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European Heart Journal Advance Access originally published online on March 9, 2005
European Heart Journal 2005 26(7):642-643; doi:10.1093/eurheartj/ehi201
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis

Decheng Yang* and Dexin Qiu

Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital-University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia, Canada V6Z IY6

* Corresponding author. Tel: +604 682 2344 ext. 62872; fax: +604 806 9274. E-mail address: dyang@mrl.ubc.ca

This editorial refers to ‘Elevated expression of PDGF-C in coxsackievirus B3-induced chronic myocarditis’{dagger} by K. Grün et al., on page 728

The first 10% of the full text of this article appears below.

Coxsackievirus B3 (CVB3) is the most common causative agent of myocarditis.1 Acute myocarditis caused by CVB3 infection either recovers completely without any functional and morphological defects or progresses to chronic myocarditis, which is characterized by chronic inflammation and interstitial hyperplasia that may be related to progressive intrinsic dysfunction, degeneration, and loss of cardiomyocyte viability.2 In later stages of this disease, CVB3 persists in the myocardium and results in chronic activation of fibroblasts and progressive fibrosis of the myocardium, reflected by the accumulation of connective tissue and extracellular matrix, which is characteristic of dilated cardiomyopathy (DCM).3,4 However, the molecular mechanisms by which acute myocarditis progresses to chronic myocarditis and DCM still . . . [Full Text of this Article]


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Related articles in EHJ:

Elevated expression of PDGF-C in coxsackievirus B3-induced chronic myocarditis
Katja Grün, Boyka Markova, Frank-D. Böhmer, Alexander Berndt, Hartwig Kosmehl, and Carola Leipner
EHJ 2005 26: 728-739. [Abstract] [Full Text]