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European Heart Journal Advance Access originally published online on August 21, 2006
European Heart Journal 2006 27(18):2165-2169; doi:10.1093/eurheartj/ehl192
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Expression of platelet collagen receptor glycoprotein VI is associated with acute coronary syndrome

Boris Bigalke1, Stephan Lindemann1,*, Raila Ehlers1, Peter Seizer1, Karin Daub1, Harald Langer1, Tanja Schonberger1, Elisabeth Kremmer2, Dorothea Siegel-Axel1, Andreas E. May1 and Meinrad Gawaz1,*

1 Medizinische Klinik III, Eberhard Karls-Universität Tübingen, Otfried-Müller-Str. 10, D-72076 Tübingen, Germany
2 Institute for Molecular Immunology, GSF-National Research Center for Environment and Health, Munich, Germany

Received 4 March 2006; revised 23 June 2006; accepted 27 July 2006; online publish-ahead-of-print 21 August 2006.

* Corresponding author. Tel: +49 7071 29 83688; fax: +49 7071 29 5749. E-mail address: stephan.lindemann{at}med.uni-tuebingen.de or meinrad.gawaz{at}med.uni-tuebingen.de

Aims Platelet collagen receptor glycoprotein VI (GPVI) is critical for the formation of arterial thrombosis. In this observational study, we examined the platelet surface expression of GPVI in patients with symptomatic coronary artery disease (CAD).

Methods and results We evaluated a consecutive cohort of 367 patients with symptomatic CAD, who underwent coronary angiography. The surface expression of platelet activation markers (GPVI, CD62P, and CD42b) was determined by flow cytometry. Patients with acute coronary syndrome (ACS) showed a significantly enhanced GPVI expression on admission when compared with patients with stable angina pectoris (SAP) (ACS: 21.4±9.7; SAP: 18.6±7.1 mean fluorescence intensity±SD; P=0.004). The expression of GPVI correlated with CD62P (r=0.702; P=0.001). Logistic regression analysis demonstrated that on admission, elevated platelet GPVI expression was associated with ACS, independent of markers of myocardial necrosis such as troponin and creatine kinase.

Conclusion Platelet GPVI surface expression is elevated in patients with ACS and is associated with imminent acute coronary events. The determination of the platelet-specific thrombotic marker GPVI may help to identify patients at risk before myocardial ischaemia is evident.

Key Words: Platelets • Glycoprotein VI • Collagen • Acute coronary syndrome


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