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European Heart Journal Advance Access originally published online on September 11, 2006
European Heart Journal 2006 27(19):2272-2274; doi:10.1093/eurheartj/ehl234
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Determinants of microvascular flow

Sanjiv Kaul* and Ananda R. Jayaweera

Division of Cardiovascular Medicine, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA

* Corresponding author. Tel: +1 503 494 8750; fax: +1 503 494 8550. E-mail address: kauls@ohsu.edu

This editorial refers to ‘A novel, hydrodynamic approach to the treatment of coronary artery disease’{dagger} by J.J. Pacella et al., on page 2362

The first 150 words of the full text of this article appear below.

The Hagen–Poiseuille's equation states that flow (Q) in a tube can be calculated as follows: ({Delta}P{pi}r4)/(8l{eta}), where l and r are the length and radius of the tube, respectively, {eta} the viscosity of the fluid flowing through the tube, and {Delta}P the pressure gradient across the tube. By analogy with Ohms law, the total resistance R to flow is given by {Delta}P/Q or Q={Delta}P/R. By combining the two equations, we get [(8l)/({pi}r4)]{eta}. In large vessels viscosity plays a minor role. For most clinical cardiologists, whose view of coronary artery flow is limited to that in the epicardial coronary arteries, the term r4 is all important. Once in a while they also argue about the term l, especially if they see segments with long stenosis or several stenoses in series on coronary angiography. This equation is . . . [Full Text of this Article]


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Related articles in EHJ:

A novel hydrodynamic approach to the treatment of coronary artery disease
John J. Pacella, Marina V. Kameneva, Melissa Csikari, Erxiong Lu, and Flordeliza S. Villanueva
EHJ 2006 27: 2362-2369. [Abstract] [Full Text]