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European Heart Journal Advance Access originally published online on March 16, 2006
European Heart Journal 2006 27(11):1338-1340; doi:10.1093/eurheartj/ehi793
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart

Jozef Bartunek1, Stephanie Dimmeler2, Helmut Drexler3, Francisco Fernández-Avilés4, Manuel Galinanes5, Stefan Janssens6, John Martin7,*, Anthony Mathur8, Phillipe Menasche9, Sylvia Priori10, Bodo Strauer11, Michal Tendera12, William Wijns13 and Andreas Zeiher14

1 Cardiovascular Center, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium
2 Molecular Cardiology, Department of Medicine III, J.W. Goethe University, Frankfurt, Germany
3 Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
4 Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico-Universitario, Valladolid, Spain
5 Cardiac Surgery Unit, Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
6 Department of Cardiology, University Hospital, Gasthuisberg, Leuven, Belgium
7 Centre for Cardiovascular Biology & Medicine, BHF Laboratories at University College London, 5, University Street, London WC1E 6JJ
8 Department of Cardiology, London Chest Hospital, Bonner Road, London, UK
9 Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, Department of Cardiovascular Surgery, Universite Paris-Descartes, Faculte de Medecine, INSERM U 633, France
10 Department of Cardiology, University of Pavia, Italy
11 Heinrich-Heine-Universitat Dusseldorf, Klinik fur Kardiologie, Pneumologie und Angiologie, Moorenstr. 5 40225 Dusseldorf, Germany
12 3rd Division of Cardiology, School of Medicine, Katowice Poland
13 Cardiovascular Centre Aalst, OLV Clinic, Aalst, Belgium
14 Molecular Cardiology, Department of Medicine III, J.W. Goethe University, Frankfurt, Germany

Received 16 January 2006; accepted 26 January 2006; online publish-ahead-of-print 16 March 2006.

* Corresponding author: Tel: +44 20 7679 6339; fax: +44 20 7679 6379. E-mail address: john.martin{at}ucl.ac.uk

A task force has been established by the European Society of Cardiology to investigate the role of progenitor/stem cell therapy in the treatment of cardiovascular disease. This article is the consensus of this group, of what clinical studies are needed in this field, and the challenges to be addressed in the translation of progenitor/stem cell biology to repair of the heart.

Key Words: Adult progenitor cell • Stem cell • Cardiovascular • Autologous • Growth factors • Cardiac repair • Bone marrow progenitor cell • Skeletal myoblast


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