European Heart Journal Advance Access originally published online on August 1, 2006
European Heart Journal 2006 27(18):2177-2183; doi:10.1093/eurheartj/ehl160
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sex-based short- and long-term survival in patients following complicated myocardial infarction
1 University of Bergen, Stavanger University Hospital, Stavanger, Norway
2 Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
3 Merck Research Laboratories, West Point, PA, USA
Received 29 August 2005; revised 3 July 2006; accepted 6 July 2006; online publish-ahead-of-print 1 August 2006.
* Corresponding author. Tel: +47 51518000; fax: +47 51519905. E-mail address: bove{at}sir.no
Aims Mortality in women following an acute myocardial infarction (AMI) is higher than in men, in that women are older and have more co-morbidity at the time of AMI. We evaluated short- and long-term sex-related differences in management and prognosis among high-risk patients following AMI.
Methods and results A total of 1575 women and 3902 men with AMI and heart failure, left ventricular dysfunction, or anterior Q waves, were recruited for participation in the OPTIMAAL trial and followed for 2.7±0.9 years in seven European countries. Symptomatic heart failure was more common in women when compared with men. Women were older, with more hypertension and diabetes mellitus. Fewer women were treated with thrombolytics (P<0.001 in all cases). Women had a 1.37-fold higher risks of death (P<0.001) during follow-up, but no differences were observed after adjusting for age. However, in-hospital mortality was significantly higher in women (4.89 vs. 2.54%; P<0.001) and a 1.57-fold higher risk of in-hospital death (P=0.006) persisted after adjusting for age and co-morbidities.
Conclusion Among high-risk patients with AMI, age-adjusted long-term survival was similar between sexes. However, adjusted in-hospital mortality was significantly higher in women. Higher short-term risk may warrant more rapid and appropriate management of women with AMI.
Key Words: Female gender • Myocardial infarction • Heart failure • Prognosis • Early mortality
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. J. Shaw, R. Bugiardini, and C. N. B. Merz Women and ischemic heart disease: evolving knowledge. J. Am. Coll. Cardiol., October 20, 2009; 54(17): 1561 - 1575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Jonassaint, S. H. Boyle, R. B. Williams, D. B. Mark, I. C. Siegler, and J. C. Barefoot Facets of Openness Predict Mortality in Patients With Cardiac Disease Psychosom Med, May 1, 2007; 69(4): 319 - 322. [Abstract] [Full Text] [PDF]
|
|