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European Heart Journal Advance Access originally published online on October 6, 2006
European Heart Journal 2006 27(21):2489-2490; doi:10.1093/eurheartj/ehl299
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Toll the bell for another genetic association?

Bernard Keavney

Institute of Human Genetics, Newcastle University, UK

Corresponding author. E-mail address: b.d.keavney@ncl.ac.uk

This editorial refers to ‘Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population’{dagger} by W. Koch et al., on page 2524

The first 150 words of the full text of this article appear below.

The reliable identification of common genetic differences between individuals, which could account for a proportion of a person's susceptibility to atherosclerosis, has so far been difficult to achieve. The field has been characterized by non-replicable associations, often initially claimed in studies far too small to provide robust evidence, and subsequently contradicted by much larger studies.1 Indeed, it could be argued that after huge expenditure of time and effort by many groups, only the association between the {varepsilon}4 allele of the apolipoprotein E {varepsilon}2/{varepsilon}3/{varepsilon}4 polymorphism and coronary heart disease risk has ‘cast-iron’ evidence in its favour both from large studies involving several thousands of disease cases, and from meta-analyses. Recently, however, there are more encouraging signs, as several groups present results obtained in studies large enough to confirm or refute the presence of the rather small-sized associations (relative risks of disease amounting to 15–20% or so), which are likely . . . [Full Text of this Article]


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Related articles in EHJ:

Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population
Werner Koch, Petra Hoppmann, Arne Pfeufer, Albert Schömig, and Adnan Kastrati
EHJ 2006 27: 2524-2529. [Abstract] [Full Text]