D. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Diabetes, glucose level, and risk of sudden cardiac death

Xavier Jouven1,2,*, Rozenn N. Lemaître3, Thomas D. Rea3, Nona Sotoodehnia3, Jean-Philippe Empana2 and David S. Siscovick3

1Service de Cardiologie, Université Paris-5, Faculté René Descartes, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
2Equipe AVENIR et Unité INSERM 258, Hôpital Paul Brousse, Villejuif, France
3University of Washington, Cardiovascular Research Unit, Metropolitan Park, East Tower, Seattle, WA 98101, USA

Received 25 August 2004; revised 20 April 2005; accepted 19 May 2005; online publish-ahead-of-print 24 June 2005.

* Corresponding author. Fax: +33 1 56 09 22 64. E-mail address: xavier.jouven{at}egp.ap-hop-paris.fr

Aims The prevalence of diabetes mellitus in industrialized countries is rapidly increasing, and diabetes is suspected to carry a particular high risk for sudden cardiac death (SCD).

Methods and results We conducted a population-based case–control study at Group Health Cooperative. Cases (n=2040) experienced out-of-hospital cardiac arrest due to heart disease between 1980 and 1994. Controls (n=3800) were a stratified random sample of enrollees. Diabetes status was classified into four exclusive groups: (i) no diabetes, (ii) borderline, (iii) diabetes without microvascular disease (retinopathy or proteinuria), and (iv) diabetes with microvascular disease. When compared with no diabetes, we observed progressively higher risk of SCD associated with borderline diabetes [Odds ratio (OR)=1.24 (0.98–1.57)], diabetes without microvascular disease [OR=1.73 (1.28–2.34)], and diabetes with microvascular disease [OR=2.66 (1.84–3.85)], after adjustment for potential confounders (P-value for trend <0.001). Higher glucose levels were also associated with the risk of SCD both in the absence and in the presence of microvascular disease. However, subjects with microvascular complications but with glucose level <7.7 mmol/L were not at significant increased risk of SCD.

Conclusion These results emphasize the role of diabetes as a strong risk factor for SCD and outline the importance of glucose level at every stage of diabetes severity.

Key Words: Sudden death • Cardiac arrest • Diabetes • Glycaemia


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
K Majamaa-Voltti, J Turkka, M-L Kortelainen, H Huikuri, and K Majamaa
Causes of death in pedigrees with the 3243A>G mutation in mitochondrial DNA
J. Neurol. Neurosurg. Psychiatry, February 1, 2008; 79(2): 209 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
Authors/Task Force Members, L. Ryden, E. Standl, M. Bartnik, G. V. d. Berghe, J. Betteridge, M.-J. de Boer, F. Cosentino, B. Jonsson, M. Laakso, et al.
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
Eur. Heart J. Suppl., June 1, 2007; 9(suppl_C): C3 - C74.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
Authors/Task Force Members, L. Ryden, E. Standl, M. Bartnik, G. Van den Berghe, J. Betteridge, M.-J. de Boer, F. Cosentino, B. Jonsson, M. Laakso, et al.
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
Eur. Heart J., January 1, 2007; 28(1): 88 - 136.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
V. Salomaa
Sweet and sour coronary heart disease: results from the China Heart Survey
Eur. Heart J., November 1, 2006; 27(21): 2491 - 2492.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
E. C. Stecker, C. Vickers, J. Waltz, C. Socoteanu, B. T. John, R. Mariani, J. H. McAnulty, K. Gunson, J. Jui, and S. S. Chugh
Population-Based Analysis of Sudden Cardiac Death With and Without Left Ventricular Systolic Dysfunction: Two-Year Findings from the Oregon Sudden Unexpected Death Study
J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1161 - 1166.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.