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European Heart Journal Advance Access originally published online on May 22, 2006
European Heart Journal 2006 27(15):1778-1784; doi:10.1093/eurheartj/ehl034
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Relation between baseline plaque burden and subsequent remodelling of atherosclerotic left main coronary arteries: a serial intravascular ultrasound study with long-term (≥12 months) follow-up

Marc Hartmann1, Clemens von Birgelen1,*, Gary S. Mintz2, Patrick M.J. Verhorst1 and Raimund Erbel3

1 Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, Haaksbergerstraat 55, 7513 ER Enschede, The Netherlands
2 Cardiovascular Research Foundation, New York, NY, USA
3 Department of Cardiology, Essen University, Essen, Germany

Received 2 March 2006; revised 27 March 2006; accepted 27 April 2006; online publish-ahead-of-print 22 May 2006.

* Corresponding author. Tel: +31 53 487 2490; fax: +31 53 487 2152. E-mail address: von.birgelen{at}12move.nl

See page 1761 for the editorial comment on this article (doi:10.1093/eurheartj/ehl129)

Aims Glagov's histopathological observation and non-serial intravascular ultrasound studies (IVUS) concluded that compensatory coronary remodelling diminishes as 40% atherosclerotic plaque burden is reached. We tested this hypothesis with serial IVUS.

Methods and results Serial IVUS examinations of 46 atherosclerotic non-stenotic left main stems (18±8 months apart) were analysed to assess the relation between baseline plaque burden (=plaque+media area/vessel area) vs. serial remodelling (=vessel area at baseline–at follow-up). There were 25 plaques with baseline plaque burden <40% (30.1±6.6%, group A) and 21 plaques with baseline plaque burden ≥40% (46.1±5.8%, group B). There was no relation between baseline plaque burden vs. subsequent changes in vessel area overall (r=0.07, P=0.7), for group A (r=0.03, P=0.6), and group B (r=0.01, P=0.8). The frequency of positive serial remodelling (vessel area increase) vs. negative or intermediate serial remodelling (no change or decrease) were similar in group A [17 (68%) vs. 8 (32%)] and group B lesions [18 (86%) vs. 3 (14%)] (P=0.2).

Conclusion IVUS demonstrates that serial coronary remodelling is not related to baseline plaque burden. Lesions with baseline plaque burden <40% may subsequently show a lack of compensation or frank arterial shrinkage, whereas lesions with baseline plaque burden >40% may continue to develop compensatory enlargement.

Key Words: Coronary artery disease • Intravascular ultrasound • Remodelling


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